Double-headed nucleosides: Synthesis and applications

Abstract

Double-headed nucleoside monomers have immense applications for studying secondary nucleic acid structures. They are also well-known as antimicrobial agents. This review article accounts for the synthetic methodologies and the biological applications of double-headed nucleosides.

Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

“…More specifically, there is still a need to accelerate new research for discovering anti-HIV agents that feature novel mechanisms of action and can work against drug resistance phenomena. The significance of more creative and easy procedures to access not only 1,3-oxathiolane nucleosides but various nucleoside molecules with desired structural modifications is still a major challenge for synthetic chemists [ 89 – 90 ]. On the grounds of this, synthetic nucleoside analogues have found an application in rational biomolecular designing as well as in medicinal chemistry [ 90 ].…”

“…The significance of more creative and easy procedures to access not only 1,3-oxathiolane nucleosides but various nucleoside molecules with desired structural modifications is still a major challenge for synthetic chemists [ 89 – 90 ]. On the grounds of this, synthetic nucleoside analogues have found an application in rational biomolecular designing as well as in medicinal chemistry [ 90 ]. These modified 1,3-oxathiolane nucleosides could be transformed into oligonucleotides to investigate the potential to act as antisense nucleosides.…”

Replacement of the phosphodiester backbone between canonical nucleosides with a dirhenium carbonyl “click” linker—a new class of luminescent organometallic dinucleoside phosphate mimics

“…[4][5][6][7][8] Structural alterations of canonical nucleic acid components pertains to the modification of the nucleobase, the (deoxy)ribose and the phosphodiester backbone. 1,2,[9][10][11] In the case of the phosphodiester backbone, three general classes of modifications can be distinguished. The first class comprises the substitution of the nonbonding oxygen atom in the phosphodiester backbone.…”

Synthesis of 1,2,3‐Triazole‐Linked Hexopyranosylpyrimidine Nucleosides and Their Application as Hepatitis B Viral DNA, HBsAg and HBeAg Suppressants

“…1,2,3-triazole derivatives have ability to form different noncovalent interactions with different biological targets due to which they possess wide range of biological applications. [1][2][3][4][5][6][7][8] Nucleosides and their analogues with modified sugars and bases [9][10][11] also display a broad range of activities, such as, anticancer, [12] anti-HIV, [13] anti-HBV [14] (hepatitis B virus), anti-HCV [15] (hepatitis C virus) and antiproliferative. [16] Five/six membered triazole nucleosides synthesized as a result of copper(I)-catalyzed 1,3-dipolar cycloaddition reaction between sugar azides and propargylated nucleobases are therefore of special interest due to their prominent biological activities.…”