Down-Regulation of CXCR4 in Mesenchymal Stem Cells by Septic Serum

Ghanbari, Mohammad Amin; Bolouki, Taghi Lashkar; Norouzi, Pirasteh; Bitaraf, Fatemeh Sadat; Bakhshi, Haniye; Atashi, Amir

doi:10.1007/s12288-022-01560-y

Search citation statements

Order By: Relevance

Paper Sections

Select...

Precondition Improves the Curative Effect Of Mscs On Sepsis ...1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Now only some in vitro data show that septic serum or LPS precondition affect the function of MSCs. [64][65][66] These questions need more investigation to summarize and illustrate in future.…”

Section: Precondition Improves the Curative Effect Of Mscs On Sepsis ...mentioning

confidence: 99%

Role of the regulation of mesenchymal stem cells on macrophages in sepsis

Xing

Wang

Cui

et al. 2023

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Sepsis is a common clinical critical disease with high mortality. The excessive release of cytokines from macrophages is the main cause of out-of-control immune response in sepsis. Mesenchymal stem cells (MSCs) are thought to be useful in adjunctive therapy of sepsis and related diseases, due to their function in immune regulation, anti-inflammatory, antibacterial, and tissue regeneration. Also there have been several successful cases in clinical treatment. Some previous studies have shown that MSCs regulate the function of macrophages through secreting cytokines and extracellular vesicles, or transferring mitochondria directly to target cells, which affects the progress of sepsis. Here, we review the regulation of MSCs on macrophages in sepsis, mainly focus on the regulation ways. We hope that will help to understand the immunological mechanism and also provide some clues for the clinical application of MSCs in the biotherapy of sepsis.

show abstract

Section: Precondition Improves the Curative Effect Of Mscs On Sepsis ...mentioning

confidence: 99%