Numerical simulations of flow and heat transfer in an unsteady oscillatory fully developed combined convection are conducted. The temperature on the right wall varies with sinusoidal rhythm over time within a locked mean temperature, whereas the temperature on the left wall remains constant. Both walls are also considered to be stationary. A numerical solution for the momentum and energy equations obtained using the Runga- Kutta method is used to analyze the effect of periodic oscillation on the velocity and temperature configurations, as well as the progression of heat generations. The combined convection process of heat transfer and its flow pattern in a vertical channel is important in many applications, including environmental, industrial, and engineering. This study is prompted by a problem with the heat transfer process, which is difficult, expensive, and time-consuming. The purpose of this study is to develop a mathematical model, find a numerical solution, and conduct parametric studies on the double-diffusive fully developed vertical channel with unsteady oscillatory flow, as well as to investigate the effect of various parameters on the velocity and temperature profiles. The effect of different dimensional parameters is tested and the flow reversal phenomenon is discussed. The dimensional equations are transformed into non-dimensional equations using the similarity technique. Then, the built-in program dsolve in Maple is used to numerically solve the boundary value problem (BVP). A validation study is conducted on a previously reported problem to confirm the validity of the present calculation. The flow and temperature numerical findings are represented visually. It is found that a large development of flow is caused by the plate temperature oscillation with high amplitude, therefore, the nature of the flow differs from the non-oscillating case.