Down-regulated serum microRNA-101 is associated with aggressive progression and poor prognosis of cervical cancer

Jiang, Wei; Pan, J.; Deng, Ying; Liang, Meirong; Yao, Li Hua

doi:10.3802/jgo.2017.28.e75

Cited by 28 publications

(19 citation statements)

References 33 publications

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“…Lin et al reported miR-101 upregulation was mostly correlated to significant decreased cellular motility of cervical cancer [ 32 ]. Also, miR-101 downregulation was found in patients with cervical lymph node metastasis and associated with shortened survival time [ 33 ]. In bladder transitional cell carcinoma, low miR-101 expression predicted worse prognosis of patients, and had strong association with the presence of advanced tumor stage and lymph node metastasis [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic implications of serum miR-101 in osteosarcoma

Yao

Liang

et al. 2018

CBM

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Blood-circulating microRNAs (miRNAs) have been reported to be used as potential biomarkers in various cancers. MiR-101 has been found to act as a tumor suppressor in many tumor types, but little is known for osteosarcoma. The purpose of this study was to investigate miR-101 expression in osteosarcoma patients and assess its correlation with clinical features and prognosis. Serum samples from 152 osteosarcoma patients and 70 healthy controls were detected using quantitative reverse-transcription polymerase chain reaction (qRT-PCR). The data showed that miR-101 expression levels were remarkably underexpressed in serum samples from osteosarcoma patients compared to controls, and the post-treatment serum miR-101 expression was significantly higher than that in the pre-treatment expression. Low serum miR-101 expression was positively associated with advanced clinical stage and distant metastasis. Receiver operating characteristic (ROC) curve analysis showed that serum miR-101 could serve as a useful marker for osteosarcoma diagnosis, with a high sensitivity and specificity. Moreover, patients with high miR-101 expression had longer overall survival and recurrence free survival than those with low miR-101 expression. In addition, both univariate and multivariate analyses showed that serum miR-101 downregulation was associated with shorter overall survival and recurrence free survival. Our present results implicated serum miR-101 might be a useful biomarker for the clinical diagnosis and prognosis of osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic implications of serum miR-101 in osteosarcoma

Yao

Liang

et al. 2018

CBM

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“…For example, miR-155 upregulation was an independent prognostic indicator of overall survival for cervical cancer [ 11 ]. Downregulated serum level of miR-101 was an independent predictor of the unfavorable prognosis of cervical cancer [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Preserved miR-361-3p Expression Is an Independent Prognostic Indicator of Favorable Survival in Cervical Cancer

et al. 2018

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In this study, we aimed to assess the independent prognostic value of miR-361-3p in terms of overall survival (OS) and recurrence-free survival (RFS) in cervical cancer, as well as its possible regulative network. A retrospective analysis was performed by using data from the Cancer Genome Atlas-Cervical Cancer (TCGA-CESC). Results showed that decreased miR-361-3p expression was associated with lymphovascular invasion and poor responses to primary therapy. The patients with recurrence and the deceased cases had substantially lower miR-361-3p expression compared to their respective controls. By generating Kaplan-Meier curves of OS and RFS, we found that high miR-361-3p expression was associated with better survival outcome. More importantly, univariate and multivariate analysis confirmed that high miR-361-3p expression was an independent indicator of favorable OS (HR: 0.377, 95% CI: 0.233–0.608, p < 0.001) and RFS (HR: 0.398, 95% CI: 0.192–0.825, p = 0.013). By performing bioinformatic analysis, we identified 24 genes that were negatively correlated with miR-361-3p expression. Among the potential targeting genes, SOST, MTA1, TFRC, and YAP1 are involved in some important signaling pathways modulating cervical cancer cell invasion, migration, and drug sensitivity. Therefore, it is meaningful to verify the potential regulative effect of miR-361-3p on the expression of these genes in the future.

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“…In association with CIN2-3 and cervical carcinoma, several further miRNAs showing dysregulated expression have been reported, such as miR-218, 29a, −101, −140-5p [40][41][42][43][44]. In the study of Gocze et al (2015), progressively increased expression of miR-27a was demonstrated in CIN2-3 as compared to CIN1 and in squamous cell carcinoma (SCC) as compared to CIN2-3, while the levels of miR-34a were found to be lower in CIN2-3 when compared to CIN1 and in SCC in comparison to CIN2-3.…”

Section: Discussionmentioning

confidence: 99%

Increased miR-20b Level in High Grade Cervical Intraepithelial Neoplasia

Szekerczés

Galamb

Varga

et al. 2020

Pathol. Oncol. Res.

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Cervical cancer is a common malignant tumor worldwide ranking fourth in incidence and mortality among females, which was reduced significantly by cytology screening and human papilloma virus (HPV) DNA testing. The specificity of cytology is high; however, the sensitivity is low, in contrast to the HPV DNA testing. Despite the success of these measures, new biomarkers are still considered to aim increasing sensitivity and specificity of screening and diagnosis. Significant alterations in microRNA (miRNA) expression have been detected in several cancers with variable consistency. To investigate the stratification role of miRNAs between normal epithelium and cervical intraepithelial neoplasia (CIN2-3), we screened the expression of 667 miRNAs to identify significant markers (n = 10), out of them 9 miRNAs were applied in the study (miR-20b, −24, −26a, −29b, −99a, −100, −147, −212, −515-3p) along with RNU48 and U6 as the references. To benchmark the miRNAs, 22 paired (tumor-free and tumor tissue pairs) laser microdissection-obtained cervical formalin fixed, paraffin embedded tissue samples were assayed. The expression of miR-20b was 2.4 times higher in CIN2-3 samples as compared to normal tissues (p < 0.0001). In the HPV16-positive subsets of the samples (n = 13), miR-20b showed 2.9-times elevation (p < 0.001), whereas miR-515 was 1.15-times downregulated (p < 0.05) in CIN2-3 as compared to normal tissue. These results suggest the potential value of miR-20b as a statification biomarker in order to differentiate neoplastic and non-tumorous cases.

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Down-regulated serum microRNA-101 is associated with aggressive progression and poor prognosis of cervical cancer

Cited by 28 publications

References 33 publications

Diagnostic and prognostic implications of serum miR-101 in osteosarcoma

Diagnostic and prognostic implications of serum miR-101 in osteosarcoma

Preserved miR-361-3p Expression Is an Independent Prognostic Indicator of Favorable Survival in Cervical Cancer

Increased miR-20b Level in High Grade Cervical Intraepithelial Neoplasia

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