Double Lung Transplants Have Significantly Improved Survival Compared With Single Lung Transplants in High Lung Allocation Score Patients

Black, Matthew C.; Trivedi, Jaimin R.; Schumer, Erin M.; Bousamra, Michael; Berkel, Victor van

doi:10.1016/j.athoracsur.2014.05.072

Cited by 23 publications

(14 citation statements)

References 5 publications

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“…Our study confirmed previous findings that RRT and post‐LTx use of ECMO are the strongest independent predictors of death after LTx, whereas graft‐related factors appeared to be of minor prognostic importance . These and other predictors of mortality were significantly more prevalent in patients with PMV, which might explain why PMV appeared to be associated with increased mortality.…”

Section: Discussionsupporting

confidence: 90%

“…However, differences between our DLTx cohort and the overall UNOS cohort might exist regarding to the occurrence of airway dehiscence (3% vs. 13%) and the need for RRT (14% vs. 6%) . A comparison with recent UNOS data on 5224 DLTx procedures within a comparable timeframe shows that the 1‐year survival rate in our study (86.0%) falls closer to the upper end of the range previously reported (78.3–84.5% depending on the LAS) .…”

Section: Discussionsupporting

confidence: 62%

“…In the entire LTx cohort, 629 (91.1%) of 690 patients survived to hospital discharge. Thirty (4.3%) patients died within 21 days of LTx, with median survival post‐LTx of 14 days among these patients. The proportion of adults and children dying within 21 days of LTx was 28 (4.3%) of 649 and 2 (4.9%) of 41, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Prolonged Mechanical Ventilation After Lung Transplantation—A Single-Center Study

Hadem

Gottlieb

Seifert

et al. 2016

American Journal of Transplantation

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This single-center study examines the incidence, etiology, and outcomes associated with prolonged mechanical ventilation (PMV), defined as time to definite spontaneous ventilation >21 days after double lung transplantation (LTx). A total of 690 LTx recipients between January 2005 and December 2012 were analyzed. PMV was necessary in 95 (13.8%) patients with decreasing incidence during the observation period (p < 0.001). Independent predictors of PMV were renal replacement therapy (odds ratio [OR]

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 62%

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Prolonged Mechanical Ventilation After Lung Transplantation—A Single-Center Study

Hadem

Gottlieb

Seifert

et al. 2016

American Journal of Transplantation

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“…The reported median survival for lung transplantation is 5.8 years, and previous studies have reported a long‐term survival rate of 17.3% . The 2018 International Society of Heart and Lung Transplantation (ISHLT) annual report described 10‐year survival of approximately 35% for double lung transplants and 20% for single lung transplants …”

Section: Discussionmentioning

confidence: 99%

Long term survival after lung transplantation: A single center experience

et al. 2019

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Background: There are approximately 2000 lung transplants performed across the United States annually. There is limited data to identify factors predictive of longterm survival. Objective: We evaluated 10-year survivors after lung transplant to determine predictors of long-term survival. Methods: Data were collected from the United Network for Organ Sharing registry database from a single institution. Inclusion criteria were: patients who received a lung transplant between 1989 and 2005. Descriptive statistics were calculated, and survival outcomes were analyzed using the Kaplan-Meier method.

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“…Patients with a high lung allocation score and those requiring ECLS as a bridge to transplant both appear to have better survival after DLT. 54 However, there is variability among centers regarding the use of single or DLT, particularly for patients with chronic obstructive pulmonary disease and interstitial lung disease.…”

Section: Single Versus Bilateral Lung Transplantationmentioning

confidence: 99%

National Heart, Lung, and Blood Institute and American Association for Thoracic Surgery Workshop Report: Identifying collaborative clinical research priorities in lung transplantation

Mulligan

Weill²,

Davis

et al. 2018

The Journal of Thoracic and Cardiovascular Surgery

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In 2016, more than 2300 lung transplants were performed in the United States, and approximately 2700 candidates were added to the wait-list. 1 Clinical outcomes after lung transplantation lag behind those achieved with transplantation of other solid organs, with average 5-year survival of 55%. 1 Despite this, lung transplantation is a relatively understudied area of clinical research, and few prospective randomized trials are conducted in lung transplantation. In June 2017, the National Heart, Lung, and Blood Institute (NHLBI) and American Association for Thoracic Surgery (AATS) co-sponsored a workshop designed to bring participants together to summarize the current state of the science in adult lung transplantation, identify knowledge gaps, and determine priorities in clinical lung transplant research that could be addressed in the near future. Workshop topics were initially drafted by the AATS with input from the International Society for Heart and Lung Transplantation (ISHLT), and then finalized by the NHLBI and AATS leadership. Workshop participants included leaders in lung transplantation with specific expertise in thoracic surgery, pulmonary medicine, and bioethics. Although all present acknowledged that chronic lung allograft From the

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Double Lung Transplants Have Significantly Improved Survival Compared With Single Lung Transplants in High Lung Allocation Score Patients

Cited by 23 publications

References 5 publications

Prolonged Mechanical Ventilation After Lung Transplantation—A Single-Center Study

Prolonged Mechanical Ventilation After Lung Transplantation—A Single-Center Study

Long term survival after lung transplantation: A single center experience

National Heart, Lung, and Blood Institute and American Association for Thoracic Surgery Workshop Report: Identifying collaborative clinical research priorities in lung transplantation

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