We motivate the possibility of using notions and methods derived from quantum physics, and more specifically from the research field known as 'quantum cognition', to optimally model different situations in the field of medicine, its decision-making processes and ensuing practices, particularly in relation to chronic and rare diseases. This also as a way to devise alternative approaches to the generally adopted double-blind gold standard.Human decision and its ensuing practices play an important role in many domains of human endeavor. When decisions are taken such that their consequences are determinative for the health and care of sick people, an element of even greater importance is added. However, if compared to decision making in economics, psychology, cognitive science, or finance, medical decision making has not yet concentrated very much on structured decision model building [1, 2, 3, 4] 1 . Several reasons for this can be identified. First of all, decisions in medicine touch upon some of the most delicate and valued aspects of us as human beings, possibly also related to matters of life and death, and for this a structured theoretical modeling of their processes might seem almost impossible [5,6,7,8,9]. Secondly, very complicated ethical questions are connected with even simple decisions and their subsequent practices in medicine, which also seems to indicate that only highly contextual and ad hoc reasoning is at place [10,11,12]. Thirdly, and more generally, the concrete 1 Although we mention that the 'Society for Medical Decision Making' (http://smdm.org), with its peer reviewed journal, is an important forum for many of the delicate aspects related to medical decision making.