Double versus single intrauterine insemination (IUI) in stimulated cycles for subfertile couples

Abstract

Double versus single intrauterine insemination (IUI) in stimulated cycles for subfertile couples.

Correlation between the times of IUI and pregnancy outcome: a systematic review and meta-analysis with trial sequential analysis of cohort study

“…Considering that increasing the times of insemination inevitably has an impact on the internal environment of the uterus and that only a few studies in the included literature reported this, the results may be biased. But the results are consistent with the results of the Cochrane Collaboration [50] , that is, increasing the times of insemination per cycle does not increase the incidence of biochemical pregnancy, miscarriage, or ectopic pregnancy.…”

“…2003 update, which included a study with a larger sample size [41] , shifted to consider the advantages of double insemination. In the latest version (2021), the evaluators then concluded that double insemination did not improve cycle pregnancy rates compared to single insemination [42] . Other researchers have also conducted related studies: an earlier Meta-analysis [43] clearly a rmed the positive aspects of double insemination.…”

“…Although Meta-analysis of RCT studies have been conducted by the Cochrane Collaboration and other researchers on this issue, the analysis of the results is affected by the low quality of included studies [50] and the large differences in Controlled ovarian hyper-stimulation (COH) cycles and timing of insemination [45] . This, together with the fact that RCT studies are more di cult to conduct with large samples and strict inclusion and exclusion criteria, can lead to some differences in the representativeness and external veracity of the results.…”

Intrauterine Insemination After Human Chorionic Gonadotropin Trigger or Luteinizing Hormone Surge

“…It is unclear if multiple IUIs per cycle improve pregnancy rates. 34,37,46 In terms of interventions, dosing of medication, for both oral ovarian stimulation medication and dose of hCG trigger shot administration, varied. [47][48][49][50] No significant differences in pregnancy rates were observed between the intervention groups in natural or ovarian stimulation cycles.…”