Down's syndrome: Variation of leukemia occurrence in institutionalized populations

Childhood Cancer and Congenital Defects A Study of U.S. Death Certificates During the Period 1960–1966

“…Studies of case series have revealed that the distribution by cell type differs little from normal [28,29]. Leukemia with Down's syndrome was specified as myelogenous in 13.7% of the cases in our study, as compared with 10.5 % in the general population.…”

Causes of infertility in men with Down syndrome

“…Furthermore, there are only three cases, which means that we could probably not extract safe conclusions, applicable to most of the cases. Undescendent testis (cryptorchidism) is more prevalent amongst Down syndrome men (4% versus 0.23-1.58%) (Matsaniotis et al, 1967;Jackson et al, 1968;Li & Fraumeni, 1972).…”

The implications of S‐phase exchanges for the mechanisms of radiosensitivity in trisomy 21

“…Radiosensitivity of Down syndrome (DS) patients has been demonstrated on cultured lymphocytes in vitro [Countryman et al, 1977;Sasaki and Tonomura, 19691. It is also well known that DS individuals have an enhanced tendency for leukemia [Holland et al, 1962;Jackson et al, 1968;Krivit and Good, 1957;Miller, 19661. It has also been suggested that the increased chromosome abnormalities that are induced by X-rays in DS cells and the increased risk for leukemia could represent a defect in the system by which genetic damage is repaired [Countryman et al, 19771. This hypothesis was tested by comparing the frequencies of symmetrical and asymmetrical chromosome exchanges occurring in lymphocytes of normal and DS individuals after in vitro irradiation.…”