2020
DOI: 10.1016/j.ejphar.2020.173618
|View full text |Cite
|
Sign up to set email alerts
|

Down-regulation of lncRNA Gas5 promotes hypoxia-induced pulmonary arterial smooth muscle cell proliferation by regulating KCNK3 expression

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
14
0
1

Year Published

2021
2021
2023
2023

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 15 publications
(15 citation statements)
references
References 43 publications
0
14
0
1
Order By: Relevance
“…The possible reason might be that: (1) lnc‐GAS5 inhibited the hypoxia‐induced pulmonary arterial smooth muscle cell proliferation by regulating KCNK3 expression, therefore lnc‐GAS5 played a protective role in the lung injury model. Hence, lnc‐GAS5 is negatively related to SOFA‐Respiratory system score, 30 (2) lnc‐GAS5 might inhibit the renal cell pyroptosis in sepsis‐induced renal injury though inhibiting miR‐579‐3p to activate SIRT1/PGC‐1 alpha/Nrf2 signaling pathway, therefore, lnc‐GAS5 negatively associated with SOFA‐Renal system score, 17 (3) lnc‐GAS5 could inhibit the inflammatory process, which might regulate the coagulation process, therefore, the lnc‐GAS5 was related to the SOFA‐Coagulation score. However, this hypothesis needed further exploration.…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…The possible reason might be that: (1) lnc‐GAS5 inhibited the hypoxia‐induced pulmonary arterial smooth muscle cell proliferation by regulating KCNK3 expression, therefore lnc‐GAS5 played a protective role in the lung injury model. Hence, lnc‐GAS5 is negatively related to SOFA‐Respiratory system score, 30 (2) lnc‐GAS5 might inhibit the renal cell pyroptosis in sepsis‐induced renal injury though inhibiting miR‐579‐3p to activate SIRT1/PGC‐1 alpha/Nrf2 signaling pathway, therefore, lnc‐GAS5 negatively associated with SOFA‐Renal system score, 17 (3) lnc‐GAS5 could inhibit the inflammatory process, which might regulate the coagulation process, therefore, the lnc‐GAS5 was related to the SOFA‐Coagulation score. However, this hypothesis needed further exploration.…”
Section: Discussionmentioning
confidence: 97%
“…These findings might be explained as follows: lnc-GAS5 was related to the outbreak of inflammation and multi-organ injury such as lung injury and renal injury, whose injury was associated with higher mortality risk in sepsis patients, therefore, lnc-GAS5 could predict the 28 days mortality of sepsis patients. 17,30 Several limitations were nonnegligible in this study. Firstly, the lnc-GAS5 was only detected after the enrollment of all subjects, while its multi-time point detection to monitor the progression of sepsis patients was needed and should be conducted in further study.…”
Section: Discussionmentioning
confidence: 97%
“…Additionally, GAS5 regulates SMC function possibly via β-catenin signaling [77]. Recently, in the lung of hypoxiainduced PH rats and hypoxic PASMCs, GAS5 expression was found to be significantly downregulated [52]. Furthermore, silencing of GAS5 expression with siRNA stimulated migration and proliferation of HPASMCs [52].…”
Section: Lncrna Pulmonary Arterial Hypertension Related Factor (Pahrf)mentioning
confidence: 99%
“…Recently, in the lung of hypoxiainduced PH rats and hypoxic PASMCs, GAS5 expression was found to be significantly downregulated [52]. Furthermore, silencing of GAS5 expression with siRNA stimulated migration and proliferation of HPASMCs [52]. Mechanistically, GAS5 regulates migration and proliferation of HPASMCs potentially via Gas5/miR-23b-3p/KCNK3 signaling axis [52].…”
Section: Lncrna Pulmonary Arterial Hypertension Related Factor (Pahrf)mentioning
confidence: 99%
See 1 more Smart Citation