Down-regulation of hK7 in the sera of breast cancer and benign breast disease patients

Ejaz, Samina; Nasim, Faiz-ul-Hassan; Ashraf, Muhammad Aleem; Ahmad, Gulzar

doi:10.1016/j.heliyon.2017.e00356

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Previous research has demonstrated that KLK7 is implicated in various pathophysiological processes in diverse human organs, such as skin, lung, breast, prostate, and ovary [ 19 , 20 ]. Especially, in different types of cancer, including breast [ 21 ], ovarian [ 22 , 23 ], pancreatic [ 24 ], colorectal [ 25 ], and lung tumors [ 26 ], expression of KLK7 was shown to be dysregulated.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

et al. 2020

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Background High-grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of ovarian cancer. A growing body of evidence suggests tumor-supporting roles of several members of the kallikrein-related peptidase (KLK) family, including KLK5 and KLK7, in this cancer subtype. In normal physiology, KLK5 and KLK7 are the major proteases involved in skin desquamation. Moreover, in several cancer types KLK5 and KLK7 co-expression has been observed. Recently, we have shown that elevated KLK5 mRNA levels are associated with an unfavorable prognosis in HGSOC. Therefore, the aim of this study was to investigate the clinical significance of KLK7 mRNA expression and to explore its relation to KLK5 levels in HGSOC. Methods mRNA expression levels of KLK7 were quantified by qPCR in a well-characterized patient cohort afflicted with advanced high-grade serous ovarian cancer (FIGO III/IV, n = 139). Previously determined KLK5 mRNA as well as KLK5 and KLK7 antigen concentrations were used to evaluate the relationship between the expression patterns of both factors on the mRNA as well as protein level in tumor tissue of HGSOC patients. Results There were strong, significant positive correlations between KLK5 and KLK7 both at the mRNA and the protein level, suggesting coordinate expression of these proteases in HGSOC. In univariate analyses, elevated KLK7 levels as well as the combination of KLK5 + KLK7 (high and/or high versus low/low) were significantly associated with worse progression-free survival (PFS). High mRNA expression levels of KLK7 and the combination of KLK5 and KLK7 showed a trend towards significance for overall survival (OS). In multivariate analyses, KLK7 mRNA expression represented an unfavorable, statistically significant independent predictor for PFS and OS. Conclusions The findings imply that both increased KLK5 and KLK7 mRNA expression levels represent unfavorable prognostic biomarkers in advanced high-grade serous ovarian cancer, whereby multivariate analyses indicate that KLK7 mRNA exhibits a stronger predictive value as compared to KLK5 mRNA and the combination of KLK5 and KLK7.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

et al. 2020

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“…KLK7 is also known as human stratum corneum chymotryptic enzyme because of its early detection in human skin [ 5 ]. In breast cancer, KLK7 was significantly downregulated in the sera of breast cancer and benign breast disease patients, implying a role in the pathogenesis of infiltrating ductal carcinoma [ 6 ]. It has been reported that KLK7 and KLK10 are two of the most upregulated genes in papillary thyroid carcinoma, which are involved in cell adhesion and extracellular matrix remodeling [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of expression and prognosis of KLK7 in ovarian cancer

Chen¹,

Zhu²,

Yang³

et al. 2020

Open Medicine

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BackgroundOvarian cancer is one of the common malignant tumors in female reproductive organs. Kallikrein-related peptidase (KLK) 7 is a secreted serine peptidase that is related to different cancer. To investigate the expression and significance of KLK7 in ovarian cancer.Materials and methodsThe expression of KLK7 in human ovarian cancer was evaluated by Oncomine and Cancer Cell Line Encyclopedia database. Then the co-expression genes relevant to the KLK7 gene were analyzed by the Pearson correlation test. Finally, the impact of KLK7 on clinical prognosis was investigated in distinct subtypes of ovarian cancer patients by UALCAN database and Kaplan–Meier plotter database.ResultsIt was found that the expression of KLK7 was higher in ovarian cancer compared with other types of cancer, such as gastric cancer and pancreatic cancer. The expression of KLK7 was found to be increased in four various ovarian cancer data sets compared with the healthy tissues. In addition, upregulation of KLK7 expression was associated with age and cancer stage. Moreover, survival analysis revealed that higher KLK7 expression was negatively associated with progression-free survival.ConclusionKnowledge of the expression of KLK7 may be useful for better understanding the outcome in ovarian cancer patients.

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Overview of tissue kallikrein and kallikrein-related peptidases in breast cancer

Figueroa

Molina

Bhoola

et al. 2018

Biological Chemistry

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The kallikrein family comprises tissue kallikrein and 14 kallikrein-related peptidases (KLKs) recognized as a subgroup of secreted trypsin- or chymotrypsin-like serine proteases. KLKs are expressed in many cellular types where they regulate important physiological activities such as semen liquefaction, immune response, neural development, blood pressure, skin desquamation and tooth enamel formation. Tissue kallikrein, the oldest member and kinin-releasing enzyme, and KLK3/PSA, a tumor biomarker for prostate cancer are the most prominent components of the family. Additionally, other KLKs have shown an abnormal expression in neoplasia, particularly in breast cancer. Thus, increased levels of some KLKs may increase extracellular matrix degradation, invasion and metastasis; other KLKs modulate cell growth, survival and angiogenesis. On the contrary, KLKs can also inhibit angiogenesis and produce tumor suppression. However, there is a lack of knowledge on how KLKs are regulated in tumor microenvironment by molecules present at the site, namely cytokines, inflammatory mediators and growth factors. Little is known about the signaling pathways that control expression/secretion of KLKs in breast cancer, and further how activation of PAR receptors may contribute to functional activity in neoplasia. A better understanding of these molecular events will allow us to consider KLKs as relevant therapeutic targets for breast cancer.

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Down-regulation of hK7 in the sera of breast cancer and benign breast disease patients

Cited by 4 publications

References 26 publications

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

Analysis of expression and prognosis of KLK7 in ovarian cancer

Overview of tissue kallikrein and kallikrein-related peptidases in breast cancer

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