Purpose:To retrospectively evaluate the performance of consensus double reading compared with single reading at baseline screening of a lung cancer computed tomography (CT) screening trial.
Materials and Methods:The study was approved by the Dutch Minister of Health and ethical committees. Written informed consent was obtained from all participants. The benefi t of consensus double reading was expressed by the percentage change in cancer detection rate, recall rate, number of additional nodules detected, and change in sensitivity and specifi city in 7557 participants. The reference standard was a retrospective analysis of the serial CT scans performed in participants diagnosed with lung cancer during a 2-year period after baseline. Semiautomated volumetric software was used for nodule evaluation. McNemar tests were performed to test statistical signifi cance. In addition, sensitivity, specifi city, positive predictive value (PPV), and negative predictive value (NPV) were calculated and 95% confi dence intervals (CIs) constructed.
Results:Seventy-four cases of lung cancer were qualifi ed as detectable at baseline. Compared with single reading, consensus double reading did not increase the cancer detection rate (2.7%; 95% CI: 2 1.0%, 6.4%; P = .50) or change the recall rate (20.6% vs 20.8%, P = .
Conclusion:There is no statistically signifi cant benefi t for consensus double reading at baseline screening for lung cancer with the use of a nodule management strategy based solely on semiautomated volumetry.