Douchi ameliorates high‐fat diet‐induced hyperlipidaemia by regulation of intestinal microflora in rats

Summary Brown rice‐based foods are thought to be effective in preventing obesity. In this study, the effect of whole‐grain flat rice noodles (WFRN) on lipid metabolism as well as their relationship with gut microbiota was investigated in mice fed a high‐fat diet (HFD). The results indicated that WFRN reduced the degree of obesity, the lipid levels in the liver and serum, and the risk of liver inflammation. Moreover, WFRN significantly increased the contents of total short‐chain fatty acids (SCFAs) (from 162.06 ± 29.79 to 272.97 ± 59.26 μg mL−1; P < 0.05) and reshaped the composition of gut microbiota in mice cecum. As the beneficial bacteria with boosted abundance, higher Coriobacteriaceae_UCG‐002 was negatively related to the lipid levels in the liver and serum, and positively correlated with the content of hexanoic acid. On the contrary, the lower abundance of harmful bacteria Staphylococcus was positively correlated to body fat and inversely related to isovaleric acid, and Helicobacter was positively associated with higher serum LDL‐C and lower hexanoic acid. This study suggested that WFRN played a positive role in ameliorating lipid accumulation and inflammation caused by obesity, and this effect was closely associated with the regulation of gut microbiota and SCFAs.

Section: Resultsmentioning

confidence: 99%

Whole‐grain flat rice noodles improve lipid metabolism in high‐fat‐diet‐fed mice in association with gut microbiota

Luo

Yuan

et al. 2023

“…On the other hand, the health‐beneficial effects of fermentation metabolites of fibre to enhance overall well‐being and digestive health has been shown (An et al ., 2022; Ratanpaul et al ., 2023). The current emphasis on ultra‐processed foods and reduced fibre and vegetable intake in diets is linked to a rise in chronic metabolic diseases.…”

Section: Introductionmentioning

confidence: 99%

Bibliometric analysis of the impact of ultra‐processed foods on the gut microbiota

Baspakova,

Bazargaliyev,

Kaliyev

et al. 2024

SummaryThe escalating demand for ultra‐processed foods poses a growing concern due to its potential adverse effects on human health. This study conducts a comprehensive bibliometric analysis of research and review articles investigating the intricate relationship between ultra‐processed foods and the gut microbiota. Employing rigorous search strategies across Scopus and Web of Science databases, we identified 211 English‐language articles. Utilizing Biblioshiny and R‐tool Bibliometrix, we analysed publication and citation trends, prominent contributors, collaborative networks, and influential journals. Our investigation reveals a consistent upward trajectory in both publications and citations over the past 42 years. Notably, the articles by Chassaing et al. (2015) and Thomas et al. (2011) stand out with the highest citation counts, highlighting their impact in research and review domains. The United States emerges as a key player, leading in both citations and productivity. "Nutrients" emerges as a dominant journal in disseminating knowledge in this field. Importantly, our analysis extends beyond bibliometrics to glean insights into the actual impact of ultra‐processed foods on the gut microbiota. Synthesizing findings from the reviewed articles, we observe a nuanced relationship between ultra‐processed food consumption and alterations in the gut microbiota composition. While the specific "dry" impact remains a focal point, our results underscore the need for targeted research to elucidate the molecular and functional implications of these dietary patterns on gut microbial communities. This 42‐year bibliometric journey underscores the increasing awareness and concern surrounding the impact of ultra‐processed foods on the gut microbiota. The rising trend in publications and citations, coupled with our nuanced insights, emphasizes the continued significance of this field. Researchers, policymakers, and health professionals will find our study valuable for understanding the evolving landscape and addressing the broader implications of modern dietary trends on human health.

“…Obesity is currently managed with the use of lifestyle modifications and pharmacotherapy (Singh et al ., 2020). Fewer research is focused on the application food bioactive ingredients in the treatment and prevention of obesity (Liang et al ., 2021; An et al ., 2022). Among several anti‐obesity mechanisms, research has largely been focused on treating or preventing obesity through the inhibition of adipogenesis (Jang et al ., 2016; Podsędek et al ., 2020; Guillemet et al ., 2022).…”

Section: Introductionmentioning

confidence: 99%

Impact of phenolic extracts and potassium hydroxycitrate of Hibiscus sabdariffa on adipogenesis: a cellular study

Singh

Thrimawithana

Shukla

et al. 2023

Adipogenesis is a complex physiological process involving the formation of adipocytes and accumulation as adipose tissues. It is one of the contributors for the development of obesity. This study assessed the potential of phenolic extracts and potassium hydroxycitrate, obtained from Hibiscus sabdariffa, to inhibit adipogenesis. The phenolic extracts were obtained using organic solvents (methanol, ethanol and ethyl acetate) and water individually. Human adipose-derived stem cells (hADSCs) were selected to study the impact of these extracts on adipogenesis. Results showed that phenolic extracts were able to reduce lipid accumulation by about 95% in hADSCs, while potassium hydroxycitrate did not show any reduction. All the phenolic extracts downregulated the gene expression of two key adipogenic markers (PPAR-γ and aP2). Ethanol extracts exhibited the highest downregulation of PPAR-γ and aP2 by 3 and 10 times, respectively. There was no improvement in the anti-adipogenic potential when the phenolic extract was combined with potassium hydroxycitrate confirming that phenolic compounds were responsible for the inhibition of adipogenesis. These results indicate that phenolic extracts from H. sabdariffa have potential to regulate the expression of adipogenic genes and restrict the lipid accumulation in mature adipocytes. Thus, phenolic extracts can be used in formulations intended to manage obesity.