Double hits with bioactive nanozyme based on cobalt-doped nanoglass for acute and diabetic wound therapies through anti-inflammatory and pro-angiogenic functions

Mandakhbayar, Nandin; Ji, YunSeong; El-Fiqi, Ahmed; Patel, Kapil D.; Yoon, Dong Suk; Dashnyam, Khandmaa; Bayaraa, Oyunchimeg; Jin, Gangshi; Tsogtbaatar, Khaliunsarnai; Kim, Tae-Hyun; Lee, Jung-Hwan; Kim, Hae-Won

doi:10.1016/j.bioactmat.2023.08.014

Cited by 16 publications

(8 citation statements)

References 59 publications

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“…Although cobalt-based nanoparticles have certain concentration-dependent toxicity and potential genetic damage, the application of cobalt-based nanoparticles in antibacterial and orthopedic biomaterials has been explored for a long time. In order to ensure that the concentration of cobalt ions is controlled within the biosafety range, we studied the cytotoxicity of CoS nanospheres to evaluate their biosafety in the treatment of wound infection. ,− The survival rate of L929 cells treated with different concentrations of CoS nanospheres was determined by a cell survival staining kit and cell counting kit (CCK-8). CoS nanospheres up to 50 μg/mL showed negligible cytotoxicity in live-dead staining and CCK-8 assay (Figure S4).…”

Section: Resultsmentioning

confidence: 99%

Hollow Cobalt Sulfide Nanospheres with Highly Enzyme-like Antibacterial Activities to Accelerate Infected Wound Healing

Wu,

Liu,

Huang

et al. 2023

Bioconjugate Chem.

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The emergence of nanozymes presents a promising alternative to antibiotics for reactive oxygen species-mediated broad-spectrum antimicrobial purposes, but nanozymes still face challenges of low therapeutic efficiency and poor biocompatibility. Herein, we creatively prepared a novel kind of hollow cobalt sulfide (CoS) nanospheres with a unique mesoporous structure that is able to provide numerous active sites for enzyme-like reactions. The results revealed that 50 μg/mL of CoS nanospheres exhibited strong peroxidase- and oxidase-like activities under physiological conditions with the assistance of a low concentration of hydrogen peroxide (H2O2, 100 μM) while possessing highly efficient GSH-depletion ability, which endowed CoS nanospheres with triple enzyme-like properties to combat bacterial infections. The in vitro experiments demonstrated that the CoS nanozyme displayed significant antibacterial effects against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). The in vivo implantation showed that the synthesized CoS effectively eliminated bacteria and promoted the recovery of infected wounds in rats while exhibiting a low cytotoxicity. This study provides a promising treatment strategy to accelerate infected wound healing.

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Section: Resultsmentioning

confidence: 99%

Hollow Cobalt Sulfide Nanospheres with Highly Enzyme-like Antibacterial Activities to Accelerate Infected Wound Healing

Wu,

Liu,

Huang

et al. 2023

Bioconjugate Chem.

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“…The in vivo efficacy of MNC/GelMA hybrid hydrogel was tested using full-thickness skin defect modeled in mice . The choice of this animal model was based on its close resemblance to human wound healing processes, allowing for an accurate assessment of the therapeutic potential of hybrid hydrogels in a physiologically relevant context .…”

Section: Methodsmentioning

confidence: 99%

“…The in vivo efficacy of MNC/GelMA hybrid hydrogel was tested using full-thickness skin defect modeled in mice. 36 The choice of this animal model was based on its close resemblance to human wound healing processes, allowing for an accurate assessment of the therapeutic potential of hybrid hydrogels in a physiologically relevant context. 37 All the experiments were conducted following the protocols approved by the Animal Care and Use Committee at Dankook University, Republic of Korea (approval no: DKU-18-032).…”

Section: Oxidative Stress Assay and Intracellular Ros Detectionmentioning

confidence: 99%

Multifunctional Molybdenum-Based Nanoclusters Engineered Gelatin Methacryloyl as In Situ Photo-Cross-Linkable Hybrid Hydrogel Dressings for Enhanced Wound Healing

Kurian,

Mandakhbayar,

Singh

et al. 2024

ACS Appl. Mater. Interfaces

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“…Drug-free therapies based on nanozymes with antioxidant enzyme activity to eliminate inflammation and promote angiogenesis, accompanied by fewer side effects and complications, are undoubtedly ideal options. 187 Considering the high-inflammatory environment of diabetic wounds and the side effects of anti-inflammatory drugs, Ji et al 188 recently proposed a novel bioactive nanozyme based on cobalt-doped nanoglasses (CoNZ), which exhibited a high enzyme/catalytic activity while releasing therapeutic ions. The ion-doped bioactive glass released ions with anti-inflammatory and pro-angiogenic properties and directed stem cell profiles, thereby accelerating the wound healing process accompanied by few complications and drug resistance.…”

Section: Anti-inflammatorymentioning

confidence: 99%

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Xiao,

Zhao,

DuBois

et al. 2024

ACS Biomater. Sci. Eng.

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Diabetic foot ulcers (DFU) are chronic, refractory wounds caused by diabetic neuropathy, vascular disease, and bacterial infection, and have become one of the most serious and persistent complications of diabetes mellitus because of their high incidence and difficulty in healing. Its malignancy results from a complex microenvironment that includes a series of unfriendly physiological states secondary to hyperglycemia, such as recurrent infections, excessive oxidative stress, persistent inflammation, and ischemia and hypoxia. However, current common clinical treatments, such as antibiotic therapy, insulin therapy, surgical debridement, and conventional wound dressings all have drawbacks, and suboptimal outcomes exacerbate the financial and physical burdens of diabetic patients. Therefore, development of new, effective and affordable treatments for DFU represents a top priority to improve the quality of life of diabetic patients. In recent years, nanozymes-based diabetic wound therapy systems have been attracting extensive interest by integrating the unique advantages of nanomaterials and natural enzymes. Compared with natural enzymes, nanozymes possess more stable catalytic activity, lower production cost and greater maneuverability. Remarkably, many nanozymes possess multienzyme activities that can cascade multiple enzymecatalyzed reactions simultaneously throughout the recovery process of DFU. Additionally, their favorable photothermal-acoustic properties can be exploited for further enhancement of the therapeutic effects. In this review we first describe the characteristic pathological microenvironment of DFU, then discuss the therapeutic mechanisms and applications of nanozymes in DFU healing, and finally, highlight the challenges and perspectives of nanozyme development for DFU treatment.

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Double hits with bioactive nanozyme based on cobalt-doped nanoglass for acute and diabetic wound therapies through anti-inflammatory and pro-angiogenic functions

Cited by 16 publications

References 59 publications

Hollow Cobalt Sulfide Nanospheres with Highly Enzyme-like Antibacterial Activities to Accelerate Infected Wound Healing

Hollow Cobalt Sulfide Nanospheres with Highly Enzyme-like Antibacterial Activities to Accelerate Infected Wound Healing

Multifunctional Molybdenum-Based Nanoclusters Engineered Gelatin Methacryloyl as In Situ Photo-Cross-Linkable Hybrid Hydrogel Dressings for Enhanced Wound Healing

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

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