Double Resection for Patients with Pancreatic Cancer and a Second Primary Renal Cell Cancer

Abstract

Background: Reports of synchronous or metachronous double kidney-pancreas cancers are very rare. Methods: We present 2 patients with renal cell carcinoma and synchronous (1 patient) or metachronous (1 patient) primary pancreatic ductal adenocarcinoma. The patients underwent resection for both cancer types with a worthwhile outcome. Results: The appearance of different primaries in an individual may indicate a genetic predisposition to different neoplasms. The study of double primary cancers is important because it might provide understanding of a shared genetic basis of different solid tumors. Conclusions: The association between these two cancers demands more detailed epidemiological and molecular investigation. From a clinical viewpoint a resectional policy is recommended.

Synchronous Primary Renal Cell Carcinoma and Pancreatic Ductal Adenocarcinoma: Case Report and Literature Review

“…Multiple primary cancers (MPC) in the same patient are rare, but synchronous MPC are exceptional [ 1 , 2 ]. Most synchronous tumors involve both the gastrointestinal and the genitourinary tract, followed by the breast and gastrointestinal tract or the breast and genitourinary tract [ 3 ].…”

“…However, there has been only infrequent reporting of synchronous or metachronous tumors of the kidney and the pancreas [ 1 , 2 , 3 , 4 ]. In 1969, Sasaki et al [ 5 ] reported the first case of an association between renal and pancreatic cancer.…”

“…Multiple primary malignancies are uncommon (1–3% of all cancers), but synchronous multiple primary tumors are extremely rare, and synchronous primary tumors involving the kidney and pancreas are exceptional and poorly documented [ 1 , 2 ]. Indeed, there are only a few reports of this situation in the English literature.…”

Renal tumors and second primary pancreatic tumors: a relationship with clinical impact?

“…Since then, only a few more case reports have been published of this coincidence with the largest group including 6 patients. Alexakis et al presented 2 patients with RCC and synchronous primary PDAC [8]. …”

“…Second malignancies reported to be associated with renal cell carcinoma (RCC) include Non-Hodgkin’s lymphoma, multiple myeloma, chronic lymphatic leukaemia, melanoma and cancers of the bladder, prostate, breast, rectum, and lung with an incidence that varies from 5 to 27% [6,7]. There has only been infrequent reporting of synchronous or metachronous tumors of the pancreas and the kidney [5,7,8]. …”