Down-regulation of particulate protein kinase C? and up-regulation of nuclear activator protein-1 DNA binding in liver following in vivo exposure of B6C3F1 male mice to heptachlor epoxide

Hansen, Mark E.; Matsumura, Fumio

doi:10.1002/1099-0461(2001)15:1<1::aid-jbt1>3.0.co;2-0

Cited by 9 publications

(3 citation statements)

References 50 publications

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“…[41,42] Supporting this mechanism, it has been found recently that most effects of polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlordibenzo-p-dioxin were mediated by the Ah receptor. [45] In addition, it has been found that the activities of activator protein-1 DNA and protein kinase c were correlated to heptachlor epoxide levels and induced tumors in mice. Supporting last suggestion, it has been reported that lindane treatment was found to induce the activity of heme oxygenase.…”

Section: Resultsmentioning

confidence: 99%

“…[41] The mechanism of cytochrome P450 induction might be also due to enhancing of delta-aminolevulinic acid (ALA) synthetase, the initial and rate-limiting step in the biosynthesis of the heme moiety of cytochrome P450s or may be due to inhibition of heme oxygenase, the first and rate-limiting enzyme in heme degradation, since P450s are hemoproteins. [45] The glutathione S-transferases (GSTs) are, a group of inducible enzymes, important in the detoxication of many different xenobiotics in mammals. [39] On the other hand, repeated-dose treatments of mice with sumithion, dursban, chlordane, methoxychlor, and heptachlor epoxide decreased the total hepatic content of cytochrome P450, AHH, NDMA-dI (Tables 1 and 3).…”

Section: Resultsmentioning

confidence: 99%

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Carcinogen-Metabolizing Enzymes and Insecticides

Sheweita¹

2004

J Environ Sci Health B Pest Food Contam Agricul Wastes

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The present study was under taken to demonstrate the effect of some commonly used insecticides on the activity of cytochrome P450 system including cytochrome b5, aryl hydrocarbon [benzo(a)pyrene] hydroxylase (AHH), N-nirosodimethylamine N-demethylase I [NDMA-dI] and NADPH-cytochrome c reductase as phase I of drug oxidation. In addition, the activity of glutathione S-transferase (GST), glutathione reductase (GR), and the level of glutathione (GSH) were determined in the liver of male mice after oral administration of sumithion, dursban, chlordane, methoxychlor, heptachlor epoxide, and lindane as single (24h) or as repeated doses for six consecutive days. Oral administration of sumithion, dursban, chlordane, methoxychlore, and heptachlor epoxide as repeated doses decreased: (i) the hepatic content of cytochrome P450 by 36, 37, 47, 37, and 67%, respectively, (ii) AHH activity by 28, 29, 70, 31, and 79%, respectively, (iii) NDMA-dI activity by 43, 44, 32, 27, and 31, respectively. On the other hand, sumithion, chlordane, and methoxychlore induced the activity of NADPH-cytochrome c reductase by 45, 62, and 43 respectively after repeated dose treatments. In addition, single and repeated-dose treatments of mice with lindane induced: (i) cytochrome P450 by 23 and 65%, respectively, (ii) cytochrome b5 by 49 and 131%, respectively, (iii) AHH activity by 64 and 50%, respectively. Repeated-dose treatments of mice with chlordane, methoxychlore, and heptachlor epoxide decreased the GSH level by 42, 38, and 68%, respectively and GST activity by 44, 44, and 55% respectively. Moreover, single- and repeated-dose treatments of mice with lindane decreased the GSH levels by 40 and 54%, respectively, and induced GST activity by 25 and 41%, respectively. Interestingly, single-dose treatments with chlordane, methoxychlore, and heptachlor epoxide decreased the activity of GR by 32, 38, and 31, respectively whereas repeated doses of these compounds induced such activity by 83, 50, and 64%, respectively. It is concluded that modifications in cytochrome P450 system by pesticides could potentiate the toxicity and carcinogenicity of environmental carcinogens such as polycyclic aromatic hydrocarbon and N-nirosodimethylamine (NDMA).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Carcinogen-Metabolizing Enzymes and Insecticides

Sheweita¹

2004

J Environ Sci Health B Pest Food Contam Agricul Wastes

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“…Heptachlor also trigger proliferation of quiescent hepatocytes and activated protein kinase C MAPKs in vitro. In mice, heptachlor interacted with protein kinase C, particularly the epsilon isoform, which is believed to be important for tumour promotion (Hansen and Matsumura, 2001). In human lymphocytes heptachlor down regulated tumour suppressor gene p53 and the retinoblastoma (Rb) gene.…”

Section: Intercellular Communication and Other Biochemical Effectsmentioning

confidence: 99%

Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related heptachlor as an undesirable substance in animal feed

2007

EFS2

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Heptachlor [MAK Value Documentation in German language, 2009]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 47. Lieferung, Ausgabe 2009 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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Down-regulation of particulate protein kinase C? and up-regulation of nuclear activator protein-1 DNA binding in liver following in vivo exposure of B6C3F1 male mice to heptachlor epoxide

Cited by 9 publications

References 50 publications

Carcinogen-Metabolizing Enzymes and Insecticides

Carcinogen-Metabolizing Enzymes and Insecticides

Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related heptachlor as an undesirable substance in animal feed

Heptachlor [MAK Value Documentation in German language, 2009]

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