Double‐blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy

Harati, Yadollah; Gooch, Clifton L.; Swenson, Michael; Edelman, Steven V.; Greene, David; Raskin, Philip; Donofrio, Pompeo; Cornblath, David; Sachdeo, Rǎjesh C.; Siu, Cynthia; Kamin, Marc

doi:10.1212/wnl.50.6.1842

Cited by 501 publications

(257 citation statements)

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“…It is an effective agent in the treatment of painful diabetic peripheral neuropathy compared with placebo as demonstrated by two large multicenter trials (129,130), and it appears to have long-term effects (131). Although tramadol has a lower potential for abuse compared with other opioids, given these safety concerns, it is not recommended for use as first-or second-line agent.…”

Section: Opioid and Atypical Opioid Analgesicsmentioning

confidence: 99%

Diabetic Neuropathy: A Position Statement by the American Diabetes Association

et al. 2016

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Section: Opioid and Atypical Opioid Analgesicsmentioning

confidence: 99%

Diabetic Neuropathy: A Position Statement by the American Diabetes Association

et al. 2016

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“…Because of codeine's genetic variability in its rate of metabolism, its use should be individualized. 51 Tramadol is a synthetic analog of codeine that has shown efcacy in neuropathic pain, 52 but has no anti-infammatory activity. It can increase the risk of seizures and serotonin syndrome because it is also a monoamine reuptake inhibitor.…”

Section: Reviewmentioning

confidence: 99%

Cancer-related pain management in clinical oncology

Cipta¹,

Pietras²,

Weiss³

et al. 2015

J Community Support Oncol

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Uncontrolled pain is one of the most feared and debilitating symptoms among cancer patients, and many suffer unnecessarily from suboptimal pain control. Cancer-related pain is often multidimensional and can affect all aspects of a patient's life. Hence, achieving adequate pain relief among cancer patients involves a proper assessment of psychosocial, spiritual, and physical pain issues, matched with an individualized treatment plan involving pharmacologic, nonpharmacologic, and procedural therapies when appropriate. Providing effective pain relief can help ease the overall burden of disease among oncology patients while helping them tolerate cancer-directed therapies and achieve the most optimal quality of life throughout all phases of the disease continuum. In this review, the authors will discuss the syndromes, assessment of, and treatment for cancer-related pain in the outpatient setting.

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“…A recent study in Greece found pregabalin to be more cost effective as compared to gabapentin [73]. A double blinded randomised trial study of tramadol has been proven to be successful in alleviating pain symptoms in diabetic neuropathy [74]. Aldose reductase inhibitors are being studied and have shown to be effective in inhibiting progression of peripheral neuropathy [75,76].…”

Section: Medical Treatmentmentioning

confidence: 99%

Diabetic Foot Ulcer – Diagnosis and Management

Pai¹

2013

Clin Res Foot Ankle

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Diabetes Mellitus is known to have many complications and one of the most distressing is diabetic foot ulcer which affects 15% of people with diabetes. It puts enormous financial burden on the patient and the health care services, even though it is preventable. Diabetic foot ulcer is characterized by a classical triad of neuropathy, ischemia, and infection. Each of these has a multifactorial aetiopathogenesis. These factors are compounded by mechanical stress created by foot deformities. The most commonly used classification systems are the Wagner-Ulcer Classification system and the University of Texas Wound Classification. These classifications help to predict the outcome of this condition. Prevention of this condition is paramount to prevent long term morbidity and sometimes mortality. This can be achieved by patient self-awareness and emphasis on regular foot examinations during follow-up. Care of the diabetic foot should be multidisciplinary. Debridement, dressings and offloading are the pillars of local management. Simultaneous glycemic and infection control is also essential. Amputations are usually the treatment of last resort but occasionally can be considered early to allow for faster mobilization and rehabilitation. Causative factors like peripheral vasculopathy and neuropathy must also be appropriately treated.

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Double‐blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy

Abstract: The results of this placebo-controlled trial showed that tramadol was effective and safe in treating the pain of diabetic neuropathy.

Cited by 501 publications

References 0 publications

Diabetic Neuropathy: A Position Statement by the American Diabetes Association

Diabetic Neuropathy: A Position Statement by the American Diabetes Association

Cancer-related pain management in clinical oncology

Diabetic Foot Ulcer – Diagnosis and Management

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