Double emulsions — scope, limitations and new achievements

Garti, Nissim

doi:10.1016/s0927-7757(96)03809-5

Cited by 316 publications

(210 citation statements)

References 25 publications

Supporting

Mentioning

201

Contrasting

Unclassified

Order By: Relevance

“…A multiple (double or complex) emulsion is an emulsion in an emulsion [1]. A W/O/W emulsion consists of water droplets dispersed within larger oil droplets, which are themselves dispersed in an aqueous continuous phase.…”

Section: Introductionmentioning

confidence: 99%

Production of multiple emulsions for drug delivery systems by repeated SPG membrane homogenization: Influence of mean pore size, interfacial tension and continuous phase viscosity

Vladisavljević

Shimizu²,

Nakashima³

2006

Journal of Membrane Science

115

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Production of multiple emulsions for drug delivery systems by repeated SPG membrane homogenization: Influence of mean pore size, interfacial tension and continuous phase viscosity

Vladisavljević

Shimizu²,

Nakashima³

2006

Journal of Membrane Science

115

View full text Add to dashboard Cite

“…Many formulation approaches have been deployed to improve stability 8,13 : sophisticated combinations of emulsifiers have been selected, the proportions of the two types of emulsifiers have been optimized, co-surfactants have been added… However, the complexity of their multi-step formulation route, the lack of control of emulsions morphology and encapsulation rate, as well as the necessity of using important amounts of surfactants to obtain stable multiple emulsions, are still a limitation to large-scale applications 14 .…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier

et al. 2016

View full text Add to dashboard Cite

show abstract

“…29 Such phase inversion of Pickering emulsions has been exploited to prepare so-called double emulsions. 30 For example, gently emulsifying a w/o emulsion with a second aqueous phase can lead to a w/o/w double emulsion. 31 Alternatively, the complementary o/w/o double emulsion can be prepared by first making an o/w emulsion, followed by re-emulsification in the presence of further oil (which forms the continuous phase).…”

Section: Introductionmentioning

confidence: 99%

Preparation of Double Emulsions using Hybrid Polymer/Silica Particles: New Pickering Emulsifiers with Adjustable Surface Wettability

Williams

Warren

Fielding

et al. 2014

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Abstract.A facile route for the preparation of water-in-oil-in-water (w/o/w) double emulsions is described for three model oils, namely n-dodecane, isopropyl myristate and isononyl isononanoate, using fumed silica particles coated with poly(ethylene imine) (PEI). The surface wettability of such hybrid PEI/silica particles can be systematically adjusted by (i) increasing the adsorbed amount of PEI and (ii) addition of 1-undecanal to the oil phase prior to homogenization. In the absence of this long-chain aldehyde, PEI/silica hybrid particles (PEI/silica mass ratio = 0.50) produce o/w Pickering emulsions in all cases. In the presence of 1-undecanal, this reagent reacts with the primary and secondary amine groups on the PEI chains via Schiff base chemistry, which can render the PEI/silica hybrid particles sufficiently hydrophobic to stabilize w/o Pickering emulsions at 20 o C. Gas chromatography, 1 H NMR and x-ray photoelectron spectroscopy provide compelling experimental evidence for this in situ surface reaction, while a significant increase in the water contact angle indicates markedly greater hydrophobic character for the PEI/silica hybrid particles. However, when PEI/silica hybrid particles are prepared using a relatively low adsorbed amount of PEI (PEI/silica mass ratio = 0.075) only o/w Pickering emulsions are obtained, since the extent of surface modification achieved using this Schiff base chemistry is insufficient. Fluorescence microscopy and laser diffraction studies confirm that highly stable w/o/w double emulsions can be achieved for all three model oils. This is achieved by first homogenizing the relatively hydrophobic PEI/silica hybrid particles (PEI/silica mass ratio = 0.50) with an oil containing 3 % 1-undecanal to form an initial w/o emulsion, followed by further homogenization using an aqueous dispersion of relatively hydrophilic PEI/silica particles (PEI/silica mass ratio = 0.075).Dye release from the internal aqueous cores into the aqueous continuous phase was monitored by visible absorption spectroscopy. These studies indicate immediate loss of 12-18 % dye during the high speed homogenization that is required for double emulsion formation, but no further dye release is observed at 20 °C for at least 15 days thereafter.

show abstract

Double emulsions — scope, limitations and new achievements

Cited by 316 publications

References 25 publications

Production of multiple emulsions for drug delivery systems by repeated SPG membrane homogenization: Influence of mean pore size, interfacial tension and continuous phase viscosity

Production of multiple emulsions for drug delivery systems by repeated SPG membrane homogenization: Influence of mean pore size, interfacial tension and continuous phase viscosity

Biocompatible Stimuli-Responsive W/O/W Multiple Emulsions Prepared by One-Step Mixing with a Single Diblock Copolymer Emulsifier

Preparation of Double Emulsions using Hybrid Polymer/Silica Particles: New Pickering Emulsifiers with Adjustable Surface Wettability

Contact Info

Product

Resources

About