Double-layered PLGA/HA microneedle systems as a long-acting formulation of polyphenols for effective and long-term management of atopic dermatitis

Chen, Yilun; Chang, Chih‐Han; Lin, Y. C.; Chen, Mei-Chin

doi:10.1039/d3bm00182b

Cited by 16 publications

(7 citation statements)

References 44 publications

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“…Soluble materials include HA, 104,105 PVP, 106,107 PVA, 107 and phthalate cellulose. 68 Biodegradable materials include PLA, PLGA, 108–110 GelMA, 111 HAMA, 69,112 CMCSMA, CMCMA, DexMA, and SilMA (Table 2).…”

Section: Microneedlementioning

confidence: 99%

Applications and prospects of microneedles in tumor drug delivery

Zhang,

Liu,

2024

J. Mater. Chem. B

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Section: Microneedlementioning

confidence: 99%

Applications and prospects of microneedles in tumor drug delivery

Zhang,

Liu,

2024

J. Mater. Chem. B

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“…Atopic dermatitis is a chronic inflammatory skin disease that requires long-term treatment to effectively control the symptoms [ 118 ]. Chen et al reported a double-layered PLGA/HA MNs for sustained delivery of polyphenols, curcumin (CUR), and gallic acid (GA) [ 78 ]. When applied, the HA layer could quickly dissolve and release GA, while the PLGA tips-layer could provide sustained release of CUR for 2 months.…”

Section: Application Of Long-acting Polymeric Microneedlesmentioning

confidence: 99%

Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery

Meng,

Qiao,

Xin

et al. 2024

J. pharm. pharm. sci.

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Microneedle (MN)-assisted drug delivery technology has gained increasing attention over the past two decades. Its advantages of self-management and being minimally invasive could allow this technology to be an alternative to hypodermic needles. MNs can penetrate the stratum corneum and deliver active ingredients to the body through the dermal tissue in a controlled and sustained release. Long-acting polymeric MNs can reduce administration frequency to improve patient compliance and therapeutic outcomes, especially in the management of chronic diseases. In addition, long-acting MNs could avoid gastrointestinal reactions and reduce side effects, which has potential value for clinical application. In this paper, advances in design strategies and applications of long-acting polymeric MNs are reviewed. We also discuss the challenges in scale manufacture and regulations of polymeric MN systems. These two aspects will accelerate the effective clinical translation of MN products.

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“…Nonetheless, the QU-NPs and MVs-QU-NPs groups demonstrated a significant sustained release effect over time, yielding cumulative release rates of about 82.95% and 77.68%, respectively, after 24 h of measurement. This prolonged and sustained drug release was attributed to PLGA polymers and macrophage membrane coated on the surface, which serves as a diffusional barrier to QU release [29,30].…”

Section: Drug Release Studymentioning

confidence: 99%

Quercetin-loaded PLGA nanoparticles coating with macrophage membranes for targeted delivery in acute liver injury

Shang,

Liang,

Wei

et al. 2023

Nanotechnology

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Quercetin (QU), a natural flavonoid with potent anti-inflammatory and antioxidant properties, holds promise in treating acute liver injury (ALI). Nonetheless, its limited solubility hampers its efficacy, and its systemic distribution lacks targeting, leading to off-target effects. To address these challenges, we developed macrophage membrane-coated quercetin-loaded PLGA nanoparticles (MVs-QU-NPs) for active ALI targeting. The resulting MVs-QU-NPs exhibited a spherical morphology with a clear core–shell structure. The average size and zeta potential were assessed as 141.70 ± 0.89 nm and –31.83 ± 0.76 mV, respectively. Further studies revealed sustained drug release characteristics from MVs-QU-NPs over a continuous period of 24 h. Moreover, these MVs-QU-NPs demonstrated excellent biocompatibility when tested on normal liver cells. The results of biodistribution analysis in ALI mice displayed the remarkable ALI-targeting ability of MVs-DiD-NPs, with the highest fluorescence intensity observed in liver tissue. This biomimetic approach combining macrophage membranes with nanoparticle delivery, holds great potential for targeted ALI treatment.

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Double-layered PLGA/HA microneedle systems as a long-acting formulation of polyphenols for effective and long-term management of atopic dermatitis

Abstract: Atopic dermatitis (AD) is a chronic, relapsing inflammatory disorder that requires long-term treatment to achieve optimal control. Topical corticosteroids or calcineurin inhibitors are the mainstay of treatment, but the safety...

Cited by 16 publications

References 44 publications

Applications and prospects of microneedles in tumor drug delivery

Applications and prospects of microneedles in tumor drug delivery

Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery

Quercetin-loaded PLGA nanoparticles coating with macrophage membranes for targeted delivery in acute liver injury

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