Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells

Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo

“…[36][37][38][39] Honokiol has been shown to have anti-carcinogenic potential in many organ systems. [17][18][19][20][21][22][23] In the current study, we further demonstrate that treatment of A549 or H1299 cell lines as an in vitro model with honokiol inhibits HDAC activity and suppresses the levels of class I HDAC proteins in a dose-and time-dependent manner, while enhancing HAT activity. Class I HDACs are responsible for deacetylation of the catalytic core for different co-repressor complexes resulting in transcriptional repression.…”

“…16 Previously, we have shown that honokiol exerts a chemopreventive effect on UV radiation-induced skin cancer and that this effect is associated with its targeting of mediators of inflammation and cell cycle regulators. 17 The anti-cancer activities of honokiol also have been demonstrated in a variety of cancer cell lines [18][19][20][21][22] and animal tumor xenograft models. 23 Honokiol has been found to alter various molecular targets that are known to affect tumor cell growth and their survival; however, little is known as to whether honokiol targets alterations in epigenetic regulators in cancer or targets events subsequent to the epigenetic effects.…”

Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells

“…It has been shown to have anti-angiogenic, anti-invasive, and antiproliferative activities in several types of human cancer cells [4], which include leukemia [5,6], human breast cancer cells [7,8], human hepatic cells [4], human multiple myeloma [9], human prostate cancer cells [10], and human squamous lung cancer cells [11]. In this study, we investigated the effect of honokiol, either alone or in combination with oxaliplatin, on the proliferation and apoptosis of the human colon cancer cell line HT-29.…”

Synthesis and Structure–Activity Relationships of Tetrahydro-β-carboline Derivatives as Anticancer and Cancer-chemopreventive Agents

“…The concentration of nitrite was calculated using a standard curve created with known concentrations of sodium nitrite. To evaluate the cytotoxic effects of compounds on RAW 264.7 cells under the same experimental condition, sulforhodamine B (SRB) assays were performed (24). Molecular docking.…”