Down syndrome: systematic review of the prevalence and nature of presentation of unipolar depression

Walton, Catherine; Kerr, Mike

doi:10.1108/amhid-11-2014-0037

Cited by 14 publications

(7 citation statements)

References 26 publications

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“…The co‐occurrence of dementia or Alzheimer's disease was three times more likely to be reported by adults with DS than adults with ID (without DS). Although dementia/Alzheimer's disease is a worrisome condition for adults with DS, depression may be the most common psychiatric disorder reported in persons with DS (Walton & Kerr, ). We found an intriguing finding related to age and depression in our sample of adults with DS.…”

Section: Discussionmentioning

confidence: 99%

Psychiatric Conditions Prevalent Among Adults With Down Syndrome

Tassé

Macho

Havercamp

et al. 2016

Policy Practice Intel Disabi

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The authors assessed available prevalence information regarding neuropsychiatric conditions among adults with Down syndrome (DS) and compared these findings among adults with other intellectual disability (non-DS). The study entailed a survey of 291 adults with DS living in Ohio (USA). Twenty-three percent of adults with DS reported having a co-occurring psychiatric disorder, a smaller than the reported occurrence of such conditions in the general adult intellectual disability population. Depression, anxiety disorders, and dementia or Alzheimer's disease were the most frequently reported neuropsychiatric disorders by adults with DS. The likelihood of experiencing a psychiatric disorder increased with age but did not vary by sex among adults with DS. Lower rates of problem behavior were reported in adults with DS compared to adults with intellectual disability (non-DS). The authors' findings indicate that adults with DS may present different rates and types of co-occurring psychiatric disorders than the larger population of adults with other intellectual disability. These findings warrant additional research and could provide critical information for planning and intervention.

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Section: Discussionmentioning

confidence: 99%

Psychiatric Conditions Prevalent Among Adults With Down Syndrome

Tassé

Macho

Havercamp

et al. 2016

Policy Practice Intel Disabi

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“…More common is accompanying physical disorder (DC-LD, 2001). Depression is relatively more common in Down Syndrome subjects than in comparison to the ID population in general; this on a background of mental ill health (all causes) being less common in Down syndrome (Walton and Kerr, 2015).…”

Section: Depressionmentioning

confidence: 86%

Psychiatry and intellectual disabilities: navigating complexity and context

Jones

Jeenkeri

Cutajar

2017

JMHTEP

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Purpose The paper is a review, for the general adult mental health practitioner, of the issues to consider when managing a mental health presentation of a person with intellectual disability (PWID). The paper aims to discuss these issues. Design/methodology/approach A neurodevelopmental model is outlined to assist practitioners in unravelling the wide range of potential factors relevant to intellectual disabilities (IDs). This includes an emphasis on complexity and interdisciplinary formulation within an individual’s context, and implications of the current policy changes. Findings In practice, managing the mental health of PWID can be challenging within usual mainstream services; there is more to consider than is usual for the general population. Originality/value The paper provides general mental health practitioners with a framework for a greater depth of understanding of the issues involved in the management of people with intellectual disability (ID). This includes discussion of the current policy context in ID, and some of its limitations.

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“…The observation of an individual for changes in behaviour is an essential requirement for the diagnosis of depression. There is a difference between behavioural changes (how an individual perceives, and interacts with their environment plus eating and sleeping) and challenging behaviour (Walton and Kerr, 2015). In the general ID population, Meins (1995) concluded that new behaviour problems were observed to start equally in both mild-moderate ID and severe ID when the groups were compared.…”

Section: Appendix 1 Rationale For the Exclusion Of Challenging Behaviourmentioning

confidence: 99%

Prader Willi syndrome: systematic review of the prevalence and nature of presentation of unipolar depression

Walton

Kerr

2016

Advances in Mental Health and Intellectual Disabilities

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Purpose – The purpose of this paper is to assess the prevalence and nature of presentation of unipolar depression in individuals with Prader-Willi syndrome (PWS). Design/methodology/approach – The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) (2009) checklist for systematic reviews was followed where possible. Findings – Seven studies were included in the qualitative synthesis from a total of 261 records identified. The quality of the studies was then assessed: scores for each study design ranged from between 3 and 6 of a possible score total of 6. The frequency of depression ranged between studies from 4 to 22 per cent. four studies showed over 50 per cent of patients appeared to suffer from psychotic symptoms. Low mood, anhedonia and irritability were described as features of depression, although no fixed pattern of psychopathology arose from across the studies (excluding psychosis). This review has provided evidence to suggest that depression is a frequent occurrence in the PWS population. One study found that the incidence of depression differed between the genetic subtypes, raising questions regarding the relationship between genotype and behavioural phenotypes. A high proportion of individuals with depression suffered from psychotic symptoms. Research limitations/implications – The small number of heterogeneous studies included in this study precluded meta-analysis of the results. This highlights the need for further original research in this field. Practical implications – An increased awareness of the frequency of depressive symptoms within the PWS population will aid in the timely diagnosis and management of the disorder which will reduce psychiatric morbidity. The noted high proportion of psychotic symptoms associated with depression should raise the index of suspicion with clinicians and aid appropriate management decisions. Originality/value – This review has provided preliminary evidence for the nature of presentation of unipolar depression in PWS. It has highlighted the possibility of an increased propensity towards depression with psychotic symptoms. There is some suggestion of a differing presentation and course of unipolar depression between the common genetic subtypes of PWS which warrants further investigation.

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Down syndrome: systematic review of the prevalence and nature of presentation of unipolar depression

Cited by 14 publications

References 26 publications

Psychiatric Conditions Prevalent Among Adults With Down Syndrome

Psychiatric Conditions Prevalent Among Adults With Down Syndrome

Psychiatry and intellectual disabilities: navigating complexity and context

Prader Willi syndrome: systematic review of the prevalence and nature of presentation of unipolar depression

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