Down-regulation of NAMPT expression by mir-206 reduces cell survival of breast cancer cells

Hesari, Zahra; Nourbakhsh, Mitra; Hosseinkhani, Saman; Abdolvahabi, Zohreh; Alipour, Mohsen; Tavakoli-Yaraki, Masoumeh; Ghorbanhosseini, Seyedeh Sara; Yousefi, Zeynab; Jafarzadeh, Meisam; Yarahmadi, Sahar

doi:10.1016/j.gene.2018.06.021

Cited by 44 publications

(45 citation statements)

References 55 publications

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“…Recent investigation on head and neck squamous cell carcinoma reported that miR‐206 inhibits cell invasion and migration via downregulating MMP‐2 . An increasing body of studies have demonstrated the role of miR‐206 as a tumor‐inhibiting factor in a variety of cancers, including TC …”

Section: Discussionmentioning

confidence: 99%

“…9 An increasing body of studies have demonstrated the role of miR-206 as a tumor-inhibiting factor in a variety of cancers, including TC. 6,8,16,18 RAP1B is a member of the small GTPase Ras family, functioning as a molecular switch and plays a crucial role in cell activities, including cell proliferation, migration, and invasion. Recent studies have revealed the abnormal occurrence of RAP1B in several malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…An increasing number of investigations have reported aberrant expression of miR‐206 in multiple cancers, including breast cancer, lung cancer, and colon cancer, and established that miR‐206 functions as a suppressor in tumor progression. For instance, elevated miR‐206 expression inhibited proliferation and invasion via decreasing expression of NAMPT and coronin 1C in breast cancer, and HDAC6 in head and neck squamous cell carcinoma . It has also been reported that miR‐206 is involved in chemoresistance of colon cancer cells to 5‐FU .…”

Section: Introductionmentioning

confidence: 99%

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miR‐206 inhibits thyroid cancer proliferation and invasion by targeting RAP1B

Wang

et al. 2019

J of Cellular Biochemistry

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Thyroid cancer (TC) is one of the primary tumors arisen from endocrine system. The purpose of this study was to investigate the underlying mechanism by which RAP1B (Ras‐related protein Rap‐1b) modulates microRNA (miR)‐206 related effects on TC cells. Expression of miR‐206 and RAP1B was analyzed in cells and tissues. miR‐206 mimics or inhibitors and RAP1B vector were used in functional experiments to investigate the effects of miR‐206 and RAP1B on cell activities including proliferation, migration, and invasion. Luciferase assay was performed to explore the association between miR‐206 and RAP1B. The influence of miR‐206 on tumorigenesis of TC cells was investigated using an ex vivo model. Our results demonstrated the reduce of miR‐206 in TC tissues and cell lines in which RAP1B was increased. Overexpression of miR‐206 significantly inhibited the functional capacities of TPC‐1 cells including proliferation, invasion, and migration, most likely, through reducing the expression of RAP1B. Xenograft experiment showed that increased miR‐206 could effectively inhibit the tumorigenesis of TC cells. Our study showed that miR‐206 negatively regulated cell activities of proliferation, invasion, and migration in TC via suppressing RAP1B expression, suggesting that miR‐206 exerts a vital role in TC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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miR‐206 inhibits thyroid cancer proliferation and invasion by targeting RAP1B

Wang

et al. 2019

J of Cellular Biochemistry

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“…Zhang et al (2013[54]) showed that miR-26b inhibited NAMPT expression at the protein and mRNA levels by binding to the its 3′-UTR in colorectal cancer cell lines (SW480, SW1116, LoVo, and HCT116). Hesari et al (2018[19]) reported that miR-206 inhibited NAMPT expression at the translational level by directly binding to its 3′-UTR. Adyshev et al also showed that miR-374a and miR-568 reduced the level of mRNA and protein of NAMPT in human lung endothelial cells (Adyshev et al, 2014[1]).…”

Section: Discussionmentioning

confidence: 99%

“…The 3′-untranslated region (3 ′ -UTR) of NAMPT was amplified by PCR as previously described (Hesari et al, 2018[19]). The digestion products were cloned downstream of the Renilla gene in psiCHECK2 plasmid (Promega, USA), after digestion of the PCR products with XhoI and NotI enzymes (Fermentas, USA).…”

Section: Methodsmentioning

confidence: 99%

MicroRNA-494 induces breast cancer cell apoptosis and reduces cell viability by inhibition of nicotinamide phosphoribosyltransferase expression and activity

Ghorbanhosseini

Nourbakhsh

Zangooei

et al. 2019

EXCLI Journal; 18:Doc838; ISSN 1611-2156

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The role of NFATc1 in the progression and metastasis of prostate cancer: A review on the molecular mechanisms and signaling pathways

Hasani,

Fathabadi,

Saeidi

et al. 2023

Cell Biology International

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A common type of cancer among men is the prostate cancer that kills many people every year. The multistage of this disease and the involvement of the vital organs of the body have reduced the life span and quality of life of the people involved and turned the treatment process into a complex one. NFATc1 biomarker contributes significantly in the diagnosis and treatment of this disease by increasing its expression in prostate cancer and helping the proliferation, differentiation, and invasion of cancer cells through different signaling pathways. NFATc1 is also able to target the metabolism of cancer cells by inserting specific oncogene molecules such as c‐myc that it causes cell growth and proliferation. Bone is a common tissue where prostate cancer cells metastasize. In this regard, the activity of NFATc1, through the regulation of different signaling cascades, including the RANKL/RANK signaling pathway, in turn, increases the activity of osteoclasts, and as a result, bone tissue is gradually ruined. Using Silibinin as a medicinal plant extract can inhibit the activity of osteoclasts related to prostate cancer by targeting NFATc. Undoubtedly, NFATc1 is one of the effective oncogenes related to prostate cancer, which has the potential to put this cancer on the path of progression and metastasis. In this review, we will highlight the role of NFATc1 in the progression and metastasis of prostate cancer. Furthermore, we will summarize signaling pathways and molecular mechanism, through which NFATc1 regulates the process of prostate cancer.

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Down-regulation of NAMPT expression by mir-206 reduces cell survival of breast cancer cells

Cited by 44 publications

References 55 publications

miR‐206 inhibits thyroid cancer proliferation and invasion by targeting RAP1B

miR‐206 inhibits thyroid cancer proliferation and invasion by targeting RAP1B

MicroRNA-494 induces breast cancer cell apoptosis and reduces cell viability by inhibition of nicotinamide phosphoribosyltransferase expression and activity

The role of NFATc1 in the progression and metastasis of prostate cancer: A review on the molecular mechanisms and signaling pathways

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