Downregulated Expression of linc-ROR in Gastric Cancer and Its Potential Diagnostic and Prognosis Value

Abstract

Background. Gastric cancer (GC) is one of the global mortality diseases and has a poor prognosis due to the lack of ideal tumor biomarkers. Numerous studies have shown that long noncoding RNAs (lncRNAs) can affect the occurrence and development of cancer through a variety of signaling pathways. The abnormal expression and specificity of lncRNAs in tumors make them potential biomarkers of cancers. Nevertheless, the diagnostic roles of lncRNAs in GC have been poorly understood. So this study focuses on the clinical diagnostic value of lncRNAs in GC. Materials and Methods. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to investigate the expression of the linc-ROR (long intergenic noncoding RNA, regulator of reprogramming) in 105 paired GC tissues and adjacent normal tissues. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were established to assess the diagnostic value of linc-ROR. The relationship between expression of linc-ROR and clinicopathological factors of patients with GC was further explored. Kaplan-Meier analysis was performed to evaluate the prognostic value of linc-ROR expression. Results. The linc-ROR expression level was significantly decreased in GC tissues compared with its adjacent nontumor tissues ( n = 105 , P < 0.001 ). We also discovered that linc-ROR was evidently downregulated in 68.6% (72/105) of GC tissues. The AUC’s value of linc-ROR was up to 0.6495, with sensitivity and specificity of 0.7524 and 0.5143, respectively. Intriguingly, the linc-ROR expression levels were obviously associated with tumor differentiation ( P = 0.004 ). Notably, the overall survival rate of GC patients with high expression of linc-ROR was significantly higher than those with low expression. Conclusion. Our data revealed that linc-ROR has clinical potential as a biomarker for the diagnosis of GC and assessment of its prognosis.

Down-regulation of LINC-ROR, HOXA-AS2 and MEG3 in gastric cancer

“…The obtained AUC value for LINC-ROR in the current study is comparable with Yu et al. study [ 18 ], yet the specificity of this marker in our study is far beyond their study [ 18 ]. However, the AUC value obtained for combination of two lncRNAs was not high enough.…”

“…have reported down-regulation of LINC-ROR in gastric cancer tissues compared with their nearby non-tumor tissues. Notably, expression of this lncRNA has been associated with tumor differentiation [ 18 ]. LINC-ROR expression has been previously assessed in a cohort of Iranian patients with diverse types of cancers revealing its up-regulation in esophageal, ovarian, and cervical cancers, while being down-regulated in breast, sarcoma, colon, and melanoma patients [ 19 ].…”

Helicobacter pylori Infection–Related Long Non-Coding RNA Signatures Predict the Prognostic Status for Gastric Cancer Patients

“…Wang et al indicated that the high expression of SCD1 might predict poor prognosis in gastric cancer patients, but the AUC value at 1-, 3-, and 5-year survival rates were 0.557, 0.569, and 0.595, respectively (26), were significantly lower than the results of our study. In addition, the AUC's value of another predictive biomaker (linc-ROR) was 0.6495 (27), which was also lower than ours. So, we proposed that our findings improved the prediction accuracy for the prognosis of gastric cancer patients.…”

Abnormally Expressed lncRNAs as Potential Biomarkers for Gastric Cancer Risk: A Diagnostic Meta-Bioinformatics Analysis

“…We assessed the quality of included studies using NOS and found that the quality of the enrolled studies was acceptable. Thirty-eight studies [ 9 , 12 , 14 , 21 – 27 , 29 – 31 , 33 , 34 , 36 , 38 – 40 , 42 , 46 – 50 , 52 – 55 , 57 , 62 , 63 , 65 , 66 ] were of high quality while the other 16 studies [ 28 , 32 , 35 , 37 , 41 , 43 , 47 , 51 , 56 , 58 – 61 , 64 , 67 ] were of moderate quality.…”