Double Centrifugation Versus Single Centrifugation of Bone Marrow Aspirate Concentrate in Sinus Floor Elevation: A Pilot Study

Ensayo clínico aleatorizado de elevación sinusal por abordaje lateral con hueso mineral bovino desproteinizado (hmbd) comparando dos tamaños de partículas: resultados clínicos e histológicos

“…(26) , Felice et al (27) , Oliveira et al (28) and Meloni et al (29) , we observed a 100% implant survival rate after one year.…”

“…En línea con lo reportado con autores precedentes como Di Stefano et al (26) Felice et al (27), Oliveira et al (28) y Meloni et al (29) se observó una tasa de supervivencia del 100% de los implantes instalados en el control de 1 año.…”

Maxillary sinus augmentation using chairside bone marrow aspirate concentrates for implant site development: a systematic review of histomorphometric studies

“…of patients (age range)No. of maxillary sinuses evaluatedDonor site for BMACClinical findings/implant survivalTiming of biopsyHistologic outcomesde Oliveira et al [12]SCG (BMAC obtained by single centrifugation and bone graft)DCG (BMAC obtained by double centrifugation and bone graft)Control (xenogenous bone graft alone)15 (mean age 55.4 years)21Posterior iliac crest- 68 implants were placed in the previously grafted sites, and 100% osseointegrated- Loading was applied after 6 months6 monthsVital mineralized tissue:- SCG 38.44%- DCG 34.63%- Control 27.30%- Not statistically differentNon-vital mineralized tissue:- SCG 13.70%- DCG 19.63%- Control 22.79%- Not statistically differentNon-mineralized tissue:- SCG 47.87%- DCG 45.73%- Control 49.90%- Not statistically differentPasquali et al [7]Test (BMAC and xenogenous bone graft)Control (xenogenous bone graft alone)8 (mean age 55.4 years)16Superior posterior iliac crest- At least two implants were placed in each previously grafted sites, and all implants osseointegrated- Loading was applied after a 6-month healing period6 monthsVital mineralized tissue:- Test 55.15%- Control 27.30%- Statistically significantNon-vital mineralized tissue:- Test 6.32%- Control 22.79%- Statistically significantNon-mineralized tissue:- Test 38.53%- Control 49.90%- Not statistically significantPayer et al [2]Test (porous bovine bone mineral together with tibial bone marrow aspirate)Control (bovine bone graft without any additive)6 (mean age 58.2 years)12Tibia- 44 implants were stable and osseointegrated at radiographic and Periotest evaluation3 months6 monthsNewly formed bone:3 months-Test 10.36%- Control 9.45%- Not statistically significant6 months- Test 14.12%- Control 10.41%- Not statistically significant3 and 6 months:- Not statistically significantBone-to-bone substitute contact:3 months-Test 16.40%- Control 15.06%- Not statistically significant6 months- Test 20.26%- Control 17.89%- Not statistically significant3 and 6 months:- Not statistically significantSauerbier et al [11]Open bone marrow-derived mononuclear cell isolation by synthetic poylsaccharide (FICOLL) method with bovine bone mineral (BBM)Closed bone marrow aspirate concentrate (BMAC) system with BBMFICOLL group 4 (mean age 59.5 years)BMAC group 7(mean age 55 years)FICOLL group 6BMAC group 12Superior posterior iliac spine- 50 implants were placed (17 FICOLL group and 33 BMAC group)- Implant survival was evaluated after 1 year- No implant out of 17 was lost in the FICOLL group, before prosthetic loading- 1 implant out of 33 failed in the BMAC group, before prosthetic loading- No implant was lost after loading- All 49 osseointegrated implants were loaded and in function…”

“…The reported ranges of vital mineralized tissue for the included studies for the BMAC groups were 34.63–55.15% compared to 27.30% for control groups [7, 12]. For vital mineralized bone, these studies reported variable statistical significance.…”

“…It is primarily used in orthopedics and requires good manufacturing practice laboratory techniques. Thus, the closed bone marrow aspirate concentrate (BMAC) system which can be done chairside has become an accepted means to harvest MNCs [12]. …”