Double μ2-(phenoxido)-bridged dinuclear and polynuclear nickel(II) complexes: Magnetic properties and DNA/protein interaction

Abstract

One dinuclear and one 1D polymeric nickel(II) complex, namely {[Ni2(HL)2(pa)2(H2O)2]•DMF} (1) and {[Ni2(HL)2(ppda)(H2O)2]•DMF•H2O}n (2) (H2L = (E)-2-((1-hydroxybutan-2ylimino)methyl)phenol, pa = 3-phenylacrylate, ppda = p-phenylenediacrylate) have been synthesized and characterized by X-ray single crystal structure determination. Complex 1 is double phenoxo-bridged dinuclear Ni(II) complex, whereas complex 2 is a 1D polynuclear chain where double phenoxo-bridged dinuclear units are connected through bridging ppda ligands. The variable temperature magnetic behavior of the complexes was studied using the Hamiltonian H = −JS1S2, S1 = S2 = SNi and confirms the presence of an overall antiferromagnetic interaction in both complexes. Good agreement between the experimental and simulated curves were found using the parameters: gNi = 2.15, DNi = 4.0 cm−1 and JNi-Ni = −0.60 cm−1 for 1, and gNi = 2.15, DNi = 4.8 cm−1 and JNi-Ni = −3 cm−1 for 2. The interactions of the complexes with CT-DNA were investigated using UV-Vis absorption and fluorescence spectroscopic methods and they show that both the complexes interact with CT-DNA. The intrinsic binding constants values for interaction with CT-DNA are 3.9(±0.10) × 105 and 3.43(±0.09) × 105 M−1 for 1 and 2, respectively. The interactions of the complexes with bovine serum albumins (BSA) and human serum albumins (HSA) were also studied using electronic absorption and fluorescence spectroscopic techniques and the results show that both complexes interact with the serum albumins via a ground state association process.

Weakly antiferromagnetic vanillin and acetate bridged dinuclear Ni(ii) compound exhibiting catecholase-like activity and biological properties

“…The major contribution controlling the magnetic coupling (J Ni-Ni ) in compound 1 is the phenoxide bridge from p-vanillin, which works as a magnetic exchange pathway between the Ni(II) centers. 84,85 From the theoretical and experimental data, the literature discussed in Table S1 Compound 1 showed dose-dependent toxicity toward HepG2 cancer cells, as depicted in Fig. 7a.…”

In Vitro Insight on Antifungal-Specific Potentiality of Ni(II) Complex against Colletotrichum siamense and Fusarium equisetum Phytopathogens

“…To get significant insights about the chemotherapeutic activities of any bioactive molecule, the binding affinity investigation of that molecule with DNA and BSA/HSA is very important, as for almost all the anticancer and antifungal drugs, DNA is the target macromolecule, and serum albumins are the most soluble plasma proteins that have the capability to transport those drugs. , There are mainly three types of interactions that occur with DNA (intercalation, groove binding, and surface interaction) which are altered due to the change in the metal ion or the ligands of metal complexes. − Therefore, in the design of effective metal complexes as drugs, binding affinity investigation of these complexes with DNA and BSA/HSA is very crucial. Hence, before progressing to model experiments, we assessed the potential of our synthesized compound by testing it on commercially available DNA and BSA.…”

Carboxylato‐ and squarato‐bridged dinuclear/tetranuclear Cu(II) complexes: Synthesis, magnetic property, and protein binding studies

“…In addition, polynuclear Cu(II) complexes are important for their intriguing magnetic properties. [ 5 ] For the synthesis of such species, chelating molecules in combination with bridging ligands such as azide, thiocyanate, and various oxo anions are widely used. Chelating ligands block some coordination sites, [ 6 ] whereas in order to understand the basics of molecular magnetism, short bridging ligands are useful for communicating electronic information among the paramagnetic centers.…”