Double primary hepatic cancer (hepatocellular carcinoma and intrahepatic cholangiocarcinoma) in a single patient: A case report

Abstract

Abstract. Double primary hepatic cancer, consisting of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) located separately within a single liver simultaneously, is extremely rare. The present study reports a case of double hepatic nodules, in which HCC and ICC occurred simultaneously in the right hepatic lobe. The 47-year-old male patient, who was a carrier of hepatitis B virus, was admitted to our hospital for physical examination, which revealed two liver masses. The results of initial laboratory tests, including liver function tests, were within normal limits, with the exception of mildly elevated aspartate aminotransferase and alanine aminotransferase, and decreased albumin levels. α-fetoprotein was in the normal range, while carbohydrate antigen 19-9 was marginally elevated. Abdominal ultrasonography and enhanced computed tomography revealed two tumors located in segments (S) VI and VII of the liver, respectively, with malignant behavior. Examination of the two masses following resection of S VI and VII confirmed a diagnosis of combined HCC and ICC. After 8 months of follow-up, no signs of recurrence have been observed with chemical therapy.

An unresectable and metastatic intrahepatic cholangiocarcinoma with EML4-ALK rearrangement achieving partial response after first-line treatment with ensartinib: a case report

“…The incidence of synchronous double primary ICC and another cancer is too low to have sufficient data. Several cases of double primary hepatic cancers with hepatocellular carcinoma and ICC were reported ( 17 – 19 ), but only one case report described double primary cancers with ICC and lung squamous cell carcinoma ( 20 ). Considering the rarity of double primary cancers, we suspected that pulmonary lesions were more likely to be metastatic, but we could not obtain the lung tissue, which is a limitation of this case report.…”

Intrahepatic cholangiocarcinoma with aberrant hepatic artery presenting as hepatic abscess: a case report

“…18 In this case, pleural empyema occured after transdiaphragmatic rupture of HA, which led to patient's respiratory failure and death 22 days following surgery. 16,17 Cases of patients with ICC present as HA have been reported in the past decades, but pitfalls in the diagnosis are still existing. ICC is highly malignant, Li et al reported four cases of ICC that presented as HA, all of them died with 1 year.…”