Double-blind study of erbium 169 injection (synoviorthesis) in rheumatoid digital joints.

Menkès, C J; Go, Alabi; Verrier, Pierre; Aignan, M; Delbarre, F

doi:10.1136/ard.36.3.254

Cited by 66 publications

(36 citation statements)

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“…Using the similar approach the RSO of small articulations of hand resulted in good therapeutic effect in 25/36 (69%) of patients at 6 months [14] and 128/154 (83%) of patients at 12 months [14,15] vs. 131/157 (83%) of patients at 6 months [12,16,17] and 135/186 (73%) of patients at 12 months [12,16,18] when RSO was performed using 169 Er-citrate alone, suggesting from pooled data of therapeutic effect at 12 months a significantly more frequent response to 169 Er-citrate+corticosteroid than to 169 Er-citrate alone (p = 0.019).…”

Section: Discussionmentioning

confidence: 99%

Radiosynoviorthesis of acromioclavicular joint using 169Er-citrate: prospective evaluation of efficacy

Vereb

Liepe²,

Fischer

et al. 2018

Nucl. Med. Rev.

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Section: Discussionmentioning

confidence: 99%

Radiosynoviorthesis of acromioclavicular joint using 169Er-citrate: prospective evaluation of efficacy

Vereb

Liepe²,

Fischer

et al. 2018

Nucl. Med. Rev.

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“…Si iniziò con le infiltrazioni di acido osmico, sostanza fortemente ossidante che agisce, per così dire, "bruciando" il panno sinoviale attraverso una reazione infiammatoria/necrotica (24). A questo tipo di trattamento, utilizzato prevalentemente nei paesi scandinavi, si sono poi affiancate altre opzioni a base di radiosotopi (sinoviortesi): 198 Au (25), 90 Yt (26), 169 Er (27), 186 Re (28), 32 P (29) e, più recentemente, 153 Sm legato a particelle d'idrossiapatite (30). Allo stato attuale, queste tecniche trovano la maggiore indicazione nell'artropatia associata all'emofilia (31), condizione morbosa in cui, già nel 1952, venne applicata una particolare terapia locale, che consisteva nell'inoculazione all'interno dell'articolazione di jaluronidasi (32).…”

Section: "Se Poi LI Funghi Degli Articoli Sono Da Gran Tempo Invecchiunclassified

On the main stages of the history of intra-articular therapy

Marson¹,

Pasero²,

Punzi³

et al. 2011

Reumatismo

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In quasi tutti i casi si tratterebbe, comunque, di manovre chirurgiche più che di vere e proprie punture articolari, che invece si renderanno pienamente applicabili solo nel XIX secolo con l'utilizzo sempre più diffuso di aghi cavi -peraltro già da tempo impiegati in procedure oftalmologiche (5) -e l'in-L' introduzione di sostanze medicamentose all'interno della cavità articolare, per la cura locale di molte reumoartropatie, è pratica relativamente recente, che ebbe il suo inizio, come vedremo, circa due secoli fa. È assai probabile che in tempi precedenti ci si limitasse ad evacuare l'articolazione tumefatta, con l'obiettivo di risolvere la discrasia umorale all'origine, secondo i principi della teoria ippocratica allora dominante, di qualsiasi malattia reumatica (gotta, artrite, reumatismo), senza aggiungere alcun principio terapeutico (1). Ciò si evince anche da quanto scritto da molti autori, a partire da Ippocrate (al capitolo 41 del trattato Sulle Malattie Interne si fa un chiaro riferimento alla puntura del ginocchio, in caso di versamento articolare) (2), passando Reumatismo, 2007; 59(3):262-268 SUMMARY In this review the main stages in the history of intra-articular therapy of the rheumatic diseases

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“…The British experience with regional irradiation for ankylosing spondylitis involved more than 14,000 patients treated with a minimum of 900 to 2,000 rads (3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

“…Local irradiation of pigmented villonodular synovitis and intraarticular injection of radionuclides have met with some success as alternatives to surgical synovectomy (3)(4)(5). We investigated how local irradiation of inflamed joints would compare to TLI in suppressing inflammatory arthiritis in an animal model.…”

Section: Total Lymphoid and Local Joint Irradiation In The Treatment mentioning

confidence: 99%

Total lymphoid and local joint irradiation in the treatment of adjuvant arthritis

Schurman

Hirshman

Strober

1981

Arthritis & Rheumatism

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Total lymphoid irradiation (TLI) with 3,400 rads delivered in 17 divided doses, 600 rads at local paw irradiation in 3 divided doses, or both TLI and local irradiation were used to treat Lewis rats with adjuvant arthritis. Either TLI alone or local paw irradiation modestly reduced the severity of arthritis compared to a control group (P < 0.05). TLI treated animals had more initial suppression of inflammation. Adjuvant rats treated with a combination of both TLI and local paw irradiation had a profound and long lasting reduction in inflammation and permanent arthritis (P < 0.001).Immunosuppression in one form or another is well known to be beneficial in the treatment of inflammatory polyarthropathies. The lymphocyte is integrally involved in the histopathology of all forms of inflammatory arthritis in humans and animals. Alkylating agents which are known to destroy lymphocytes and thoracic duct drainage which mechanically depletes lymphocytes are associated with a decrease in synovitis in patients with rheumatoid arthritis (1). We reasoned, therefore, that the technique of selective irradiation (TLI) used to treat Hodgkin's disease might prove to be a valuable treatment for inflammatory synovitis since this regimen produces long lasting immunosuppression and T lymphocytopenia (2). Local irradiation of pigmented villonodular synovitis and intraarticular injection of radionuclides have met with some success as alternatives to surgical synovectomy (3-5). We investigated how local irradiation of inflamed joints would compare to TLI in suppressing inflammatory arthiritis in an animal model. This report describes the results of TLI and local joint irradiation separately and in combination in adjuvant arthritis of rats. It was found that either TLI or local joint irradiation is therapeutic by itself, but the combination of both modalities is substantially more effective than either alone. MATERIALS AND METHODSExperimental scheme. Adult inbred Lewis rats weighing 350 to 500 gm were injected with 1.0 mg of Mycobacterium butyricum suspended in medium grade oil at a concentration of 10 mg/ml in the subcutaneous aspect of the left hind paw (LHP), in a procedure similar to that reported by Chang (6). On the seventeenth day after inoculation of the LHP, animals that developed arthritis in one or more of the remaining three paws and had a minimum arthritis rating score of three (see "Scoring of joints") were divided into four groups of approximately 4 animals each. Groups were chosen so that there was a similar distribution of arthritis, and the average score of each group was similar at the start. All treatment regimens started on the seventeenth day after adjuvant inoculation. One group served as controls and received no irradiation. A second group was given a total of 3,400 rads of TLI in divided doses of 200 rads/day on a 5-day-a-week basis over a period of 24 days. A third group of animals received both 3,400 rads of TLI and 600 rads to each of the four paws. The paws were irradiated with 200 rads/day for 3 days starting ...

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Double-blind study of erbium 169 injection (synoviorthesis) in rheumatoid digital joints.

Cited by 66 publications

References 1 publication

Radiosynoviorthesis of acromioclavicular joint using 169Er-citrate: prospective evaluation of efficacy

Radiosynoviorthesis of acromioclavicular joint using 169Er-citrate: prospective evaluation of efficacy

On the main stages of the history of intra-articular therapy

Total lymphoid and local joint irradiation in the treatment of adjuvant arthritis

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