Down-regulation of hepatic LDL receptor-related protein (LRP) in chronic renal failure

Abstract

CRF results in down-regulation of hepatic LRP. This abnormality can, at least in part, account for the previously documented elevation of plasma concentration and depressed clearance of chylomicron remnants and IDL in CRF.

A study of lipid profile in non-diabetic chronic kidney disease

“…Reasons for decrease in activity of these enzymes are not clear, possibly due to;  Presence of circulatory inhibitor of lipolytic enzymes in the serum  Changes in apoprotein concentrations which can affect lipoprotein lipase activity  Insulin resistance seen in renal insufficiency  Alteration of lipoprotein substrate. 12,13 Hypercholesteremia was found in 32 (22.86%) patients and decrease in HDL cholesterol was found in 30 (21.43%).…”

Role of dyslipidemia in impairment of energy metabolism, oxidative stress, inflammation and cardiovascular disease in chronic kidney disease

“…Chylomicron remnants and a portion of IDL are then removed by the liver via LDL receptor-related protein (LRP) [13]. However, CKD results in down-regulation of hepatic LRP [14] leading to accumulation of oxidation-prone and atherogenic chylomicron remnants in the plasma.…”

Lipid Abnormalities in Patients with Chronic Kidney Disease: Implications for the Pathophysiology of Atherosclerosis

“…Additionally, decreased LRP, LDL, and VLDL receptor activities demonstrated in animal studies may further negatively impact the removal of these lipoproteins 26) . In nephrectomized rats with chronic renal failure, the expression of hepatic LRP has been shown to be down-regulated 61) . Reduced hepatic LRP activity could potentially contribute to the impaired clearance and increased concentrations of CM-remnant and IDL-remnant particles, as well as hypertriglyceridemia observed in CKD patients 50,62) .…”