Down-regulation of tissue levels of serine protease inhibitor (vaspin) in psoriasis vulgaris patients: a possible mechanism of narrowband ultraviolet B radiation

Sayed, Khadiga S; Said, Eman Raafat; Mohammed, Faisal; Algorhary, Mira; Rashed, Laila Ahmed

doi:10.1007/s00403-019-01947-4

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…The role of vaspin in skin diseases is poorly understood. Vaspin has been hypothesized to play a role in the pathogenesis of inflammatory cutaneous conditions such as psoriasis (Saalbach et al, 2016;Sayed et al, 2019) and systemic sclerosis ( _ Zó łkiewicz et al, 2019). In addition, it was found to inhibit kallikrein 7 and 14, two proteases previously shown to play a critical role during skin desquamation (de Veer et al, 2017;Stefansson et al, 2006), but it is unclear whether it is necessary for proper epidermal differentiation.…”

Section: Functional Consequences Of Vaspin Deficiencymentioning

confidence: 99%

Loss-of-Function Variants in SERPINA12 Underlie Autosomal Recessive Palmoplantar Keratoderma

Mohamad

Sarig

Malki

et al. 2020

Journal of Investigative Dermatology

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Section: Functional Consequences Of Vaspin Deficiencymentioning

confidence: 99%

Loss-of-Function Variants in SERPINA12 Underlie Autosomal Recessive Palmoplantar Keratoderma

Mohamad

Sarig

Malki

et al. 2020

Journal of Investigative Dermatology

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“…Of relevance to the present study, a role for serine proteases and their endogenous inhibitors (Kallikreins-Related Peptidases ( 48 , 49 ), Marapsin ( 50 ), Vaspin ( 51 ), SerpinB7 ( 52 ), Leukocyte Elastase ( 53 )) in psoriasis have been investigated. When compared with other classes of proteases, serine proteases are among the most likely to mediate psoriasis pathology since a majority are released to the extracellular milieu indiscriminately ( 54 ).…”

Section: Discussionmentioning

confidence: 99%

Granzyme K mediates IL-23-dependent inflammation and keratinocyte proliferation in psoriasis

Richardson,

Aubert,

Turner

et al. 2024

Front. Immunol.

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Psoriasis is an inflammatory disease with systemic manifestations that most commonly presents as itchy, erythematous, scaly plaques on extensor surfaces. Activation of the IL-23/IL-17 pro-inflammatory signaling pathway is a hallmark of psoriasis and its inhibition is key to clinical management. Granzyme K (GzmK) is an immune cell-secreted serine protease elevated in inflammatory and proliferative skin conditions. In the present study, human psoriasis lesions exhibited elevated GzmK levels compared to non-lesional psoriasis and healthy control skin. In an established murine model of imiquimod (IMQ)-induced psoriasis, genetic loss of GzmK significantly reduced disease severity, as determined by delayed plaque formation, decreased erythema and desquamation, reduced epidermal thickness, and inflammatory infiltrate. Molecular characterization in vitro revealed that GzmK contributed to macrophage secretion of IL-23 as well as PAR-1-dependent keratinocyte proliferation. These findings demonstrate that GzmK enhances IL-23-driven inflammation as well as keratinocyte proliferation to exacerbate psoriasis severity.

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“…Similar results of reduced vaspin levels in psoriatic lesions in relation to healthy skin were also obtained by Sayed et al . [ 27 ]. These results highlight the important role of vaspin in psoriasis and the need for further research.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, an upward trend in vaspin levels after treatment observed may be due to reduced skin involvement or improvement of the inflammatory state. Referring to the study showing a reduced concentration of vaspin in psoriatic lesions, it was found that improvement of psoriatic plaques by narrowband ultraviolet B radiation is associated with an upregulation of tissue vaspin levels [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Decreased levels of vaspin and its potential association with cardiometabolic risk in patients with psoriasis: preliminary results

Kiluk¹,

Baran²,

Kamiński³

et al. 2022

pdia

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Introduction Omentin and vaspin are considered to have beneficial effects preventing the development of metabolic disorders which are common comorbidities in psoriasis. Aim To evaluate the serum level of these adipokines in psoriatic patients and elucidate possible associations with disease activity, metabolic or inflammatory parameters and systemic treatment. Material and methods Thirty-three patients with active plaque-type psoriasis and 11 healthy controls participated in the study. Blood samples were collected before and after 3 months of treatment with acitretin or methotrexate. Results Serum vaspin concentration in psoriatic patients was significantly lower than in the control group ( p < 0.05). No correlation between adipokines and severity of disease evaluated with PASI was found. However, median vaspin levels decreased with the severity of skin lesions and the omentin level was higher in patients with severe disease versus those with moderate form ( p < 0.05). The vaspin level correlated with BMI of psoriatic patients ( p < 0.05), with cholesterol and triglycerides levels ( p = 0.054, p = 0.049, respectively). No significant effect of systemic treatment on omentin levels was found. Regarding vaspin, we observed an upward trend in its concentration after treatment. Conclusions Omentin and vaspin may play a modulating role in the systemic inflammation present in psoriasis and thus may contribute to the development of metabolic complications.

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Down-regulation of tissue levels of serine protease inhibitor (vaspin) in psoriasis vulgaris patients: a possible mechanism of narrowband ultraviolet B radiation

Cited by 5 publications

References 17 publications

Loss-of-Function Variants in SERPINA12 Underlie Autosomal Recessive Palmoplantar Keratoderma

Loss-of-Function Variants in SERPINA12 Underlie Autosomal Recessive Palmoplantar Keratoderma

Granzyme K mediates IL-23-dependent inflammation and keratinocyte proliferation in psoriasis

Decreased levels of vaspin and its potential association with cardiometabolic risk in patients with psoriasis: preliminary results

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