Double Exponential Dendrimer Growth

Kawaguchi, Tohru; Walker, Kathleen L.; Wilkins, Charles L.; Moore, Jeffrey S.

doi:10.1021/ja00113a005

Cited by 237 publications

(148 citation statements)

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“…13). Since then, the vicinity of g max and the SIS were invoked to rationalize deviations of observed MM from their ideal values 31,32 , as well as synthesis failures [33][34][35] . It was also discussed as a design guideline for controlling the accessibility of the dendritic interior to guest molecules 36,37 .…”

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confidence: 99%

Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

Zhang

Schlüter

et al. 2013

Nat Commun

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Classical theory predicts that branching defects are unavoidable in large dendritic molecules when steric congestion is important. Here we report first experimental evidence of this effect via labelling measurements of an extended homologous series of generations g ¼ 1y6 of dendronized polymers. This system exhibits a single type of defect interrogated specifically by the Sanger reagent thus permitting to identify the predicted upturn in the number of branching defects when g approaches g max and the polymer density approaches close packing. The average number of junctions and defects for each member of the series is recursively obtained from the measured molar concentrations of bound labels and the mass concentrations of the dendritic molecules. The number of defects increases at g ¼ 5 and becomes significant at g ¼ 6 for dendronized polymers where the g max was estimated to occur at 6.1 rg max r 7.1. The combination of labelling measurements with the novel theoretical analysis affords a method for characterizing high g dendritic systems.

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confidence: 99%

Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

Zhang

Schlüter

et al. 2013

Nat Commun

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“…In addition to the divergent and convergent approaches, various alternative preparation methods have been developed that aim to reduce the number of synthetic and purification steps and increase yields, such as the double-stage convergent growth approach 17 , double-exponential dendrimer growth approach 18 and orthogonal coupling 19 .…”

Section: Divergent Methodmentioning

confidence: 99%

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2013

IJPSR

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Dendrimers are highly branched and reactive threedimensional macromolecules, with all bonds emanating from a central core. Compared with traditional linear polymers, Dendrimers have much more accurately controlled structures, with a globular shape, a single molecular weight rather than a distribution of molecular weights, and a large number of controllable "peripheral" functionalities. All these versatile features of dendrimers have made their application in various areas like Biomimetic, Pharmaceutical drug delivery, Gene delivery, Chemotherapy and Diagnostics very attractive. This review briefly discusses different types of dendrimers with their structures and their methods preparations. We have emphasized on applications of dendrimers.

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“…This approach, termed double exponential growth [81][82][83], is illustrated for polyester dendrimers in Scheme 3 [84]. In this methodology, both components for formation of the higher generation structure, the polyol and the carboxylic acid for polyester dendrimers, are prepared using a single starting material.…”

Section: Dendrimersmentioning

confidence: 99%

Polyester Dendrimers

Twibanire

Grindley

2012

Polymers

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Polyester dendrimers have been comprehensively reviewed starting from their first synthesis in the early 1990s by Hawker and Fréchet. Polyester dendrimers have attracted and continue to attract extensive interest because they are comparatively easy to make and because, whenever they have been tested, they have been found to be non-toxic. A number of different strategies for their synthesis have been examined and the methods employed for formation of the ester bond during dendrimer assembly have been summarized. The newest approaches, including the use of bifunctional orthogonally reacting dendrons and accelerated synthesis have been surveyed.

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Double Exponential Dendrimer Growth

Cited by 237 publications

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Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

Synthetic regimes due to packing constraints in dendritic molecules confirmed by labelling experiments

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Polyester Dendrimers

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