Down-regulation of common NFκB-iNOS pathway by chronic Thalidomide treatment improves Hepatopulmonary Syndrome and Muscle Wasting in rats with Biliary Cirrhosis

Li, Tzu-Hao; Lee, Pei Chang; Lee, Kuei Chuan; Hsieh, Yun Cheng; Tsai, Chang Youh; Yang, Ying‐Ying; Huang, Shiang Fen; Tsai, Tung Hu; Hsieh, Shie Liang; Hou, Ming; Lin, Han Chieh; Lee, Shou Dong

doi:10.1038/srep39405

Cited by 23 publications

(11 citation statements)

References 53 publications

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“…In the present study, rats subjected to Gal showed a significant elevation in the renal and hepatic contents of NOx besides iNOS activity. These results are consistent with prior studies [ 29 , 42 , 44 - 46 ]. Previous findings have shown that NO, a potent vasodilator, plays an important role in the development of hyperdynamic syndrome and peripheral vasodilation during cirrhosis [ 3 ].…”

Section: Discussionsupporting

confidence: 94%

Protective Effects of the Third Generation Vasodilatory Βeta - Blocker Nebivolol against D-Galactosamine - Induced Hepatorenal Syndrome in Rats

Atwa¹,

Hegazy²,

Mohsen³

et al. 2017

Open Access Maced J Med Sci

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BACKGROUND:Renal dysfunction is very common in patients with advanced liver cirrhosis and portal hypertension. The development of renal failure in the absence of clinical, anatomical or pathological causes renal of failure is termed hepatorenal syndrome (HRS).AIM:The present study was constructed to investigate the possible protective effects of nebivolol (Nebi) against D-galactosamine (Gal)-induced HRS in rats.MATERIAL AND METHODS:Rats were treated with Nebi for ten successive days. On the 8th day of the experiment, they received a single dose of Gal. Serum levels of Cr, BUN, Na+ and K+ as well as AST, ALT, total bilirubin (TB), NH3 and endothelin-1 (ET-1) were determined following Gal administration. Moreover, renal and liver contents of MDA, GSH, F2-isoprostanes (F2-IPs), tumor necrosis factor-alpha (TNF-α), nuclear factor kappa-B (NF-κB), total nitric oxide (NO), in addition to activities of caspase-3 (Cas-3), heme oxygenase-1 (HO-1), inducible and endothelial NO synthase (iNOS and eNOS) enzymes were also assessed. Finally, histopathological examination was performed.RESULTS:Nebi attenuated Gal-induced renal and hepatic dysfunction. It also decreased the Gal-induced oxidative stress and inflammatory recruitment.CONCLUSION:Results demonstrated both nephroprotective and hepatoprotective effects of Nebi against HRS and suggested a role of its antioxidant, anti-inflammatory, anti-apoptotic and NO-releasing properties.

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Section: Discussionsupporting

confidence: 94%

Protective Effects of the Third Generation Vasodilatory Βeta - Blocker Nebivolol against D-Galactosamine - Induced Hepatorenal Syndrome in Rats

Atwa¹,

Hegazy²,

Mohsen³

et al. 2017

Open Access Maced J Med Sci

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“…However, another study reports that BACE1 −/− mice have enhanced insulin sensitivity [ 177 ]. Notably, hyperglycaemia increases BACE1-mediated production of Aβ [ 142 ], indicative of a potentially vicious cycle between amyloid and glucose dysregulation. This also highlights the likely contribution of diseases such as diabetes mellitus to AD development and emphasises the potential of nutritional intervention strategies as a means of treating and preventing AD.…”

Section: Glucose Metabolismmentioning

confidence: 99%

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

2020

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Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer’s disease (AD) and, as such, have become the focus of therapeutic development. Recent research, however, shows that these proteins have been highly conserved throughout evolution and may have crucial, physiological roles. Such functions may be lost during AD progression or be unintentionally disrupted by tau- or Aβ-targeting therapies. Tau has been revealed to be more than a simple stabiliser of microtubules, reported to play a role in a range of biological processes including myelination, glucose metabolism, axonal transport, microtubule dynamics, iron homeostasis, neurogenesis, motor function, learning and memory, neuronal excitability, and DNA protection. Aβ is similarly multifunctional, and is proposed to regulate learning and memory, angiogenesis, neurogenesis, repair leaks in the blood–brain barrier, promote recovery from injury, and act as an antimicrobial peptide and tumour suppressor. This review will discuss potential physiological roles of tau and Aβ, highlighting how changes to these functions may contribute to pathology, as well as the implications for therapeutic development. We propose that a balanced consideration of both the physiological and pathological roles of tau and Aβ will be essential for the design of safe and effective therapeutics.

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“…Then, fusion indices and myotube diameters were compared among different pretreatment groups. 27 Protein and mrnA levels in cultured c2c12 cells Then, various proteins and mRNAs of oxidative stress, autophagic, apoptotic, and lipolytic markers in cell lysates were measured with antibodies purchased from R&D Systems (Minneapolis, USA), Abcam (Cambridge, MA, USA), or Santa Cruz (Biotechnology, CA, USA) and various primers (table 1). TG content in cell lysates was measured by a TG Colorimetric assay kit (Cayman Chemical Company, Ann Arbor, MI, USA).…”

Section: Direct Effects Of Resveratrol On Palmitate-pretreated C2c12 mentioning

confidence: 99%

SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice

Huang

Hsu

et al. 2020

BMJ Open Gastroenterol

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BackgroundIn non-alcoholic steatohepatitis (NASH), muscle wasting was an aggravating factor for the progression of hepatic steatosis. This study explores the potential benefits of chronic treatment with resveratrol, a strong activator of SIRT1 on the muscle wasting of NASH mice.MethodsIn vivo and in vitro study, we evaluate the SIRT1-dependent mechanisms and effects of resveratrol administration for 6 weeks with high-fat-methionine and choline deficient diet-induced NASH mice and palmitate-pretreated C2C12 myoblast cells.ResultsResveratrol treatment improved grip strength and muscle mass of limbs, increased running distance and time on exercise wheels in NASH mice. There is a negative correlation between muscular SIRT1 activity and 3-nitrotyrosine levels of NASH and NASH-resv mice. The SIRT1-dependent effect of muscle wasting was associated with the suppression of oxidative stress, upregulation of antioxidants, inhibition of protein degradation, activation of autophagy, suppression of apoptotic activity, upregulation of lipolytic genes and the reduction of fatty infiltration in limb muscles of NASH mice. In vitro, resveratrol alleviated palmitate acid-induced oxidative stress, lipid deposition, autophagy dysfunction, apoptotic signals, and subsequently reduced fusion index and myotube formation of C2C12 cells. The beneficial effects of resveratrol were abolished by EX527.ConclusionsOur study suggests that chronic resveratrol treatment is a potential strategy for amelioration of hepatic steatosis and muscle wasting in NASH mouse model.

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Down-regulation of common NFκB-iNOS pathway by chronic Thalidomide treatment improves Hepatopulmonary Syndrome and Muscle Wasting in rats with Biliary Cirrhosis

Cited by 23 publications

References 53 publications

Protective Effects of the Third Generation Vasodilatory Βeta - Blocker Nebivolol against D-Galactosamine - Induced Hepatorenal Syndrome in Rats

Protective Effects of the Third Generation Vasodilatory Βeta - Blocker Nebivolol against D-Galactosamine - Induced Hepatorenal Syndrome in Rats

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice

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