Double Exponential Nature in Chromium-51 Red Blood Cell Survival Curves in Hæmoglobin E Thalassæmia and Relation with Reticulocytes

The Distribution of Hemoglobin Types in Thalassemic Erythrocytes*

“…This variability, evident at mere examination of red cell morphology, has been supported by the early studies on red cell survival, which showed that the red cell population contains very short-living as well as rather longliving cells (1). Essentially similar findings were obtained in some studies by using chromated erythrocytes (2,3); in other studies no initial rapid fall of the chromium survival curve was observed, but there was indirect evidence compatible with the presence of a very short-lived population of red cells (4). Support for heterogeneity has also been obtained by the technique for the histochemical demonstration of hemoglobin F (5), all reports agreeing on the nonuniform distribution of fetal hemoglobin over the red cell population (6)(7)(8).…”

Substitutive-Inhibitory Therapy in Constitutional Non-Spherocytic Erythrocytic Disease

“…c) M any abortive forms never reach peripheral blood and numerous nucleated and reticulated red cells remain very shortly (hours) in circulation (infant mortality theory), as indicated by early labelled bile pigment (6) and the double exponential nature of Cr51-erythrocyte survival curves (7). d) By-products during states of erythropoietic acceleration may accentuate the metabolic effort (8,9).…”