Double Lung Transplantation for Adult Respiratory Distress Syndrome After Recombinant Interleukin 2

Brichon, Pierre Yves; Barnoud, D.; Pison, Christophe; Pérez, Ignacio Sánchez; Guignier, M

doi:10.1378/chest.104.2.609

Cited by 18 publications

(12 citation statements)

References 6 publications

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“…As for COVID‐19‐associated ARDS, published cases are older (62.8 ± 9.6 years) 17–19 . Similar to our study, previously reported recipients required ECMO support as a bridge to transplantation in 20 out of 23 cases (87.0%) 10–12,14–20 . The survival outcome reported by Chang and colleagues was similar to that observed in this study, and the 1‐year survival rate post‐transplantation was reported as 78.0% 20 .…”

Section: Discussionsupporting

confidence: 89%

“…To date, there is no published data that summarizes the outcome of lung transplantation for ARDS using the UNOS database. There are 10 published case reports 10–19 and 1 case series 20 regarding lung transplantation for patients with ARDS, including 1 case of H1N1 influenza, 12 1 of Paraquat‐induced lung injury, 13 and 5 of inhalation lung injury 20 . Increasing case reports are being published regarding COVID‐19‐associated ARDS 17–19 .…”

Section: Discussionmentioning

confidence: 99%

“…Historically, lung transplantation for ARDS has been offered to relatively young recipients before the emergence of COVID‐19. The recipient age of reported cases prior to cases of COVID‐19 were 35.7 ± 13.9 years 10–16 . As for COVID‐19‐associated ARDS, published cases are older (62.8 ± 9.6 years) 17–19 .…”

Section: Discussionmentioning

confidence: 99%

“…However, there remains a substantial number of patients who may benefit from a lung transplant, such as those with persistent ARDS who are unable to recover while on ECMO or mechanical ventilatory support due to devastating lung injuries, as well as patients with chronic pulmonary symptoms after recovery when bronchiectasis and pulmonary fibrosis persist on chest CT 6 . To date, the literature consists of 10 case reports 10–19 and 1 single‐center case series 20 primarily focusing on the use of lung transplantation as a life‐saving treatment in the setting of ARDS. The largest single‐center case series report from South Korea found a reasonable long‐term outcome after lung transplantation for ARDS with a 3‐year survival rate of 78% 20 .…”

Section: Introductionmentioning

confidence: 99%

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Lung transplantation for the treatment of irreversible acute respiratory distress syndrome

Harano

Ryan

Chan

et al. 2020

Clinical Transplantation

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Background Despite advances in critical care for acute respiratory distress syndrome (ARDS), some survivors in the acute phase are unable to wean from extracorporeal membrane oxygenation (ECMO) or mechanical ventilation. To date, little is known regarding whether lung transplantation confers a survival benefit for irreversible ARDS. Methods This retrospective study was conducted using the United Network for Organ Sharing database (May 2005–December 2018). Patients with restrictive lung disease were divided into two groups: patients with and without ARDS. Propensity score matching identified recipients without ARDS for the control group. Results A total of 63 patients with ARDS were waitlisted for lung transplantation, while 39 received a lung transplant after a median waitlist duration of 8 days. Seventy‐eight patients were matched as controls. In the ARDS group, the median age was 30 years, and the median lung allocation score was 88.4. Among the 39 recipients, 30 (76.9%) received ECMO support prior to transplantation. Lung transplantation for ARDS and restrictive lung disease showed similar 90‐day (87.2% vs. 88.5%, p = .80), 1‐year (82.1% vs. 85.9%, p = .52), and 3‐year (69.2% vs. 65.4%, p = .94) survival rates. Conclusions Lung transplantation provides acceptable outcomes in selected patients with irreversible ARDS.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lung transplantation for the treatment of irreversible acute respiratory distress syndrome

Harano

Ryan

Chan

et al. 2020

Clinical Transplantation

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“…Lung transplantation, although previously reported, is an uncommon rescue intervention in cases of severe ARDS. [ 23 ] It was utilized in one patient in our study who could not be liberated from ECMO. Its utility as a salvage therapy for ARDS after prolonged ECMO requires further clarification and study.…”

Section: Discussionmentioning

confidence: 99%

Critical illness associated with 2013-2014 influenza A (H1N1): Postpandemic characteristics, presentation and outcomes

Wiesen¹,

Joshi²,

Guzmán³

et al. 2015

Indian Journal of Critical Care Medicine

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Introduction:The United States experienced a postpandemic outbreak of H1N1 influenza in 2013–2014. Unlike the pandemic in 2009 clinical course and outcomes associated with critical illness in this postpandemic outbreak has been only sparsely described.Methods:We conducted a retrospective analysis of all patients admitted to the Medical Intensive Care Unit with H1N1 influenza infection in 2009–2010 (pandemic) and 2013–2014 (postpandemic).Results:Patients admitted in the postpandemic period were older (55 ± 13 vs. 45 ± 12, P = 0.002), and had a higher incidence of underlying pulmonary (17 vs. 7, P = 0.0007) and cardiac (16 vs. 8, P = 0.005) disease. Mechanical ventilation was initiated in most patients in both groups (27 vs. 21, P = 1.00). The PaO2/FiO2 ratio was significantly higher in the pandemic group on days 1 (216 vs. 81, P = 0.0009), 3 (202 ± 99 vs. 100 ± 46, P = 0.002) and 7 (199 ± 103 vs. 113 ± 44, P = 0.019) but by day 14 no difference was seen between the groups. Rescue therapies were used in more patients in the postpandemic period (48% vs. 20%, P = 0.028), including more frequent use of prone ventilation (10 vs. 3, P = 0.015), inhaled vasodilator therapy (11 vs. 4, P = 0.015) and extracorporeal membrane oxygenation (ECMO) (4 vs. 2, P = NS). No significant differences in mortality were seen between the two cohorts.Conclusions:Compared to the 2009–2010 pandemic, the 2013–2014 H1N1 strain affected older patients with more underlying co-morbid cardio-pulmonary diseases. The patients had worse oxygenation indices and rescue modalities such as prone ventilation, inhaled epoprostenol and ECMO, were used more consistently as compared to the 2009 pandemic.

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Cytokine-Networks and ARDS

Jorens¹,

Bossaert²

1997

Yearbook of Intensive Care and Emergency Medicine

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Double Lung Transplantation for Adult Respiratory Distress Syndrome After Recombinant Interleukin 2

Cited by 18 publications

References 6 publications

Lung transplantation for the treatment of irreversible acute respiratory distress syndrome

Lung transplantation for the treatment of irreversible acute respiratory distress syndrome

Critical illness associated with 2013-2014 influenza A (H1N1): Postpandemic characteristics, presentation and outcomes

Cytokine-Networks and ARDS

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