Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndromes are associated with complex karyotype, monosomal karyotype, <i>TP53</i> deletion, and <i>TP53</i> mutations

Wang, Nan; Liu, Yuan; Yu, Jie; Fan, Ke-Ke; Jin, Hongshi; Lv, Chao; Wang, Lili; Yu, Li

doi:10.1080/10428194.2021.1919663

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…In AML evolution, the eccDNAs also increased with the evolution from HSC to blast, except for LSC. A recent study revealed that AML patients with double minutes (DMs, a kind of ecDNA) presented an extremely poor prognosis [ 14 ]. Approximately 30% of the ecDNA were paired with DMs [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, we speculated that these genes in eccDNA of AML might accelerate the AML progression through the effects of poor prognostic factors, including complex karyotypes, monosomal karyotypes, TP53 deletion, and TP53 mutations. These studies also reported DMs in myeloid neoplasms commonly harbored MYC , KMT2A , or MLL gene amplification [ 13 , 14 ]. Whether the oncogene amplifications of eccDNAs occurred in myeloid tumors still needs further exploration.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study indicated that eccDNA amplification did not occur in blood or normal tissue [ 10 ]. Some other studies have confirmed that double minutes (DMs, a kind of ecDNA) in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are associated with micronuclei, MYC or MLL amplification, complex karyotype, monosomal karyotype, TP53 deletion, and TP53 mutations [ 13 , 14 ]. Though there are some progress in the study of eccDNA in hematological malignancies, the landscape of eccDNA of AML and normal hematopoiesis have not yet to be fully clarified.…”

Section: Introductionmentioning

confidence: 99%

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The landscape of extrachromosomal circular DNA (eccDNA) in the normal hematopoiesis and leukemia evolution

et al. 2022

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Elevated extrachromosomal circular DNA (eccDNA) has been reported to accelerate tumor pathogenesis. Although the eccDNA profiles of other tumors have been established, the landscape of the eccDNA of acute myeloid leukemia (AML) has not been revealed. Our study first depicted the eccDNA profile of normal hematopoiesis and AML evolution by exploiting the ATAC-seq and RNA-seq data from nine healthy donors and 12 AML patients, which contained a total of 137 cell samples and 96 RNA-seq samples (including 16 blood cell types of the normal hematopoietic and AML hierarchies). We found the number of eccDNAs generally increased with the evolution of normal hematopoiesis and AML. The ecDNAs and ring chromosomes were found to reappear both in normal hematopoiesis and AML cells. Furthermore, we compared the eccDNAs of AML with normal cells. There were almost 300 AML-specific genes, including the known oncogenes NRAS, MCL1, EVI1, GATA2, WT1, and PAK1. And the ecDNA (chr11: 58668376-58826008) occurred in five out of 17 AML evolution-related cells, which was associated with the high expression of the GLYATL1 gene and the high expressed GLYATL1 was a poor prognostic factor. In conclusion, the eccDNA profiles of normal hematopoiesis and AML evolution were depicted and the recurrent eccDNAs we revealed might be utilized in the treatment of AML as biomarkers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The landscape of extrachromosomal circular DNA (eccDNA) in the normal hematopoiesis and leukemia evolution

et al. 2022

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Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistance

Li,

Qian

2024

Clin Exp Med

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Extrachromosomal circular DNA (eccDNA) is a circular form of DNA that exists outside of the chromosome. Although it has only been a few decades since its discovery, in recent years, it has been found to have a close relationship with cancer, which has attracted widespread attention from researchers. Thus far, under the persistent research of researchers from all over the world, eccDNA has been found to play an important role in a variety of tumors, including breast cancer, lung cancer, ovarian cancer, etc. Herein, we review the sources of eccDNA, classifications, and the mechanisms responsible for their biogenesis. In addition, we introduce the relationship between eccDNA and various cancers and the role of eccDNA in the generation and evolution of cancer. Finally, we summarize the research significance and importance of eccDNA in cancer, and highlight new prospects for the application of eccDNA in the future detection and treatment of cancer.

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Histone methyltransferase KMT2A: Developmental regulation to oncogenic transformation

Ogino,

Dou

2024

Journal of Biological Chemistry

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Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndromes are associated with complex karyotype, monosomal karyotype, TP53 deletion, and TP53 mutations

Cited by 4 publications

References 34 publications

The landscape of extrachromosomal circular DNA (eccDNA) in the normal hematopoiesis and leukemia evolution

The landscape of extrachromosomal circular DNA (eccDNA) in the normal hematopoiesis and leukemia evolution

Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistance

Histone methyltransferase KMT2A: Developmental regulation to oncogenic transformation

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