Down Syndrome and Postoperative Complications in Children Undergoing Intestinal Operations

Cairo, Sarah B.; Zeinali, Lida; Berkelhamer, Sara; Harmon, Carroll M.; Rao, Sri O.; Rothstein, David H.

doi:10.1016/j.jpedsurg.2018.11.013

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…Of these 42 articles, 13 used a casecontrol design, 27 reported on cohorts, and three were matched case-control studies. From the case-control studies, studies used inpatient admission data of patients without DS (Cairo et al, 2019;Jensen et al, 2015;Kristensen, Hjuler, Ravn, Simões, & Stensballe, 2012;Pérez-Padilla et al, 2010;Ramphul, Mejias, & Joynauth, 2019;Sánchez-Luna et al, 2017;Zachariah, Ruttenber, & Simões, 2012;Zhang, Guo, Langley, & Bai, 2013) healthy controls (Boylan et al, 2016;Megged & Schlesinger, 2010;Uppal et al, 2015), and sibling controls (Bloemers et al, 2007;Nisihara, Utiyama, Oliveira, & Messias-Reason, 2010). Of the 42 articles,…”

Section: Original Literature Reviewmentioning

confidence: 99%

“…Eleven articles describe specific cohorts with DS and an additional diagnosis which may give insight into risk factors. Specifically, pneumonia and respiratory infections were described in those: undergoing treatment for DS-AML (Hassler et al, 2016;Kudo et al, 2007;Lehrnbecher et al, 2004), with congenital heart disease (Bush et al, 2018;Layangool et al, 2014;Thompson, McElhinney, Jue, & Hodge, 1999), and those who had undergone orthopedic procedures (Boylan et al, 2016;Lerman, Emans, Hall, & Karlin, 2003;Siemionow, Hansdorfer, Janusz, & Mardjetko, 2017), intestinal surgeries (Buchin, Levy, & Schullinger, 1986;Cairo et al, 2019), or airway procedures (Cockerill, Frisch, Rein, & Orvidas, 2016;Pravit, 2014). Airway anomalies, GERD, and pulmonary hypertension were associated with recurrent pneumonia (Bush et al, 2018;Pravit, 2014;Thompson et al, 1999).…”

Section: Original Literature Reviewmentioning

confidence: 99%

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Pneumonia and respiratory infections in Down syndrome: A scoping review of the literature

Santoro

Chicoine

Jasien

et al. 2020

American J of Med Genetics Pt A

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Pneumonia and respiratory infections impact infants and children with Down syndrome; pneumonia is a leading cause of mortality in adults with Down syndrome. We aimed to review the literature to evaluate gaps and address key questions. A series of key questions were formulated a priori to inform the search strategy and review process; addressed prevalence, severity, etiology, risk factors, preventive methods, screening, and financial costs, potential benefits or harms of screening. Using the National Library of Medicine database, PubMed, detailed literature searches on pneumonia and respiratory infections in Down syndrome were performed. Previously identified review articles were also assessed. The quality of available evidence was then evaluated and knowledge gaps were identified. Forty‐two relevant original articles were identified which addressed at least one key question. Study details including research design, internal validity, external validity, and relevant results are presented. Pneumonia and respiratory infections are more prevalent and more severe in individuals with Down syndrome compared to healthy controls through literature review, yet there are gaps in the literature regarding the etiology of pneumonia, the infectious organism, risk factors for infection, and to guide options for prevention and screening. There is urgent need for additional research studies in Down syndrome, especially in the time of the current COVID‐19 pandemic.

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Section: Original Literature Reviewmentioning

confidence: 99%

Section: Original Literature Reviewmentioning

confidence: 99%

Pneumonia and respiratory infections in Down syndrome: A scoping review of the literature

Santoro

Chicoine

Jasien

et al. 2020

American J of Med Genetics Pt A

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“… 71 In one study mortality and major complication rates were lower for patients with Down syndrome. 65 Similarly, further studies also focusing on Down syndrome found mortality and medical complications to be significantly lower for patients with Down syndrome with no significant differences in terms of surgical complications, 68 and lower odds of in-hospital death for patients with Down syndrome when controlling for other factors such as risk category and premature birth. 61 In four studies no differences in mortality were reported, 62–64 66 and in one study children with intellectual disability had a higher risk of 30-day mortality compared with children with no intellectual disability.…”

Section: Resultsmentioning

confidence: 98%

“…15 Thirteen further articles reported on postoperative outcomes. [59][60][61][62][63][64][65][66][67][68][69][70][71] The majority of articles included data relating to Down syndrome, 59-61 63-65 68 69 followed by intellectual disability, 62 67 70 developmental delay 66 and autism spectrum disorder. 71 Increased rates of complications 60 62 63 66 69 70 were reported in a number of studies.…”

Section: Postoperative Outcomesmentioning

confidence: 99%

Exploring patient safety outcomes for people with learning disabilities in acute hospital settings: a scoping review

et al. 2021

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ObjectivesTo produce a narrative synthesis of published academic and grey literature focusing on patient safety outcomes for people with learning disabilities in an acute hospital setting.DesignScoping review with narrative synthesis.MethodsThe review followed the six stages of the Arksey and O’Malley framework. We searched four research databases from January 2000 to March 2021, in addition to handsearching and backwards searching using terms relating to our eligibility criteria—patient safety and adverse events, learning disability and hospital setting. Following stakeholder input, we searched grey literature databases and specific websites of known organisations until March 2020. Potentially relevant articles and grey literature materials were screened against the eligibility criteria. Findings were extracted and collated in data charting forms.Results45 academic articles and 33 grey literature materials were included, and we organised the findings around six concepts: (1) adverse events, patient safety and quality of care; (2) maternal and infant outcomes; (3) postoperative outcomes; (4) role of family and carers; (5) understanding needs in hospital and (6) supporting initiatives, recommendations and good practice examples. The findings suggest inequalities and inequities for a range of specific patient safety outcomes including adverse events, quality of care, maternal and infant outcomes and postoperative outcomes, in addition to potential protective factors, such as the roles of family and carers and the extent to which health professionals are able to understand the needs of people with learning disabilities.ConclusionPeople with learning disabilities appear to experience poorer patient safety outcomes in hospital. The involvement of family and carers, and understanding and effectively meeting the needs of people with learning disabilities may play a protective role. Promising interventions and examples of good practice exist, however many of these have not been implemented consistently and warrant further robust evaluation.

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“…One study showed that children with Down syndrome have a higher mortality rate for bacterial sepsis . However, there is no general incidence rate known, and within the context of gastrointestinal surgery there appears to be less sepsis in Down syndrome . Appendicitis seems to be less common in Down syndrome .…”

Section: Introductionmentioning

confidence: 99%

Clinical implications of immune‐mediated diseases in children with Down syndrome

Verstegen

Chang

Kusters

2019

Pediatric Allergy Immunology

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Children with Down syndrome have changes in their innate and adaptive immunity, which contribute to increased rates of infections, autoimmune diseases, and haematological malignancies. While improved care for congenital heart disease has decreased mortality and morbidity, complications related to immune‐mediated diseases continue to limit the life expectancy in Down syndrome. Infectious diseases are common and have a significant effect on development, behaviour and quality of life. Infection frequency and severity are influenced by various anatomical and physiological alterations in addition to immunological changes in Down syndrome. Thus, prevention of respiratory tract infections requires a multifactorial approach. This could include additional active and/or passive immunizations, prophylactic antibiotics, immunoglobulin replacement and ear, nose and throat surgical interventions. Autoimmune conditions like coeliac disease, type I diabetes mellitus and thyroid disease are classically mentioned in the context of Down syndrome. However, autoinflammatory conditions are more prevalent as well. Screening for autoimmune diseases is required and immunosuppression has to be used with caution. Future studies should address optimal screening programmes for immune‐mediated diseases in individuals with Down syndrome, as well as the effect of immune modulation, to further decrease morbidity and mortality, and improve the quality of life of individuals with Down syndrome.

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Down Syndrome and Postoperative Complications in Children Undergoing Intestinal Operations

Cited by 7 publications

References 41 publications

Pneumonia and respiratory infections in Down syndrome: A scoping review of the literature

Pneumonia and respiratory infections in Down syndrome: A scoping review of the literature

Exploring patient safety outcomes for people with learning disabilities in acute hospital settings: a scoping review

Clinical implications of immune‐mediated diseases in children with Down syndrome

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