Image security is a hot topic in the era of Internet and big data. Hyperchaotic image encryption, which can effectively prevent unauthorized users from accessing image content, has become more and more popular in the community of image security. In general, such approaches conduct encryption on pixel-level, bit-level, DNA-level data or their combinations, lacking diversity of processed data levels and limiting security. This paper proposes a novel hyperchaotic image encryption scheme via multiple bit permutation and diffusion, namely MBPD, to cope with this issue. Specifically, a four-dimensional hyperchaotic system with three positive Lyapunov exponents is firstly proposed. Second, a hyperchaotic sequence is generated from the proposed hyperchaotic system for consequent encryption operations. Third, multiple bit permutation and diffusion (permutation and/or diffusion can be conducted with 1–8 or more bits) determined by the hyperchaotic sequence is designed. Finally, the proposed MBPD is applied to image encryption. We conduct extensive experiments on a couple of public test images to validate the proposed MBPD. The results verify that the MBPD can effectively resist different types of attacks and has better performance than the compared popular encryption methods.