Down-regulation of peroxisome proliferator-activated receptor gamma in human cervical carcinoma

Jung, Tae-Il; Baek, Won-Ki; Suh, Seong-Il; Jang, Byeong‐Churl; Song, Dae‐Kyu; Bae, Jae‐Hoon; Kwon, Kun-Young; Bae, Ji-Hyun; Cha, Soon-Do; Bae, Insoo; Cho, Chi-Heum

doi:10.1016/j.ygyno.2005.01.019

Cited by 40 publications

(29 citation statements)

References 33 publications

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“…However, peroxisome proliferatoractivated receptors (PPAR) act as transcription factors, binding with retinoid X receptor (RXR), and have been implicated in tumorigenesis (17). Moreover, PPARg has been shown to be downregulated in cervical tumors (18). Because ACAA1 is regulated by PPAR, we speculate that a common PPAR ligand, coactivator, or RXR regulatory mechanism may be involved in the progression of early cervical neoplasia (Fig.…”

Section: Discussionmentioning

confidence: 97%

Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates

et al. 2007

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This study is the first comprehensive, integrated approach to examine grade-specific changes in gene expression along the entire neoplastic spectrum of cervical intraepithelial neoplasia (CIN) in the process of cervical carcinogenesis. This was accomplished by identifying gene expression signatures of disease progression using cDNA microarrays to analyze RNA from laser-captured microdissected epithelium and underlying stroma from normal cervix, graded CINs, cancer, and patientmatched normal cervical tissues. A separate set of samples were subsequently validated using a linear mixed model that is ideal to control for interpatient gene expression profile variation, such as age and race. These validated genes were ultimately used to propose a genomically based model of the early events in cervical neoplastic transformation. In this model, the CIN 1 transition coincides with a proproliferative/immunosuppression gene signature in the epithelium that probably represents the epithelial response to human papillomavirus infection. The CIN 2 transition coincides with a proangiogenic signature, suggesting a cooperative signaling interaction between stroma and tumor cells. Finally, the CIN 3 and squamous cell carcinoma antigen transition coincide with a proinvasive gene signature that may be a response to epithelial tumor cell overcrowding. This work strongly suggests that premalignant cells experience a series of microenvironmental stresses at the epithelium/ stroma cell interface that must be overcome to progress into a transformed phenotype and identifies the order of these events in vivo and their association with specific CIN transitions. [Cancer Res 2007;67(15):7113-23]

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Section: Discussionmentioning

confidence: 97%

Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates

et al. 2007

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“…Another study shows that the expression level of PPARγ in gastric carcinoma cells was significantly lower than that in normal controls [7]. Many studies show a significant reduction of PPARγ expression in follicular thyroid cancer, cervical carcinoma, and esophageal cancer [8,9,10]. Conversely, PPARγ expression levels in advanced prostate cancer tissues are found to be higher than those in low-risk prostate cancer and benign prostate hyperplasia specimens [11].…”

Section: Pparγ and Tumorsmentioning

confidence: 99%

PPARγ against Tumors by Different Signaling Pathways

Zhang

Xü

et al. 2013

Oncol Res Treat

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The peroxisome proliferator-activated receptor-γ (PPARγ) belongs to the nuclear hormone receptor superfamily, and is expressed in adipose tissue, skeletal muscle, spleen, heart, liver, placenta, lung, and ovary. PPARγ is a critical regulator of inflammation, adipocyte differentiation, glucose homeostasis, and tumorigenesis. The mechanism of PPARγ on tumor suppression is still unclear, but plenty of evidence shows that PPARγ provides new therapeutic targets for cancer. Here we give a review of how PPARγ and its ligands regulate tumorigenesis by different pathways.

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“…The cross relaxation occurred at 500 1C [34] and affected the fluorescence intensity of the 5 D 4 transition significantly. For that cause, the energy level of 5 D 4 should be identified in molten LiCl-KCl salt to excite the electrons from the ground level to the 5 D 4 state merely to rule out the emission from the 5 D 3 state.…”

Section: Energy Transfer Mechanism Of Tb(iii)-ln(iii) Binary Systemmentioning

confidence: 99%

“…However, it has not been actively applied for molten salt chemistry at high temperature. Recently, a few fluorescence spectroscopic measurements on single lanthanide element in molten chloride salts have been reported [32][33][34][35][36]. Nonetheless, there have not yet been adequate experimental evidences to prove chemical structure of a mixture of lanthanides in high temperature molten salts.…”

Section: Introductionmentioning

confidence: 99%

Structural investigation of the Tb(III)–Ln(III) (Ln=Nd, Sm) binary system in molten LiCl–KCl eutectic salt by fluorescence resonance energy transfer

Kim

Lim

Yun

2015

Journal of Luminescence

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Down-regulation of peroxisome proliferator-activated receptor gamma in human cervical carcinoma

Cited by 40 publications

References 33 publications

Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates

Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates

PPARγ against Tumors by Different Signaling Pathways

Structural investigation of the Tb(III)–Ln(III) (Ln=Nd, Sm) binary system in molten LiCl–KCl eutectic salt by fluorescence resonance energy transfer

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Down-regulation of peroxisome proliferator-activated receptor gamma in human cervical carcinoma

Cited by 40 publications

References 33 publications

Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates

Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates

PPAR&#947; against Tumors by Different Signaling Pathways

Structural investigation of the Tb(III)–Ln(III) (Ln=Nd, Sm) binary system in molten LiCl–KCl eutectic salt by fluorescence resonance energy transfer

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PPARγ against Tumors by Different Signaling Pathways