Down syndrome and congenital heart disease : why the regional difference as observed in the Libyan experience?

Elmagrpy, Z.; Rayani, Amnna; Shah, Asadullah; Habas, Elmukhtar; Aburawi, E.H.

doi:10.5830/cvja-2010-072

Cited by 45 publications

(54 citation statements)

References 18 publications

(24 reference statements)

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“…The present study found among 40 CHD patients, 65% had isolated cardiac defect, which is similar to the study in libya, 7 however it is different as compared to 80% in Guatemala, 8 74% in Mexico, 3 78% in Turkey. 11 VSD was the most common isolated defect and was found in 9 of the 40 patients (22.5%), which was followed by AVSD (15%) then ASD (10%) and PDA (10%).…”

Section: Original Article |supporting

confidence: 88%

Down Syndrome and Congenital Heart Disease: Single centre, Prospective Study

Shrestha

2013

Nep J Med Sci

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Section: Original Article |supporting

confidence: 88%

Down Syndrome and Congenital Heart Disease: Single centre, Prospective Study

Shrestha

2013

Nep J Med Sci

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“…However,regional proximity alone cannot explain all the differences, as studies in African countries that also have regional proximity with Europe, such as Libya, have exhibited results that globally encompassed the spectrum of CHD in DS seen in Europe but with quite different rates in the different CHDs 21. As illustrated by the differences in reported rates of the different CHDs inDS between countries in close proximity, such as the USA and Mexico or other Latin American countries,3,4,8,11 it appears that regional proximity may have a greater effect in cases of geographical areas with long-standing populations, as in the Mediterranean area.…”

Section: Discussionmentioning

confidence: 99%

Congenital heart disease and Down syndrome: various aspects of a confirmed association

Benhaourech

Drighil

Hammiri

2016

CVJA

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SummaryBackgroundCongenital heart disease (CHD) is frequently described in patients with Down syndrome (DS) and is the main cause of death in this population during the first two years of life. The spectrum of CHD patterns in DS varies widely worldwide; this variation could be due to sociodemographic, genetic and geographic factors.MethodsA six-year retrospective, descriptive study was carried out from December 2008 to October 2014, based on the Paediatric Unit CHD registry of Ibn Rochd University Hospital. Clinical, echocardiographic and outcomes data were collected and sorted according to confirmation of the syndrome.ResultsAmong 2 156 patients with CHD, 128 were identified with Down syndrome. The genders were equally represented (gender ratio 1) and the median age at diagnosis was 9.5 months (2 days to 16 years). The median age of mothers at delivery was 39 years (16–47). Of the 186 CHD lesions reported, the most common was atrioventricular septal defect (AVSD, 29%), followed by ventricular septal defect (VSD,21.5%) and atrial septal defect (ASD, 19.9%). The most common associations of CHD were AVSD + ASD (10%) and VSD + ASD (7.8%). Surgery was the most common modality of treatment (54.3%). The overall mortality rate was 14.1%.ConclusionOur study confirmed that the profile and type of CHD in DS in the Moroccan setting exhibited slight differences in the distribution of these CHDs compared with European neighbours and other Western countries. Further studies are needed to determine which variables have an impact on these differences.

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“…3,[5][6][7][8][9][10][11][12][13][14][15][16][17] The types of heart defect may vary according to geographic region. In this study, the most common type was atrial septal defect, which was similar to the findings from other Table 1.…”

Section: Discussionmentioning

confidence: 99%

Down syndrome: Prevalence and distribution of congenital heart disease in Brazil

et al. 2015

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CONTEXT AND OBJECTIVE: Down syndrome is the most common genetic disorder, affecting 1/700 live births. Among the clinical findings, one constant concern is the high prevalence of congenital heart disease. The objective of this study was to determine the prevalence and profile of congenital heart disease among patients attended at a Down syndrome outpatient clinic in southern Brazil between 2005 and 2013. DESIGN AND SETTING: Cross-sectional study conducted in a referral center. METHODS: Data were retrospectively gathered from the medical files of 1,207 patients with Down syndrome, among whom 604 (50.0%) had been diagnosed with congenital heart disease. These data were subjected to descriptive analysis using the Statistica software. RESULTS: Among the 604 patients with congenital heart disease, 338 (55.8%) were male and 269 (44.5%) were female. The most common heart diseases were atrial septal defect in 254 patients (42.1%); total atrioventricular septal defect in 91 (15.1%); atrial septal defect and ventricular septal defect in 88 (14.6%); ventricular septal defect in 77 (12.7%); patent ductus arteriosus in 40 (6.6%); patent foramen ovale in 34 (5.6%) patients; tetralogy of Fallot in 12 (2%); and other diseases in 8 (1.3%). Pulmonary hypertension was present in 57 (9.4%). Out of the total, 150 patients (24.8%) underwent cardiac surgery. CONCLUSION: The high prevalence of congenital heart disease among the patients at the Down syndrome outpatient clinic (50%) was similar to findings from other studies and justifies investigation during the neonatal period, so as to decrease mortality and morbidity. RESUMO

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Down syndrome and congenital heart disease : why the regional difference as observed in the Libyan experience?

Cited by 45 publications

References 18 publications

Down Syndrome and Congenital Heart Disease: Single centre, Prospective Study

Down Syndrome and Congenital Heart Disease: Single centre, Prospective Study

Congenital heart disease and Down syndrome: various aspects of a confirmed association

Down syndrome: Prevalence and distribution of congenital heart disease in Brazil

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