Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression

Guo, Xiaoyun; Li, Zezhi; Zhang, Chen; Yi, Zhenghui; Li, Haozhe; Cao, Lan; Yuan, Chen; Wu, Hong; Wu, Zhiguo; Peng, Daihui; Xia, Weiliang; Zhao, Guangsheng; Wang, Fan; Yu, Shunying; Cui, Donghong; Xu, Yifeng; Golam, Chowdhury M.I.; Smith, Alicia K.; Wang, Tong; Fang, Yiru

doi:10.1016/j.jpsychires.2015.07.011

Cited by 6 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although each medical unit dispatched medical personnel with professional and psychological qualities to participate in the work of assisting Hubei to fight the epidemic, at the end of assistance work, 31.6%, 23.6%, and 55.6% of the participants still showed symptoms of depression, anxiety, and impaired sleep quality, respectively. Our results are largely consistent with those of other studies, which have reported that during a major public health emergency, the medical staff faced the risk of experiencing serious mental health consequences due to high-intensity fatigue [ 13 – 15 ]. As a COVID-19 confrontation, research evidence demonstrated that 50.4%, 44.6%, and 34.0% of the medical staff experienced depression, anxiety, and insomnia, respectively [ 4 ], showing a worse mental health status than is shown by our research.…”

Section: Discussionsupporting

confidence: 92%

Two-stage mental health survey of first-line medical staff after ending COVID-19 epidemic assistance and isolation

You

et al. 2021

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Facing with COVID-19 epidemic such a catastrophic health emergency, the mental health status of medical staff deserves attention. We conducted a two-stage of psychological status monitoring after the end of the assistance and 14 days of isolation, further targeted the vulnerable groups in need of intervention. The study is a cross-sectional survey on 1156 Yunnan medical staff aid to Hubei. Used Cluster sampling method to collect data at 2 time points (at the end of returning from Wuhan and the 14th day of isolation), from March 18, 2020 to April 6, 2020. Female and nurse had higher rates of depressive symptoms than male and doctors and other occupations. The proportion of female with mild and above moderate anxiety levels (22.91%, 2.61%) was higher than male (17.35%, 1.03%) (p < 0.05). Female had a better impaired sleep quality (45.06%, 17.49%) more than male (28.57%, 7.94%). Medical staff supported in Wuhan and with junior professional titles reported a higher proportion of sleep quality impairment. At the 14th isolation day stage, the proportion of nurses changed from depression to health (9.15%) and from health to depression (6.1%) better than doctors. The front-line medical staffs had suffered greater psychological pressure in the treatment process of major public health emergency. Researches on the dynamic monitor for the change of psychological status after aiding epidemic areas were still in relatively blank stage. Targeting the vulnerable characteristics of aiding medical staff is significant for effective psychological intervention and sustainable operation of health system.

show abstract

Section: Discussionsupporting

confidence: 92%

Two-stage mental health survey of first-line medical staff after ending COVID-19 epidemic assistance and isolation

You

et al. 2021

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…These variants may exert their functional effects through the immune system [ 84 ]. The PRKCB gene expression in peripheral blood mononuclear cells (PBMC) was shown to be down-regulated in depressed patients [ 85 ], and an association with a combination of three SNPs at PRKCB gene with major depression was reported [ 86 ]. PRKCB also act as a regulator of the HPA axis response to stress, phosphorylating CREB1, which directly regulates the expression of BDNF, TrkB and the glucocorticoid receptor [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

A game changer for bipolar disorder diagnosis using RNA editing-based biomarkers

et al. 2022

View full text Add to dashboard Cite

In clinical practice, differentiating Bipolar Disorder (BD) from unipolar depression is a challenge due to the depressive symptoms, which are the core presentations of both disorders. This misdiagnosis during depressive episodes results in a delay in proper treatment and a poor management of their condition. In a first step, using A-to-I RNA editome analysis, we discovered 646 variants (366 genes) differentially edited between depressed patients and healthy volunteers in a discovery cohort of 57 participants. After using stringent criteria and biological pathway analysis, candidate biomarkers from 8 genes were singled out and tested in a validation cohort of 410 participants. Combining the selected biomarkers with a machine learning approach achieved to discriminate depressed patients (n = 267) versus controls (n = 143) with an AUC of 0.930 (CI 95% [0.879–0.982]), a sensitivity of 84.0% and a specificity of 87.1%. In a second step by selecting among the depressed patients those with unipolar depression (n = 160) or BD (n = 95), we identified a combination of 6 biomarkers which allowed a differential diagnosis of bipolar disorder with an AUC of 0.935 and high specificity (Sp = 84.6%) and sensitivity (Se = 90.9%). The association of RNA editing variants modifications with depression subtypes and the use of artificial intelligence allowed developing a new tool to identify, among depressed patients, those suffering from BD. This test will help to reduce the misdiagnosis delay of bipolar patients, leading to an earlier implementation of a proper treatment.

show abstract

Involvement of protein kinase C beta1-serotonin transporter system dysfunction in emotional behaviors in stressed mice

Ito

Hiramatsu

Uchida

et al. 2020

Neurochemistry International

View full text Add to dashboard Cite

Down-regulation of PRKCB1 expression in Han Chinese patients with subsyndromal symptomatic depression

Cited by 6 publications

References 42 publications

Two-stage mental health survey of first-line medical staff after ending COVID-19 epidemic assistance and isolation

Two-stage mental health survey of first-line medical staff after ending COVID-19 epidemic assistance and isolation

A game changer for bipolar disorder diagnosis using RNA editing-based biomarkers

Involvement of protein kinase C beta1-serotonin transporter system dysfunction in emotional behaviors in stressed mice

Contact Info

Product

Resources

About