Down's syndrome screening: population statistic dependency of screening performance

Reynolds, Tim; Vranken, G.; Nueten, J. Van; Aldis, Jonathan

doi:10.1515/cclm.2008.099

Cited by 1 publication

(2 citation statements)

References 16 publications

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“…The characteristics of the studies are presented in Table 1 . A total of 18 articles 10 16 17 18 19 20 23 24 25 26 27 28 29 30 31 32 33 34 with 183,998 samples were included in this meta-analysis. The sample sizes of these studies ranged from 221 to 37,362, and the average number of samples per study was 10,222.…”

Section: Resultsmentioning

confidence: 99%

“…These voluntary screening tests which are used to evaluate the risk of DS consist of measuring combinations of biomarkers in maternal serum, including alpha fetoprotein (AFP), total human chorionic gonadotropin (hCG), free beta subunit of hCG (β-hCG), unconjugated estriol (uE3), pregnancy-associated plasma protein A (PAPP-A), proform of eosinophil major basic protein (ProMBP), inhibin-A, and placental growth factor (PGF). Studies of DS-affected pregnancies have demonstrated that serum screening tests exhibit sensitivities of 70–85% and specificities of 90–96% 16 17 18 . In recent years, ultrasonographic nuchal translucency (NT) measurements during the first trimester of gestation have been used in combination with serum screening tests; the integrated screening tests yield sensitivities of 90–95% with acceptable false-positive (FP) rates 19 20 .…”

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confidence: 99%

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Two kinds of common prenatal screening tests for Down’s syndrome: a systematic review and meta-analysis

Yao

Liao

Han

et al. 2016

Sci Rep

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As the chromosomal examination of foetal cells for the prenatal diagnosis of Down’s syndrome (DS) carries a risk of inducing miscarriage, serum screening tests are commonly used before invasive procedures. In this study, a total of 374 records from PubMed, EMBASE, and the ISI Science Citation Index databases were reviewed. As a result of duplication, insufficient data, and inappropriate article types, 18 independent articles containing 183,998 samples were used in the final systematic review and meta-analysis of the diagnostic performance of the serum triple screening test (STS) and the integrated screening test (INS). Data extracted from the selected studies were statistically analysed, and the presence of heterogeneity and publication bias was assessed using specific software. The overall sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and the area under the curve for the STS were 0.77 (95% confidence interval = 0.73–0.81), 0.94 (0.94–0.94), 9.78 (6.87–13.93), 0.26 (0.22–0.31), 44.72 (30.77–65.01), and 0.9064, respectively. For the INS, these values were 0.93 (0.90–0.95), 0.93 (0.93–0.93), 22.38 (12.47–40.14), 0.08 (0.05–0.11), 289.81 (169.08–496.76), and 0.9781, respectively. These results indicate that the INS exhibits better diagnostic value for DS. However, further research is needed to identify other biomarkers to improve prenatal screening tests.

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