Downregulated regulatory T cell function is associated with increased peptic ulcer in Helicobacter pylori-infection

Bagheri, Nader; Shirzad, Hedayatollah; Elahi, Shokrollah; Azadegan‐Dehkordi, Fatemeh; Rahimian, Ghorbanali; Shafigh, Mohammedhadi; Rashidii, Reza; Sarafnejad, A; Rafieian-Kopaei, Mahmoud; Faridani, Rana; Tahmasbi, Kamran; Kheiri, Soleiman; Razavi, Alireza

doi:10.1016/j.micpath.2017.06.040

Cited by 54 publications

(38 citation statements)

References 42 publications

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“…Diminished IL‐35 levels in PU patients could suggest a disruption in Treg cell activity in these patients. In agreement with our findings, downregulated Treg cell activity has been associated with PU development in H. pylori ‐infected subjects …”

Section: Discussionsupporting

confidence: 93%

“…Some studies indicated that Th1 and Th17 cell‐related responses might be protective or pathogenic, whereas Th2 and T regulatory (Treg) cell‐linked responses exert anti‐inflammatory effects . Indeed, a downregulation of the Treg cell function was associated with PU development in H. pylori ‐infected patients …”

Section: Introductionmentioning

confidence: 99%

“…17,18 Indeed, a downregulation of the Treg cell function was associated with PU development in H. pylori-infected patients. 19 The Treg cells constitute about 5% to 10% of the peripheral CD4 + T cells and play a critical role in controlling of immune responses and preventing autoimmune reactions. 20 Treg cells can be divided into natural Treg (nTreg) and as induced (iTreg) subsets: the first ones differentiate in the thymus, while the latter originate from peripherally activated naïve CD4 + T cells.…”

Section: Introductionmentioning

confidence: 99%

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Diminished circulating concentration of interleukin‐35 in Helicobacter pylori‐infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism, bacterial virulence factor CagA, and gender of patients

et al. 2018

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diminished circulating concentration of interleukin‐35 in Helicobacter pylori‐infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism, bacterial virulence factor CagA, and gender of patients

et al. 2018

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“…171 In particular, it has been shown that downregulation of regulatory T-cell function is associated with the development of life threatening peptic ulcers in humans infected with H. pylori. 172 This result has been echoed in mice where IL-10 has been demonstrated to be essential for preventing H. pylori induced gastritis in Rag2 −/− mice. It has also been shown that downregulated inflammatory responses are associated with reduced gastritis in children.…”

Section: H Pylorimentioning

confidence: 96%

“…In this case, the appropriate immune response requires a balance to be reached consisting of an inflammatory response that is necessary for microbe control, and negative feedback to ensure the response is not overly harmful to the host . In particular, it has been shown that downregulation of regulatory T‐cell function is associated with the development of life threatening peptic ulcers in humans infected with H. pylori . This result has been echoed in mice where IL‐10 has been demonstrated to be essential for preventing H. pylori induced gastritis in Rag2 −/− mice.…”

Section: The Concept Of Balance In Other Diseasesmentioning

confidence: 99%

Dynamic balance of pro‐ and anti‐inflammatory signals controls disease and limits pathology

Cicchese

Evans

Hult

et al. 2018

Immunological Reviews

235

171

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Immune responses to pathogens are complex and not well understood in many diseases, and this is especially true for infections by persistent pathogens. One mechanism that allows for long-term control of infection while also preventing an over-zealous inflammatory response from causing extensive tissue damage is for the immune system to balance pro- and anti-inflammatory cells and signals. This balance is dynamic and the immune system responds to cues from both host and pathogen, maintaining a steady state across multiple scales through continuous feedback. Identifying the signals, cells, cytokines, and other immune response factors that mediate this balance over time has been difficult using traditional research strategies. Computational modeling studies based on data from traditional systems can identify how this balance contributes to immunity. Here we provide evidence from both experimental and mathematical/computational studies to support the concept of a dynamic balance operating during persistent and other infection scenarios. We focus mainly on tuberculosis, currently the leading cause of death due to infectious disease in the world, and also provide evidence for other infections. A better understanding of the dynamically balanced immune response can help shape treatment strategies that utilize both drugs and host-directed therapies.

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Increased infiltration of CD4⁺IL‐17A⁺FOXP3⁺ T cells in Helicobacter pylori‐induced gastritis

Guo,

Chen,

Huang

et al. 2024

Eur J Immunol

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Helicobacter pylori is one of the main predisposing factors for gastric cancer, causing chronic inflammation and proper glands atrophy in the gastric mucosa. Although H. pylori‐induced inflammation is a key inducer of precancerous lesions in the gastric mucosa, it remains unclear which precise immune cell subsets are responsible for the progression of H. pylori‐induced gastritis. Here, we observed an abundance of CD4+IL‐17A+FOXP3+ T cells exhibiting a Th17‐like phenotype within the microenvironment of H. pylori‐induced gastritis. Mechanistically, H. pylori upregulated the expression of IL‐6 in Dendritic cells and macrophages, by activating NF‐κB signaling through the virulence factor CagA and thus, induced IL‐17A expression in FOXP3+ T cells. Moreover, CD4+IL‐17A+FOXP3+ T cells were positively associated with advanced precancerous lesions. Therefore, these findings offer essential insights into how FOXP3+ T cells sense inflammatory signals from the environment, such as IL‐6, during H. pylori infections, thereby guiding the effector immune response and aggravating the gastritis.

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Downregulated regulatory T cell function is associated with increased peptic ulcer in Helicobacter pylori-infection

Cited by 54 publications

References 42 publications

Diminished circulating concentration of interleukin‐35 in Helicobacter pylori‐infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism, bacterial virulence factor CagA, and gender of patients

Diminished circulating concentration of interleukin‐35 in Helicobacter pylori‐infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism, bacterial virulence factor CagA, and gender of patients

Dynamic balance of pro‐ and anti‐inflammatory signals controls disease and limits pathology

Increased infiltration of CD4⁺IL‐17A⁺FOXP3⁺ T cells in Helicobacter pylori‐induced gastritis

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Downregulated regulatory T cell function is associated with increased peptic ulcer in Helicobacter pylori-infection

Cited by 54 publications

References 42 publications

Diminished circulating concentration of interleukin‐35 in Helicobacter pylori‐infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism, bacterial virulence factor CagA, and gender of patients

Diminished circulating concentration of interleukin‐35 in Helicobacter pylori‐infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism, bacterial virulence factor CagA, and gender of patients

Dynamic balance of pro‐ and anti‐inflammatory signals controls disease and limits pathology

Increased infiltration of CD4+IL‐17A+FOXP3+ T cells in Helicobacter pylori‐induced gastritis

Contact Info

Product

Resources

About

Increased infiltration of CD4⁺IL‐17A⁺FOXP3⁺ T cells in Helicobacter pylori‐induced gastritis