Double-shell gold nanoparticle-based DNA-carriers with poly-l-lysine binding surface

Stobiecka, Magdalena; Hepel, Maria

doi:10.1016/j.biomaterials.2010.12.064

Cited by 85 publications

(60 citation statements)

References 42 publications

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“…GNPs are also known to be effective delivery agents for small interfering RNA and DNA-based enzymes [17]. The highly enhanced and tunable optical properties of gold nanorods in both visible and near infrared regions make them suitable for gene delivery, biosensing [3] and for X-ray CT imaging [18]. DNA vaccines have been effectively delivered through GNPs [19].…”

Section: Applications Of Gold Nanoparticles In the Field Of Medicinementioning

confidence: 99%

Review of Applications and Environmental Fate of Gold Nanoparticles

Palaniappan¹

2018

International Conference of Recent Trends in Environmental Science and Engineering

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-The unique properties of nanomaterials do enable them to contribute significantly to environmental protection; however at the same time, they also have a significant negative impact on the environment as well as on living organisms. Among the existing nanomaterials, gold nanoparticle (GNP) is quickly gaining grounds due to its wide ranging uses in the field of medicine, especially radiation therapy and targeted drug delivery. Apparently, the increased production, application and disposal of GNPs have led to an increased release of nanogold into the environment and there are very few studies that bring out the implications of such release. This study aims to review various applications of GNPs and their fate in the environment.

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Section: Applications Of Gold Nanoparticles In the Field Of Medicinementioning

confidence: 99%

Review of Applications and Environmental Fate of Gold Nanoparticles

Palaniappan¹

2018

International Conference of Recent Trends in Environmental Science and Engineering

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“…Gold nanoparticles exhibit different shapes such as spherical, sub-octahedral, octahedral, decahedral, icosahedral multiple twined, multiple twined, irregular shape, tetrahedral, nanotriangles, nanoprisms, hexagonal platelets, and nanorods, which are shown in Figure 2. Among the various shapes triangular-shaped nanoparticles show attractive optical properties compared with the spherical-shaped nanoparticles [30,58,[63][64][65][66][67][68][69][70][71][72]. …”

Section: Metal Nanoparticle (Gold Nanoparticle)mentioning

confidence: 99%

Medicated Nanoparticle for Gene Delivery

Prabu¹,

KuppusamiSuriyaprakash²,

Rathinasabapathy³

2017

Advanced Technology for Delivering Therapeutics

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“…[1][2][3][4][5][6][7] Nanocarrier-based drug delivery systems afford key advantages to the conventional treatment modes: controlled release and targeted delivery. The ability to keep the drug inactive, while in transit, and release it in its active form, under the appropriate physiochemical conditions, [6][7][8][9][10] mitigates the collateral damage to healthy tissue, which in conventional approaches is an inherent consequence that goes largely unchecked.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, through multifunctionalization, nanocarriers can contain not only anticancer payloads but also ligands that preferentially bind to surface receptor proteins of cancer cells and mediate endocytosis of the nanocarrier. These key advantages have recently attracted considerable interest 7764 santiago et al and led to the development of various nanocarrier-based systems, including micellar, [11][12][13] liposome, 14,15 polymer, [16][17][18] noble metal, 4,5,19 and other 2,20 nanocarriers. Here, we present an investigation into a nanocarrier-based targeted drug delivery system for the anticancer drug gemcitabine (GEM) administration.…”

Section: Introductionmentioning

confidence: 99%

Surface-enhanced Raman scattering investigation of targeted delivery and controlled release of gemcitabine

Santiago¹,

DeVaux

Kurzątkowska³

et al. 2017

IJN

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Advanced and metastatic cancer forms are extremely difficult to treat and require high doses of chemotherapeutics, inadvertently affecting also healthy cells. As a result, the observed survival rates are very low. For instance, gemcitabine (GEM), one of the most effective chemotherapeutic drugs used for the treatment of breast and pancreatic cancers, sees only a 20% efficacy in penetrating cancer tissue, resulting in <5% survival rate in pancreatic cancer. Here, we present a method for delivering the drug that offers mitigation of side effects, as well as a targeted delivery and controlled release of the drug, improving its overall efficacy. By modifying the surface of gold nanoparticles (AuNPs) with covalently bonded thiol linkers, we have immobilized GEM on the nanoparticle (NP) through a pH-sensitive amide bond. This bond prevents the drug from being metabolized or acting on tissue at physiological pH 7.4, but breaks, releasing the drug at acidic pH, characteristic of cancer cells. Further functionalization of the NP with folic acid and/or transferrin (TF) offers a targeted delivery, as cancer cells overexpress folate and TF receptors, which can mediate the endocytosis of the NP carrying the drug. Thus, through the modification of AuNPs, we have been able to produce a nanocarrier containing GEM and folate/TF ligands, which is capable of targeted controlled-release delivery of the drug, reducing the side effects of the drug and increasing its efficacy. Here, we demonstrate the pH-dependent GEM release, using an ultrasensitive surface-enhanced Raman scattering spectroscopy to monitor the GEM loading onto the nanocarrier and follow its stimulated release. Further in vitro studies with model triple-negative breast cancer cell line MDA-MB-231 have corroborated the utility of the proposed nanocarrier method allowing the administration of high drug doses to targeted cancer cells.

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Double-shell gold nanoparticle-based DNA-carriers with poly-l-lysine binding surface

Cited by 85 publications

References 42 publications

Review of Applications and Environmental Fate of Gold Nanoparticles

Review of Applications and Environmental Fate of Gold Nanoparticles

Medicated Nanoparticle for Gene Delivery

Surface-enhanced Raman scattering investigation of targeted delivery and controlled release of gemcitabine

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