Double-flash electroretinography in human eyes

Kooijman, Aart C.; Zwarts, J; Damhof, A

doi:10.1007/bf00154493

Cited by 4 publications

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“…From this finding, and because normally the suppression of the second response to double flashes presented in the dark is in human subjects mediated through the rod system [9], as in the cat [3], we assume that the PERRS in our patients is not primarily the result of lack of cones.…”

Section: Discussionmentioning

confidence: 92%

“…As the suppression effect of the b-wave in the normal retina of cats [3] and humans [9] is a rod-driven process, in the first instance a defect of the rod-driven process seems likely in our patients. A hypothesis might be that the restorative reactions to phototransduction in the rods are slackened [19].…”

Section: Discussionmentioning

confidence: 99%

“…With this method the influence of preceding stimuli or preceding responses on the excitability of retinal receptors and neuroretinal cells can be studied. Results of measurements in cats [1][2][3], rabbits [4][5][6], frogs [5] and normal human eyes [7][8][9], with and without the use of agonistic or antagonistic drugs, have been published in the last 40 years. In a recent study on patients with Parkinson's disease, decreased suppression of the responses to the test flashes compared to suppression in matched normal subjects was found [10].…”

Section: Introductionmentioning

confidence: 99%

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Prolonged Electro-Retinal Response Suppression (PERRS) in patients with stationary subnormal visual acuity and photophobia

et al. 1991

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Neural adaptation to light stimulation in the dark-adapted retina can be demonstrated by double-flash electroretinography. The first flash is a conditioning flash, the second flash is the test flash. Interstimulus intervals are in the range of 0.2 to 30 seconds. Suppression of the response to the test flash is assumed not to be related to photopigment regeneration, as in normal human subjects the recovery after strong conditioning flashes is completed in about 2 seconds. In this paper we demonstrate the results of double-flash electroretinography on four patients, two of whom are brother and sister. Each of them showed a five- to ten-fold prolonged suppression time compared to normal measurements. Clinical aspects of all the patients were a stationary, though fluctuating, subnormal visual acuity of about 0.5, some photophobia, and difficulties in adaptation to changes in luminance levels. We assume that the PERRS indicates changes in the restorative reactions to phototransduction in the photoreceptors, or in the neural transmission mechanism, either in the rod-driven lateral inhibitory neural processes or in the cone-driven rod inhibitory processes, caused by a cone dysfunction.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prolonged Electro-Retinal Response Suppression (PERRS) in patients with stationary subnormal visual acuity and photophobia

et al. 1991

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Repeated-fl ash (double-fl ash) electroretinography (ERG) has been used to study retinal function in normal subjects [1][2][3][4][5][6][7][8][9] and in patients with various retinal diseases. [10][11][12][13][14][15] Most of repeated-fl ash ERG investigations have analyzed a and b waves, although some 1-7 have observed the behavior of oscillatory potentials (OPs), which appear on the ascending portion of the b wave as a series of small wavelets.

Amplitude and implicit time of OPs are infl uenced by retinal adaptation.

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confidence: 99%

Oscillatory potentials with repeated-flash electroretinography

et al. 2010

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Sutter

2000

Documenta Ophthalmologica

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The interpretation of binary kernels derived by means of the mulifocal ERG has frequently been the source of confusion and controversy. The aim of this paper is to provide an intuitive understanding of the concept of kernels and to demonstrate with models and examples, the relationship between the kernels and individual responses. The sample data used to illustrate the various aspects of the technique were derived and analyzed by means of the multifocal VERIS instrument using bipolar Burian-Allen contact lens electrodes. From the kernel data, response waveforms are synthesized that can be readily compared with those obtained with conventional flash, double flash and multi-flash ERG techniques. From the kernels of a single multifocal record, waveforms are synthesized that describe responses at various times after a preceding focal flash. It is shown that the observed adaptive changes in the waveforms depend not only on the flash interval but also on retinal eccentricity. Features on the response waveform exhibit independent adaptive behavior suggesting that they originate from different retinal sources. On one hand, the examples presented here illustrate the rich information on retinal dynamics contained in the kernels. On the other hand, they demonstrate how the interpretation of multifocal data can be facilitated when the kernel series is transformed into representations with more direct physiological appeal.

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Double-flash electroretinography in human eyes

Cited by 4 publications

References 14 publications

Prolonged Electro-Retinal Response Suppression (PERRS) in patients with stationary subnormal visual acuity and photophobia

Prolonged Electro-Retinal Response Suppression (PERRS) in patients with stationary subnormal visual acuity and photophobia

Oscillatory potentials with repeated-flash electroretinography

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