Double-valve infective endocarditis: clinical features and prognostic impact—a retrospective study in a surgical centre

Scheggi, Valentina; Pace, Stefano Del; Ceschia, Nicole; Vanni, Francesco; Merilli, Irene; Zoppetti, Nicola; Alterini, Bruno; Marchionni, Niccolò; Stefàno, Pier Luigi

doi:10.1007/s00380-021-01980-2

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Streptococcus viridans and Staphylococcus aureus collectively account for the etiology of 80% of native valves IE, while 10% are considered culture-negative [ 3 ]. Fewer studies analyzed patients with DVIE [ 9 , 10 ], but in a recent one including 1340 patients with acute left-sided native valve IE, 19% of patients had bivalvular involvement. The etiology was predominantly represented by Streptococcus spp.…”

Section: Discussionmentioning

confidence: 99%

“…The involvement of two or more cardiac valves is less frequently described [ 3 ], and it may predominantly affect the mitral and aortic valves [ 5 ]. When DVIE occurs, it results in more severe and extensive cardiac lesions, extracardiac complications [ 9 ], and a greater risk of mortality [ 5 ]. Prosthetic valve endocarditis (PVE) is the most severe form of IE, accounting for approximately 20% of cases [ 13 ], with bioprosthetic valves at higher risk [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Native and Prosthetic Simultaneously Double Valve Infective Endocarditis with Enterococcus faecalis—Case-Based Review

Haliga

Șorodoc

Morăraşu

et al. 2023

JPM

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Infective endocarditis is a severe infective heart disease, commonly involving native or prosthetic valves. It frequently presents with univalvular involvement and simultaneous double valve or multivalvular involvement is rarely described. The third leading cause of infective endocarditis worldwide is Enterococcus faecalis, which is associated with high mortality rates despite important advances in antimicrobial therapy. It develops secondary to enterococcal bacteremia, with its origin from the gastrointestinal or genitourinary tract and predominantly affecting the elderly population with multiple comorbidities. Clinical presentation is usually less typical, and the treatment is challenging. It can be marked by antibiotic resistance, side effects, and subsequent complications. Surgical treatment can be considered if deemed appropriate. To the best of our knowledge, we present the first case-based narrative review of Enterococcus faecalis double valve endocarditis involving both the aortic native and prosthetic mitral valve, highlighting the clinical characteristics, treatment, and complications of this condition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Native and Prosthetic Simultaneously Double Valve Infective Endocarditis with Enterococcus faecalis—Case-Based Review

Haliga

Șorodoc

Morăraşu

et al. 2023

JPM

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Bivalvular Endocarditis Due to Polymicrobial Coinfection with Enterococcus faecalis and Coxiella burnetii: A Case Report and Review of the Literature

Abu-Ahmad,

Bahouth,

Hershman-Sarafov

et al. 2024

Medicina

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Polymicrobial endocarditis is uncommon, and polymicrobial endocarditis in combination with Coxiella burnetii is very rare. We herein describe an extremely rare case of polymicrobial bivalvular endocarditis due to coinfection with Enterococcus faecalis and Coxiella burnetii in a 62-year-old male patient, and extensively review the relevant medical literature. To the best of our knowledge, only three similar cases have been previously reported. Q fever is a worldwide endemic bacterial zoonosis, but it and its most common chronic complication, endocarditis, are still underestimated and underdiagnosed worldwide. This situation reflects the paucity of reported cases of polymicrobial endocarditis in combination with Coxiella burnetii. Clinical presentation of Q fever endocarditis is highly nonspecific, and diagnosis may be delayed or missed, leading to severe and potentially fatal disease. Our case and the previously reported similar cases emphasize the need for further evaluation of infective endocarditis due to Coxiella burnetii, in all cases of culture-negative endocarditis, and in prolonged oligo-symptomatic inflammatory syndrome, particularly in the presence of valvular heart disease. This approach should be applied even when typical pathogens are isolated, especially in endemic areas of Q fever, and with atypical presentation.

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Double-valve infective endocarditis: clinical features and prognostic impact—a retrospective study in a surgical centre

Cited by 2 publications

References 13 publications

Native and Prosthetic Simultaneously Double Valve Infective Endocarditis with Enterococcus faecalis—Case-Based Review

Native and Prosthetic Simultaneously Double Valve Infective Endocarditis with Enterococcus faecalis—Case-Based Review

Bivalvular Endocarditis Due to Polymicrobial Coinfection with Enterococcus faecalis and Coxiella burnetii: A Case Report and Review of the Literature

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