2019
DOI: 10.1111/pim.12624
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Down‐selecting circumsporozoite protein‐based malaria vaccine: A comparison of malaria sporozoite challenge model

Abstract: Summary Plasmodium falciparum circumsporozoite protein (PfCSP) is the main target antigen in development of pre‐erythrocytic malaria vaccines. To evaluate PfCSP vaccines in animal models, challenge by intravenous sporozoite injection is preferentially used. However, in clinical trials, vaccinated human volunteers are exposed to the bites of malaria‐infected mosquitoes. In this study, we down‐selected Escherichia coli‐produced full‐length PfCSP (PfCSP‐F) and its three truncated PfCSPs based on their abilities t… Show more

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Cited by 7 publications
(2 citation statements)
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“…Since it was first reported in 1995 (14), no further attempts were made to improve the design of RTS,S. Secondgeneration CSP vaccines are under development, including immunogens like the Walter Reed Army Institute of Research's nearly full-length CSP (FL-CSP) (15)(16)(17), hepatitis B particles with higher CSP epitope density than RTS,S (18), epitope broadened vaccines (19,20), or vaccines based on novel viral capsids or designed de novo (21)(22)(23)(24)(25)(26). All of these reports generally agree that the major poly-NPNA repeat is the most important target of protective Abs and one report suggested that a higher repeat copy number could improve Ab-mediated complement fixation (27).…”
mentioning
confidence: 99%
“…Since it was first reported in 1995 (14), no further attempts were made to improve the design of RTS,S. Secondgeneration CSP vaccines are under development, including immunogens like the Walter Reed Army Institute of Research's nearly full-length CSP (FL-CSP) (15)(16)(17), hepatitis B particles with higher CSP epitope density than RTS,S (18), epitope broadened vaccines (19,20), or vaccines based on novel viral capsids or designed de novo (21)(22)(23)(24)(25)(26). All of these reports generally agree that the major poly-NPNA repeat is the most important target of protective Abs and one report suggested that a higher repeat copy number could improve Ab-mediated complement fixation (27).…”
mentioning
confidence: 99%
“…9 A prime example is the emergence of partial artemisinin resistance, which has significantly threatened global malaria control efforts in the past decade. 10 While new studies explore the development of malarial vaccines, 11,12 there remains a pressing need to investigate natural sources for the discovery of more effective antimalarial lead molecules with minimal side effects.…”
Section: Introductionmentioning
confidence: 99%