Down's syndrome and the thyroid

Kennedy, R. L.; Jones, T. H.; Cuckle, Howard

doi:10.1111/j.1365-2265.1992.tb01475.x

Cited by 45 publications

(28 citation statements)

References 63 publications

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“…TSH levels were not so elevated (5.1 to 29.9 µU/ml), as observed in several studies. [1][2][3][4][5][6][7][8][9][10] There was no difference in sex distribution in our patient population, similarly to what has been described in other studies. 12,13,21 The fact that only eight (4.7%) of 169 patients were following a treatment suggests that most of them had an isolated elevation of TSH levels hyperthyrotropinemia; corroborating the results found by several authors who studied DS patients.…”

Section: Discussionsupporting

confidence: 91%

“…This enzyme is believed to cause excessive production of hydrogen peroxide and to be involved in high levels of anti-TPO, since peroxidase is the substrate for peroxidase iodine. 6 However, the studies conducted by…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of thyroid dysfunction in DS is higher than in the general population, ranging from ORIGINAL ARTICLE 20 to 66%, depending on the study design, sample size, geographical region, age group and on whether cases of hypothyroidism and/or hyperthyroidism were analyzed. [1][2][3][4][5][6][7][8][9][10] These studies conclude that, due to such high prevalence, it is necessary to assess the thyroid function in the followup of DS patients.…”

Section: Introductionmentioning

confidence: 89%

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Avaliação etiológica da hipertirotropinemia em crianças com síndrome de Down

Dias¹,

Nunes²,

Araújo³

et al. 2005

J. Pediatr. (Rio J.)

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Objective: To study the prevalence of increased TSH level and its probable cause in children with Down s syndrome treated at Policlínica Antônio Cândido. Methods:The data were colleted using medical records of 169 patients. Of these, 46 patients, whose TSH increased at some time during their follow-up, were re-evaluated. In these patients, TSH, free T4, total T4 and thyroid peroxidase autoantibody (anti-TPO) levels were measured. Thyroid ultrasound, iodine-131 scintigraphy, and a perchlorate discharge test were performed.Results: In 169 children, 86 (50.8%) of whom were male, aged between 1-16 years (median 4 years), 67 (39.6%) presented increased TSH levels. Out of these 67 patients, 46 were prospectively studied. In 31 (67.4%) of them serum TSH returned to normal levels; in 11, TSH remained between 5 and 10 µU/ml, three (6.5%) had a TSH level over 10 µU/ml and one (2.2%) had hyperthyroidism. The diagnoses in 34 patients who were fully studied were: goiter in five (14.7%); Hashimoto s thyroiditis in four (5.9%); hypoplasia in three (8.8%) and iodide organification defect in one (2.9%). The increased TSH levels had a statistically positive relationship with anti-TPO (p = 0.02), but not with gender, abnormal ultrasound or scintigraphy findings. TSH levels did not have any relationship with persistent hyperthyrotropinemia. Conclusions:In patients with Down s syndrome, slightly elevated and transient TSH levels are frequently detected. Positive anti-TPO antibody test is a key factor in the follow-up of these patients because of its potential risk of progression to manifest thyroid disease.J Pediatr (Rio J). 2005;81(1):79-84: Down s syndrome, hyperthyrotropinemia, autoimmune thyroid disease, thyrotropin, hyperthyroidism.

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

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Avaliação etiológica da hipertirotropinemia em crianças com síndrome de Down

Dias¹,

Nunes²,

Araújo³

et al. 2005

J. Pediatr. (Rio J.)

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“…Os portadores da SD podem apresentar um aumento da freqüência de patologias auto-imunes e dentre estas estão: doença celíaca; hipotireiodismo por tireoidite de Hashimoto; diabetes melito; disfunção adrenal; anemia perniciosa; e hepatite crônica ativa (BAXTER et al, 1975;LIVO & GREEN, 1977;RUCH et al, 1985;BETTERLE et al, 1987;KENNEDY et al, 1992;CASTRO et al, 1993;GEORGE et al, 1996). Tendo sido caracterizada a prevalência do hipotireoidismo subclínico entre 28% e 64% em pacientes com SD (BAXTER et al, 1975;FORT et al, 1981;KENNEDY et al, 1992).…”

Section: 5-aspectos Específicos Na Conduta Da Síndrome De Downunclassified

“…Tendo sido caracterizada a prevalência do hipotireoidismo subclínico entre 28% e 64% em pacientes com SD (BAXTER et al, 1975;FORT et al, 1981;KENNEDY et al, 1992).…”

Section: 5-aspectos Específicos Na Conduta Da Síndrome De Downunclassified

Curvas padrão pôndero-estatural de portadores de Síndrome de Down procedentes da região urbana da cidade de São Paulo

Mustacchi¹

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Type 1 diabetes mellitus and Down's syndrome: prevalence, management and diabetic complications

1998

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Type 1 insulin‐dependent diabetes mellitus (Type 1 DM) is thought to be more prevalent in individuals with Down's syndrome. To ascertain the local prevalence of Type 1 DM in patients with Down's syndrome in a geographically defined area, the four diabetes clinics in Lothian were surveyed and 13 patients with Down's syndrome and Type 1 DM were identified. Using data from previous epidemiological surveys which determined the prevalence of Down's syndrome in the general population, the prevalence rate of Type 1 DM in patients with Down's syndrome was calculated to be between 1.4 and 10.6 %, a prevalence considerably higher than in the general population. Although 7 (54 %) of the Down's syndrome patients were treated with once daily administration of insulin, the mean HbA1c value of the group was similar to that observed in a control group of 39 age‐, sex‐ and duration‐matched Type 1 patients, all of whom were taking two or more injections of insulin daily. Glycaemic control was therefore of similar quality to matched Type 1 patients without Down's syndrome, despite the frequent use of simple insulin regimens, which may relate to the more stable lifestyle of these patients. © 1998 John Wiley & Sons, Ltd.

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Down's syndrome and the thyroid

Cited by 45 publications

References 63 publications

Avaliação etiológica da hipertirotropinemia em crianças com síndrome de Down

Avaliação etiológica da hipertirotropinemia em crianças com síndrome de Down

Curvas padrão pôndero-estatural de portadores de Síndrome de Down procedentes da região urbana da cidade de São Paulo

Type 1 diabetes mellitus and Down's syndrome: prevalence, management and diabetic complications

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