Double inherited thrombophilias and adverse pregnancy outcomes: Fashion or science?

Abstract

It seems that some thrombophilias and a combination of thrombophilic factors carry a greater risk than others for a given adverse outcome. Further studies are needed to check the link between thrombophilic gene mutations and adverse pregnancy outcomes, such as recurrent miscarriages and deep venous thrombosis.

New Insights into the Diagnosis and Management of Pregnancy-Related Diabetes Insipidus

“…Recent studies hypothesized genetic predisposition as a risk factor for HELLP syndrome, mainly under the form of various disturbances in the process of blood coagulation. Therefore, some clinical studies investigated the association between hereditary thrombophilia and HELLP syndrome but results remain controversial (Ganzevoort et al, 2007;Larciprete et al, 2010). Several reports confirmed statistically higher incidence of antithrombin-III deficiency in patients with HELLP syndrome (Larciprete et al, 2010;Dogan et al, 2011).…”

“…Therefore, some clinical studies investigated the association between hereditary thrombophilia and HELLP syndrome but results remain controversial (Ganzevoort et al, 2007;Larciprete et al, 2010). Several reports confirmed statistically higher incidence of antithrombin-III deficiency in patients with HELLP syndrome (Larciprete et al, 2010;Dogan et al, 2011). Apparently, women with elevated antiphospholipid antibodies titers are at risk to develop severe preeclampsia and HELLP syndrome (Heilmann et al, 2011).…”

Thrombophilia and Pregnancy

“…Так, например, ком-бинация мутации гена MTHFR C677T с PAI-1 (4G/4G) демонстрирует высокую корреляцию с внутри-утробной гибелью плода. Комбинация с мутацией FVL увеличивает риск невынашивания, причем главным образом до 12 нед., а сочетание с мутацией фактора VIII -с отслойкой плаценты [32,33].…”

Anticoagulants in obstetrics

“…Так, некоторыми авторами была выявлена связь между наличием у беременной двух наследственных тромбо-филических мутаций и риском ряда осложнений: MTHFR C677T & MTHFR A1298C ассоциировались с СЗРП, MTHFR C677T & PAI -с антенатальной гибелью плода, MTHFR C677T & factor VIII -с отслойкой плаценты, Factors VIII & X -с HELLP-синдромом [21].…”