Double-stranded RNA adenosine deaminase activity during measles virus infection

Horikami, Sandra M.; Moyer, Sue A.

doi:10.1016/0168-1702(94)00103-j

Cited by 14 publications

(10 citation statements)

References 27 publications

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“…Viperin, another interferon-inducible protein, has been shown to have anti-viral activity against HCV and influenza virus (Helbig et al, 2005; Hinson and Cresswell, 2009; Jiang et al, 2008). As mentioned earlier, ADAR1 has been shown to have antiviral activity against a variety of RNA viruses (Horikami and Moyer, 1995; Patterson and Samuel, 1995; Polson, Bass, and Casey, 1996; Sato, Wong, and Lazinski, 2001). The hydrolytic deamination of adenosine to inosine in completely or partially double-stranded RNA by ADAR1 affects pre mRNA splicing, incorporates incorrect amino acid during translation, and decreases the binding of RNA to protein.…”

Section: Discussionmentioning

confidence: 78%

“…ADAR1 inhibits replication of hepatitis delta virus by editing of adenosine to inosine in pre-mRNA of hepatitis delta virus which eventually affects splicing of untranslated regions (Patterson and Samuel, 1995; Polson, Bass, and Casey, 1996; Sato, Wong, and Lazinski, 2001). ADAR1 was also known to edit double-stranded RNA found in the measles virus, which inhibited virus assembly and release from cells, leading to a persistent infection and development of fatal neuropathic measles infection (Horikami and Moyer, 1995). Taylor, et al (2005) showed that ADAR1-induced viral RNA editing inhibited Hepatitis C viral replication (Taylor et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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ADAR1 is a novel multi targeted anti-HIV-1 cellular protein

et al. 2012

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We examined the antiviral activity of ADAR1 against HIV-1. Our results indicated that ADAR1 in a transfection system inhibited production of viral proteins and infectious HIV-1 in various cell lines including 293T, HeLa, Jurkat T and primary CD4+ T cells, and was active against a number of X4 and R5 HIV-1 of different clades. Further analysis showed that ADAR1 inhibited viral protein synthesis without any effect on viral RNA synthesis. Mutational analysis showed that ADAR1 introduced most of the A-to-G mutations in the rev RNA, in the region of RNA encoding for Rev Response Element (RRE) binding domain and in env RNA. These mutations inhibited the binding of rev to the RRE and inhibited transport of primary transcripts like gag, pol and env from nucleus to cytoplasm resulting in inhibition of viral protein synthesis without any effect on viral RNA synthesis. Furthermore, ADAR1 induced mutations in the env gene inhibited viral infectivity.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

ADAR1 is a novel multi targeted anti-HIV-1 cellular protein

et al. 2012

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“…The tRNA:adenosine 34 deaminase likely belongs to the family of deaminases (the so-called editing enzymes or dsRNA-specific editases) that act on doublestranded RNA (Hough & Bass, 1994;O'Connell & Keller, 1994;Kim et al, 1994), on intron-containing precursor mRNA (Melcher et al, 1995(Melcher et al, , 1996Rueter et al, 1995;Yang et al, 1995), and/or on RNA virus (Rataul et al, 1992;Ecker et al, 1995;Horikami & Moyer, 1995;Polson et al, 1996). It may also have much in common with another family of deaminases that act on the amino group in the C-4 position of free cytidine (Betts et al, 1994), 2'deoxy-CMP (McIntosh & Haynes, 1986), or specific cytidine bases in polymeric mRNA (e.g.…”

Section: Mechanism Of Inosine 34 Formation In Trnamentioning

confidence: 98%

Mechanism, Specificity and General Properties of the Yeast Enzyme Catalysing the Formation of Inosine 34 in the Anticodon of Transfer RNA

Auxilien

Crain

Trewyn

et al. 1996

Journal of Molecular Biology

103

124

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“…The recovery of hyper-edited genomes of Schwarz strain measles virus from IFN sensitive MRC5 cells included multiple A-to-G transitions, whereas genomes amplified from MV infected Vero cells showed typical quasispecies variation of an RNA virus (Suspène et al, 2008). While one study suggested that modification of MV RNAs by ADAR must occur at a very low level if at all based on levels of ADAR activity in cells (Horikami and Moyer, 1995), direct evidence consistent with a functional role of the IFN inducible ADAR1 deaminase as a restriction factor for controlling measles virus infection was provided by the study of mouse embryo fibroblasts (MEFs) stably expressing the SLAM receptor for MV (Ward et al, 2010). MEFs genetically null for the p150 form of ADAR1 displayed extensive syncytium formation and virus-induced cytotoxicity following infection with Edmonston MV strain, and produced infectious yields ~3 to 4 log 10 higher at early times after infection, compared to wild-type MEFs (Ward et al, 2010).…”

Section: Effects Of Adars and A-to-i Editing On Virus-host Interactionsmentioning

confidence: 99%

Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral

2011

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A-to-I RNA editing, the deamination of adenosine (A) to inosine (I) that occurs in regions of RNA with double-stranded character, is catalyzed by a family of Adenosine Deaminases Acting on RNA (ADARs). In mammals there are three ADAR genes. Two encode proteins that possess demonstrated deaminase activity: ADAR1, which is interferon-inducible, and ADAR2 which is constitutively expressed. ADAR3, by contrast, has not yet been shown to bean active enzyme. The specificity of the ADAR1 and ADAR2 deaminases ranges from highly site-selective to non-selective, dependent on the duplex structure of the substrate RNA. A-to-I editing is a form of nucleotide substitution editing, because I is decoded as guanosine (G) instead of A by ribosomes during translation and by polymerases during RNA-dependent RNA replication. Additionally, A-to-I editing can alter RNA structure stability as I:U mismatches are less stable than A:U base pairs. Both viral and cellular RNAs are edited by ADARs. A-to-I editing is of broad physiologic significance. Among the outcomes of A-to-I editing are biochemical changes that affect how viruses interact with their hosts, changes that can lead to either enhanced or reduced virus growth and persistence dependent upon the specific virus.

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Double-stranded RNA adenosine deaminase activity during measles virus infection

Cited by 14 publications

References 27 publications

ADAR1 is a novel multi targeted anti-HIV-1 cellular protein

ADAR1 is a novel multi targeted anti-HIV-1 cellular protein

Mechanism, Specificity and General Properties of the Yeast Enzyme Catalysing the Formation of Inosine 34 in the Anticodon of Transfer RNA

Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral

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