Double-blind Trial of Linoleate Supplementation of the Diet in Multiple Sclerosis

Millar, J. H. D.; Zilkha, K. J.; Langman, M. J. S.; Wright, Helen Payling; Smith, Anthony D.; Belin, J; Thompson, R. H. S.

doi:10.1136/bmj.1.5856.765

Cited by 208 publications

(42 citation statements)

References 22 publications

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“…There has been a considerable interest in the possible role of unsaturated fatty acids in MS [34,35] leading to dietary intervention trials [36][37][38][39][40]. MS patients have sig nificantly lower proportions of linoleic and arachidonic acids in most of their erythrocyte phospholipids, with a compensatory increase in saturated fatty acids [41], Also, the concentration of linoleic acid is significantly lower in white blood cells and platelets in MS patients compared to controls [42], The blood level of various substances may be altered by the dietary intake.…”

Section: Discussionmentioning

confidence: 99%

Influence of Fatty Acid Content of Lysophosphatidyl Choline on Its Myelinotoxic Properties

Sedal

Jennings²,

Allt³

et al. 1992

Eur Neurol

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The efficacy of lysophosphatidyl choline (LPC) type I and type IV in producing demyelination was assessed in rat tibial and sural nerve. By light and electron microscopy, a greater myelinolytic activity was demonstrated with type I, and concomitantly electrophysiology showed a more severe conduction block. In teased nerve preparations and 1-um thin sections, demyelinated fibres were more frequent with LPC type I. At 1 h after injection, electron microscopy showed much more extensive myelin lysis in the form of fine vesicular debris. By 6 days, completely demyelinated fibres were much more common and associated Schwann cells contained either small quantities or no myelin debris. With type IV LPC, cytopathological changes were more extensive at 1 h. A minority of Schwann cells showed swollen hydropic cytoplasm and degradation of organelles. Axonal retraction from the myelin sheath occurred in occasional fibres, and in a few unmyelinated fibres axoplasm showed organelle depletion and increased granularity. By 6 days, Schwann cells still contained large quantities of gross myelin debris and had often retracted to expose extensive areas of axolemma. The findings suggest that the two types of LPC have different myelinolytic actions, which may be related to their different fatty acid content. A possible role for the two types of LPC in ‘bystander demyelination’ is considered.

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Section: Discussionmentioning

confidence: 99%

Influence of Fatty Acid Content of Lysophosphatidyl Choline on Its Myelinotoxic Properties

Sedal

Jennings²,

Allt³

et al. 1992

Eur Neurol

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“…In this way Millar et al carried out a double-blind study with LA and olive oil during 24 months. These authors reported an improvement in relapse severity and nonsignificant trends towards lower relapse rates but no difference in disability (Millar et al, 1973). Later, Paty et al did not find such effects in a similar trial with higher doses of oleic acid as a placebo (Paty et al, 1978).…”

Section: Clinical Trials In Human Patientsmentioning

confidence: 86%

Role of Fatty Acids in the Resolution of Autoimmune and Inflammatory Diseases

Puertollano¹,

Puertollano²,

Cienfuegos³

et al. 2011

Autoimmune Disorders - Current Concepts and Advances From Bedside to Mechanistic Insights

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“…Three randomized, blinded, placebo-controlled studies looked at supplementation with linoleic acid in people with MS. [10][11][12] The hypothesis was that a supplement of this polyunsaturated fatty acid, a component of myelin, might be able to alter the course of MS. The results of the studies were not conclusive: two showed a slight positive benefit, and the third showed no benefit.…”

Section: Background Diet Effect On Disease Risk Mortality and Exacementioning

confidence: 99%

Dietary Practices of People With Multiple Sclerosis

Goodman¹,

Gulick²

2008

International Journal of MS Care

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Good nutrition is important for good health, but little is known about current dietary practices of people with multiple sclerosis (MS). The purpose of this study was to determine current dietary practices and see how they relate to disability level, MS symptoms, dietary adequacy, and body mass index. The study sample consisted of 123 people with MS grouped according to mild-moderate or severe disability level. Participants completed a self-report mailed instrument regarding dietary practices and sources of nutrition information. Both disability groups reported food labels as their primary source of nutrition information; only 20% received information from a registered dietitian. The average intake for all food groups was less than recommended by Dietary Guidelines for Americans 2005 (US Departments of Health and Human Services and of Agriculture). Higher intake of whole-grain foods was shown to decrease elimination symptoms. Most respondents reported taking at least one supplement daily, especially multivitamins. Fatigue sometimes limited cooking by mild-moderately disabled and chewing by severely disabled patients. More than 50% of both groups were overweight or obese. The participants' current intake was suboptimal. Increased use of registered dietitians to educate people with MS, their care partners, and members of their health care team might result in improved dietary intake.

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Double-blind Trial of Linoleate Supplementation of the Diet in Multiple Sclerosis

Cited by 208 publications

References 22 publications

Influence of Fatty Acid Content of Lysophosphatidyl Choline on Its Myelinotoxic Properties

Influence of Fatty Acid Content of Lysophosphatidyl Choline on Its Myelinotoxic Properties

Role of Fatty Acids in the Resolution of Autoimmune and Inflammatory Diseases

Dietary Practices of People With Multiple Sclerosis

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