Double Early Epidermoid Carcinoma of the Esophagus in Columnar Epithelium

Resano, C. H.; Cabrera, Natalia González; Cueto, Daniel González; Basso, A. E. Sanchez; Rubio, Herrera

doi:10.1055/s-2007-1018461

Cited by 14 publications

(9 citation statements)

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“…It has been suggested to have developed initially as SCC, and then into ASC as a result of a subsequent occurrence of glandular metaplasia, or may also have been primarily an adenocarcinoma with areas of squamous metaplasia in tumor cell differentiation. 4,17 Some authors infer the collision concept, which hypothesizes that two individual stem cells may have simultaneously and independently undergo malignant Esophageal adenosquamous carcinoma 787 transformation. 5,18,19 However, some authors posited that the tumor may also have arisen from the mucous epithelium of a Barrett's esophagus.…”

Section: Discussionmentioning

confidence: 99%

Primary esophageal adenosquamous carcinoma: a retrospective analysis of 24 cases

et al. 2013

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Primary adenosquamous carcinoma (ASC) of the esophagus is a rare kind of malignancy characterized by mixed glandular and squamous differentiation as well as a propensity for aggressive clinical behavior. Data on the evaluation of the clinicopathological features and the prognosis of patients suffering from this malignancy are few because of the rarity of this disease. We conducted a retrospective review of 24 patients with primary esophageal ASC among 6546 esophageal cancer patients who underwent transthoracic esophagectomy in our hospital. The clinicopathological presentation, diagnosis, treatment, and prognostic factors of the patients were respectively investigated. The Kaplan-Meier method and the log rank test were used to calculate and compare overall survival (OS). The Cox proportional hazards model was employed to identify independent prognostic factors. There were 18 males and 6 females with a median age of 60 years (range: 40-78 years). The clinical symptoms, macroscopic type, as well as the radiological and endoscopic features of esophageal ASC were similar to those of esophageal squamous cell carcinoma. Sixteen (88.9%) of the 18 cases who underwent preoperative esophagoscopic biopsy were misdiagnosed as adenocarcinoma or squamous cell carcinoma. The overall median follow-up period was 36 months, and the median survival time was 32 months. The 1, 3, 5-year OS rates were 75.0%, 48.5%, and 19.4%, respectively. Univariate analysis showed that gender (P=0.047), lymph node metastasis (P=0.007), and TNM stage (P=0.037) were important factors associated with OS of the 22 patients who underwent radical resection. Multivariate analysis showed that the pathological N stage was the only independent prognostic factor (P=0.031, hazard ratio [HR], 5.369, 95% confidence interval [CI], 1.167-24.700). These results suggest that esophageal ASC is an uncommon disease prone to be misdiagnosed by endoscopic biopsy. Surgical resection is the primary treatment, but the prognosis of ASC is usually poorer than conventional squamous cell carcinoma. Lymph node metastasis is an independent prognostic factor after radical resection.

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Section: Discussionmentioning

confidence: 99%

Primary esophageal adenosquamous carcinoma: a retrospective analysis of 24 cases

et al. 2013

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“…Esophagitis has been reported in some patients with BN; however, Kiss et al suggested that chronic and self-induced vomiting rarely leads to mucosal injury [51]. Several case reports described Barrett's and carcinoma of the esophagus in patients with a prior history of BN or psychogenic vomiting [52,53]. Conversely, a recent study demonstrated that patients with ED had an increased risk of developing esophageal cancer but no cases were adenocarcinomas.…”

Section: Bulimia Nervosamentioning

confidence: 99%

Eating Disorders and Gastrointestinal Diseases

et al. 2019

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Eating disorders (ED) are frequently associated with a wide range of psychiatric or somatic comorbidities. The most relevant ED are anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorders (BED). Patients with ED exhibit both upper and lower gastrointestinal (GI) symptoms. Evidence of alterations throughout the GI tract in ED will be analyzed given the role of the GI tract in food intake and its regulation. It remains a matter of debate whether GI disorders are inherent manifestations of ED or the results of malnutrition occurring from ED. Moreover, recent clinical studies have highlighted the growing role of intestinal microbiota in the pathogenesis of ED, making it possible to hypothesize a modulation of intestinal microbiota as a co-adjuvant to standard therapy. The aim of this review is to analyze the link between ED and GI diseases and to present, where known, the potential key factors underlying these conditions. Conclusions: The presence of GI disorders should be investigated in patients with ED. Screening for ED should also be encouraged in individuals seeking treatment for unexplained GI complaints to better address therapeutic issues that surround these difficult medical conditions. Nutrients 2019, 11, 3038 3 of 17 ED can be associated with anxiety or mood disorders; insomnia; as well as somatic complications such as cardiac alterations, hormonal imbalances and also a wide range of gastrointestinal (GI) symptoms [3].Prevalence estimate of lifetime AN is 0.8% [4]. The overall incidence rate of AN is around 7 per 100,000 persons; however, it is higher in 15-19 year old girls reaching 109.2 cases per 100,000. The incidence is increasing in Italy and other Western countries probably due to earlier diagnosis or earlier onset [5,6].The prevalence of BN is 0.28% [4]. The highest incidence rate of BN is 300 per 100,000 persons in women aged between 16 and 20 [7], although the age at onset is decreasing [5].BED are described in 0.85% of the population [4,8] and are frequently associated with medical comorbidities, especially obesity and its complications such as Type II diabetes mellitus, hypertension, and dyslipidemia [9]. Furthermore, BED may occur in a subset ranging from 27% to 47% in severely obese persons undergoing bariatric surgery [10].The previous edition of DSM (DSM-IV) [11], classified as "Eating Disorders Not Otherwise Specified (EDNOS)", is the ED that does not satisfy all the diagnostic criteria for AN or BN. Previously, EDNOS contained a huge and varied group of individuals and was the most commonly diagnosed ED. However, the DSM-V revised this ED type and called it "Other Specified Feeding or Eating Disorder" (OSFED). Moreover, the DSM-V introduced the definition of Avoidant/restrictive food intake disorder (ARFID) that was distinct from AN and BN in that there is no body image disturbance [2].The first description of AN in the 19th century revealed that the sufferers' reasons for self-starvation generally were strictly connected to inappetence, feelings of fullness and abdominal ...

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“…Its histogenesis is controversial. The tumor may derive from Barrett's esophagus, or may have a mixed origin arising from both squamous and glandular epithelium simultaneously, or may be primarily an adenocarcinoma with areas of squamous metaplasia or primarily a squamous carcinoma with glandular metaplasia [15,16]. The absence of Barrett's esophagus around the tumor and the prevalent squamous structure suggest that the adenosquamous tumor had a unique origin from superficial esophageal epithelium.…”

Section: Discussionmentioning

confidence: 99%

Synchronous primary adenocarcinoma and adenosquamous carcinoma of the esophagus

et al. 2001

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Multiple malignant esophageal tumors of the same cell type are described. In the esophageal mucosa, widespread carcinomatous transformation may be observed and multicentric invasive squamous cell carcinomas may develop. The concomitance of two independent esophageal malignant neoplasms of different epithelial histogenesis is uncommon. Synchronous adenocarcinoma and squamous cell carcinoma of the esophagus is reported. Adenosquamous carcinoma of the esophagus is a rare tumor. Adenocarcinoma of the esophagus represents 10% of esophageal cancer. We report a case of a synchronous primary invasive adenosquamous carcinoma and adenocarcinoma of the esophagus. Both tumors were demonstrated radiographically. The peculiarity of this neoplastic association and the importance of complete radiographic esophageal evaluation in patients with one obvious obstructing tumor of the esophagus are emphasized.

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Double Early Epidermoid Carcinoma of the Esophagus in Columnar Epithelium

Cited by 14 publications

References 0 publications

Primary esophageal adenosquamous carcinoma: a retrospective analysis of 24 cases

Primary esophageal adenosquamous carcinoma: a retrospective analysis of 24 cases

Eating Disorders and Gastrointestinal Diseases

Synchronous primary adenocarcinoma and adenosquamous carcinoma of the esophagus

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