Double-blind randomised placebo-controlled trial of bolus-dose vitamin D<sub>3</sub>supplementation in adults with asthma (ViDiAs)

Martineau, Adrian R.; MacLaughlin, Beverley; Hooper, Richard; Barnes, Neil; Jolliffe, David A.; Greiller, Claire; Kilpin, Kate; McLaughlin, David; Fletcher, G. T.; Mein, Charles A.; Hoti, Mimoza; Walton, Robert; Grigg, Jonathan; Timms, Philip; Rajakulasingam, Raj K; Bhowmik, Angshu; Rowe, Marion; Venton, Timothy R; Choudhury, Aklak; Simcock, David E; Sadique, Zia; Monteiro, William; Corrigan, Christopher; Hawrylowicz, Catherine M.; Griffiths, Christopher J.

doi:10.1136/thoraxjnl-2014-206449

Cited by 111 publications

(142 citation statements)

References 27 publications

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“…79,80,82 In addition, vitamin D significantly reduced the risk of patients having at least 1 emergency visit or hospitalization for an exacerbation (OR, 0.39; 95% CI, 0.19-0.78). 77,79,80,82,84,87 These effects are mainly attributable to studies performed in adults. Therefore, generalization of these results to children should be done with caution.…”

Section: 7881mentioning

confidence: 99%

“…Vitamin D supplementation significantly reduced the rate of asthma exacerbations treated with systemic corticosteroids (odds ratio [OR], 0.63; 95% CI, 0.45-0.88) 79,80,82,87 and tended to increase the time to first exacerbation (P = 0.052). 79,80,82 In addition, vitamin D significantly reduced the risk of patients having at least 1 emergency visit or hospitalization for an exacerbation (OR, 0.39; 95% CI, 0.19-0.78).…”

Section: 7881mentioning

confidence: 99%

“…77, 79,80,82,84,87 These effects are mainly attributable to studies performed in adults. Therefore, generalization of these results to children should be done with caution.…”

Section: 7881mentioning

confidence: 99%

“…The rate of asthma exacerbations requiring the use of corticosteroids was significantly reduced by vitamin D supplementation (adjusted incidence rate ratio, 0.74; 95% CI, 0.56-0.97; P = 0.03). 79,80,[84][85][86][87]90,91 Several trials also investigated whether vitamin D supplementation during pregnancy could decrease asthma in the offspring.…”

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confidence: 99%

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Vitamin D supplementation in respiratory diseases - evidence from RCT

Mathyssen¹,

Gayan‐Ramirez²,

Bouillon³

et al. 2017

Polish Archives of Internal Medicine

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Pulmonary diseases are one of the most important causes of morbidity and mortality. Although vitamin D is best known for its role in calcium, phosphorus, and bone homeostasis, it has gained attention in the recent years because of a wide range of extraskeletal effects, including its immunomodulatory and antibacterial potential. Vitamin D deficiency is highly prevalent in chronic pulmonary diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, tuberculosis, and asthma, and several clinical studies have been conducted investigating the effect of vitamin D supplementation on disease outcomes. In this review, we searched for positive evidence on vitamin D supplementation from randomized controlled trials and elaborated on the optimal serum vitamin D levels and dosing regimens for an effective intervention. While vitamin D supplementation seems to be beneficial as an add -on treatment for adult patients with asthma and a potent intervention to reduce exacerbations in patients with COPD, there is little evidence for its therapeutic use in cystic fibrosis, pneumonia, and tuberculosis. the debate on the appropriate levels of 25(OH)D is still ongoing, most studies define the levels of less than 20 ng/ml (50 nmol/l) as deficient because they are associated with chronic diseases. 5 This is also the threshold used in most governmental guidelines for vitamin D. 16 The levels below 10 ng/ml (25 nmol/l) are considered as severe deficiency because they are associated with an increased risk of rickets or osteomalacia. It is also assumed that patients with these levels exhibit a true risk for infections and chronic diseases. 17 Other research groups reported that the serum 25(OH)D concentrations of 30 ng/ml (75 nmol/l) or even higher, as found in native populations living around the equator, are needed for optimal health. 5,10 Importance of vitamin D in pulmonary diseases Vitamin D deficiency is associated with multiple diseases such as cancer, hypertension, and autoimmune diseases, but also with several lung diseases. 5 A recent meta -analysis demonstrated that vitamin D levels are significantly lower in patients with tuberculosis (TB) compared with controls (apart from the African population). 18 About 70% to 90% of patients with TB have 25(OH)D levels below 20 ng/ml. 19,20 Janssens et al 6 demonstrated that patients with COPD had significantly lower 25(OH)D levels compared with healthy smokers and that vitamin D deficiency correlated with disease severity. While 31% of the healthy smokers were vitamin D deficient, this percentage increased gradually to 60% in stage 3 of COPD according to the Global Initiative for Obstructive Lung Disease (GOLD) to even 77% in the most severe stage of the disease.Vitamin D deficiency is also highly prevalent in CF. Up to 75% of adults and 95% of pediatric patients with CF are vitamin D deficient, [21][22][23] despite routine oral supplementation. 24 In patients with CF, vitamin D deficiency seems to be associated with a decreased pulmonary function in adult...

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Section: 7881mentioning

confidence: 99%

Section: 7881mentioning

confidence: 99%

“…77, 79,80,82,84,87 These effects are mainly attributable to studies performed in adults. Therefore, generalization of these results to children should be done with caution.…”

Section: 7881mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D supplementation in respiratory diseases - evidence from RCT

Mathyssen¹,

Gayan‐Ramirez²,

Bouillon³

et al. 2017

Polish Archives of Internal Medicine

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show abstract

“…The most recent Cochrane systematic review metaanalysis found two RCTs that studied the efficacy of vitamin D supplementation in the treatment of adults with mild-tomoderate asthma [15]. Vitamin D supplementation with oral vitamin D3, 100,000 IU bolus once, then 4000 IU/day for 28 weeks in VIDA study [16] and bimonthly 6 mL Vigantol oil containing 120,000 IU vitamin D3 for 12 months (total of six doses) in ViDiAs study [17] did not reduce asthma exacerbations. None of these powerful high-quality RCTs support the usefulness of vitamin D supplementation in the treatment of asthma in order to reduce the number of exacerbations or improve the health-related quality of life of patients.…”

Section: Vitamin Dmentioning

confidence: 99%

Is there sufficient evidence to support the use of vitamin supplements in the asthmatic patient?

Rezaei

Mahmoudi

et al. 2017

Expert Review of Respiratory Medicine

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Vitamin D for the management of asthma

Martineau

Cates

Urashima

et al. 2016

Cochrane Database of Systematic Reviews

153

141

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Meta-analysis of a modest number of trials in people with predominantly mild to moderate asthma suggests that vitamin D is likely to reduce both the risk of severe asthma exacerbation and healthcare use. It is as yet unclear whether these effects are confined to people with lower baseline vitamin D status; further research, including individual patient data meta-analysis of existing datasets, is needed to clarify this issue. Children and people with frequent severe asthma exacerbations were under-represented; additional primary trials are needed to establish whether vitamin D can reduce the risk of severe asthma exacerbation in these groups.

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Double-blind randomised placebo-controlled trial of bolus-dose vitamin D₃supplementation in adults with asthma (ViDiAs)

Abstract: NCT00978315 (ClinicalTrials.gov).

Cited by 111 publications

References 27 publications

Vitamin D supplementation in respiratory diseases - evidence from RCT

Vitamin D supplementation in respiratory diseases - evidence from RCT

Is there sufficient evidence to support the use of vitamin supplements in the asthmatic patient?

Vitamin D for the management of asthma

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Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3supplementation in adults with asthma (ViDiAs)

Abstract: NCT00978315 (ClinicalTrials.gov).

Cited by 111 publications

References 27 publications

Vitamin D supplementation in respiratory diseases - evidence from RCT

Vitamin D supplementation in respiratory diseases - evidence from RCT

Is there sufficient evidence to support the use of vitamin supplements in the asthmatic patient?

Vitamin D for the management of asthma

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Product

Resources

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Double-blind randomised placebo-controlled trial of bolus-dose vitamin D₃supplementation in adults with asthma (ViDiAs)